scholarly journals Effect of Hirulog-Like Peptide on Balloon Catheter Injury-Induced Neointimal Formation in Femoral Arteries of Minipigs and Relationship with Inflammatory Mediators

2010 ◽  
Vol 47 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Xiao-Feng Tang ◽  
Jian-Jun Liu ◽  
Yong-Jie Wu ◽  
Ke-Ming Chen ◽  
Yong Jin ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Balloon Catheter ◽  
Neointimal Formation ◽  
Femoral Arteries ◽  
Balloon Catheter Injury

Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture

2002 ◽  
Vol 283 (2) ◽  
pp. H760-H767 ◽  
Author(s):  
Ciro Indolfi ◽  
Daniele Torella ◽  
Carmela Coppola ◽  
Eugenio Stabile ◽  
Giovanni Esposito ◽  
...  
Keyword(s):  
Balloon Catheter ◽  
Balloon Dilation ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Proliferation Index ◽  
Neointimal Formation ◽  
Internal Elastic Lamina ◽  
Ki 67 ◽  
Injury Index ◽  
Great Relevance ◽  
Transluminal Coronary Angioplasty

The best animal angioplasty model is the porcine model, which is expensive and not available in all laboratories. The aim of this study was to describe a new rat model of angioplasty. An injury was induced with the use of a standard percutaneous transluminal coronary angioplasty (PTCA) 1.5-mm balloon catheter. The neointimal tissue, arterial dimensions, and the injury index were assessed following angioplasty. Ki-67 expression was detected to evaluate cell turnover after balloon angioplasty. In contrast with the standard Clowes model, a significant neointimal formation was detected only in the presence of ruptured internal elastic lamina (IEL). A positive correlation between the percentage of ruptured IEL and the amount of neointimal tissue was also demonstrated. The percentage of IEL fracture correlates with the proliferation index by anti-Ki-67 immunolabeling 7 and 14 days after the angioplasty. Significant arterial negative remodeling was observed following PTCA balloon dilation. In conclusion, our inexpensive animal model of restenosis after angioplasty may have great relevance toward a better understanding of the mechanisms and toward assessment of new therapeutical strategies for this phenomenon.

Balloon Catheter Injury and Vein Graft Morphology and Function

1996 ◽  
Vol 10 (5) ◽  
pp. 429-442 ◽  
Author(s):  
Mark G. Davies ◽  
Helge Dalen ◽  
Einar Svendsen ◽  
Per-Otto Hagen
Keyword(s):  
Vein Graft ◽  
Balloon Catheter ◽  
And Function ◽  
Graft Morphology ◽  
Balloon Catheter Injury

scholarly journals Early inhibition of myointimal proliferation by angiopeptin after balloon catheter injury in the rabbit

1994 ◽  
Vol 19 (6) ◽  
pp. 1084-1091 ◽  
Author(s):  
Marie L. Foegh ◽  
Satish Asotra ◽  
John V. Conte ◽  
Marcus Howell ◽  
Elliott Kagan ◽  
...  
Keyword(s):  
Balloon Catheter ◽  
Early Inhibition ◽  
Balloon Catheter Injury
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