Prognostic Factors in Anorexia nervosa

1988 ◽  
Vol 49 (3-4) ◽  
pp. 137-144 ◽  
Author(s):  
Klaus Engel
2009 ◽  
Vol 194 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Fotios C. Papadopoulos ◽  
Anders Ekbom ◽  
Lena Brandt ◽  
Lisa Ekselius

BackgroundAnorexia nervosa is a mental disorder with high mortality.AimsTo estimate standardised mortality ratios (SMRs) and to investigate potential prognostic factors.MethodSix thousand and nine women who had in-patient treatment for anorexia nervosa were followed-up retrospectively using Swedish registers.ResultsThe overall SMR for anorexia nervosa was 6.2 (95% CI 5.5– 7.0). Anorexia nervosa, psychoactive substance use and suicide had the highest SMR. The SMR was significantly increased for almost all natural and unnatural causes of death. The SMR 20 years or more after the first hospitalisation remained significantly high. Lower mortality was found during the last two decades. Younger age and longer hospital stay at first hospitalisation was associated with better outcome, and psychiatric and somatic comorbidity worsened the outcome.ConclusionsAnorexia nervosa is characterised by high lifetime mortality from both natural and unnatural causes. Assessment and treatment of psychiatric comorbidity, especially alcohol misuse, may be a pathway to better long-term outcome.


Author(s):  
Luca Errichiello ◽  
Davide Iodice ◽  
Dario Bruzzese ◽  
Marco Gherghi ◽  
Ignazio Senatore

1991 ◽  
Vol 158 (4) ◽  
pp. 495-502 ◽  
Author(s):  
R. H. Ratnasuriya ◽  
I. Eisler ◽  
G. I. Szmukler ◽  
G. F. M. Russell

Forty-one patients with anorexia nervosa, admitted to the Maudsley Hospital between 1959 and 1966, were followed up after a mean of 20 years. An assessment of general outcome (based on the Morgan-Russell scales) yielded three outcome categories: ‘good’ (n = 12), ‘intermediate’ (n = 13) and ‘poor’ (n = 15). Six patients (15%) had died from causes related to anorexia nervosa; at least 15% had developed bulimia nervosa. There was a general consistency between the follow-up at 20 years and that previously conducted five years after admission, although with a few individual patients there were serious prognostic errors at the earlier follow-up. A poorer outcome was associated with a later age of onset, a history of neurotic and personality disturbances, disturbed relationships in the family and a longer duration of illness.


1989 ◽  
Vol 575 (1 The Psychobio) ◽  
pp. 567-568 ◽  
Author(s):  
R. H. RATNASURIYA ◽  
I. EISLER ◽  
G. SZMUKLER ◽  
G. F. M. RUSSELL

2021 ◽  
Vol 12 ◽  
Author(s):  
Maurizio Speciani ◽  
Yoram Barak ◽  
Hanafi Damanhuri ◽  
Diana De Ronchi ◽  
Fabio Panariello ◽  
...  

Anorexia Nervosa (AN) is a severe eating disorder which typically develops in younger females. Many studies focus on this specific population, a majority of which will eventually partially or fully recover. A minority will become chronic despite extensive treatment. These patients are treatment-resistant and may not necessarily benefit from usual treatment. In this article we will reflect on possible mechanisms which may explain the maintenance of disease, and especially on the possible role of affective and anxiety disturbances. We will use, due to the lack of large-scale studies, data from risk and prognostic factors, treatment options and neurobiological correlates in chronic AN patients. Lastly, we will propose how these elements may advise further research and treatments.


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