Neuroimaging and the Pathophysiology and Treatment of Depression: Recent Advances and Future Needs

Author(s):  
Dara M. Cannon
2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.


Author(s):  
M. Piringer ◽  
C. S. B. Grimmond ◽  
S. M. Joffre ◽  
P. Mestayer ◽  
D. R. Middleton ◽  
...  

2004 ◽  
Vol 5 (3) ◽  
pp. 255-274 ◽  
Author(s):  
Jonathan W. Kanter ◽  
Glenn M. Callaghan ◽  
Sara J. Landes ◽  
Andrew M. Busch ◽  
Keri R. Brown

1968 ◽  
Vol 114 (509) ◽  
pp. 459-463 ◽  
Author(s):  
Raymond Levy∗

Electroconvulsive therapy (E.C.T.), first introduced in 1937, rapidly became accepted as playing an important part in the treatment of depression. Since its introduction, there have been few modifications of the technique that have stood the test of time. The most important has been the use of muscular relaxants to modify the convulsion. Most recent advances have been directed towards the development of reliable criteria for the selection of patients most likely to respond to treatment, but little attention has been paid to improvements in the method of treatment as such.


1991 ◽  
Vol 4 (1) ◽  
pp. 70-72
Author(s):  
John M. Zajecka ◽  
Jan Fawcett

The current design trends for today’s high voltage air-blast circuit breakers are described. The special advantages of using air as a switching medium are related to the requirements of the present and future needs of e.h.v. and u.h.v. supply networks. Some research currently being carried out throughout the world with relevance to gas-blast interrupters is mentioned.


2013 ◽  
Vol 299 ◽  
pp. 1-5 ◽  
Author(s):  
Paul C. Rogers ◽  
Cristina Eisenberg ◽  
Samuel B. St. Clair

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