Serum �-N-Acetylglucosaminidase Activity in Diabetic Patients during Conventional Therapy and during Treatment by Artificial Systems for Insulin Delivery

Author(s):  
D. Arena ◽  
A. Orlacchio ◽  
M. De Angelis ◽  
C. Maffei ◽  
P. Brunetti
Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 730-P
Author(s):  
JORDAN E. PINSKER ◽  
SUNIL DESHPANDE ◽  
MEI MEI CHURCH ◽  
MOLLY PIPER ◽  
CAMILLE C. ANDRE ◽  
...  

2018 ◽  
Vol 6 (6) ◽  
pp. 1480-1491 ◽  
Author(s):  
Mian Fu ◽  
Chenyu Zhang ◽  
Yuxuan Dai ◽  
Xue Li ◽  
Miaobo Pan ◽  
...  

Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve the health and quality of life of diabetic patients.


2020 ◽  
Author(s):  
Adeladlew Kassie Netere ◽  
Eyayaw Ashete ◽  
Eyob Alemayehu Gebreyohannes ◽  
Sewunet Admasu Belachew

Abstract Background: Insulin is an effective therapeutic agent in the management of diabetes but it is also sensitive to external environment. Consequently, diabetic patients’ adherence to insulin delivery recommendations is critical to its effectiveness. Lack of knowledge, skill, and irrational practices on appropriate insulin delivery techniques can result in therapeutic failure and increased costs of therapy. The aim of this study was to evaluate the knowledge, skills, and practices of insulin storage and injection technique of patients. Methods : An interview-based cross-sectional study was conducted in conveniently selected participants in Northwest Ethiopian primary hospitals from March 1 to May 30, 2019. Knowledge levels were assessed with right or wrong responses and practice was measured by administering a 4-point Likert scale structured questionnaire through face-to-face interviews. Finally, a five-point observational (demonstration) techniques checklist assessed patients’ skills. Results: Among 194 patients approached, 166 participants completed the survey with a response rate of 85.6 %. From these participants, 54.8% were males and the mean age was 38.46±13.8 years . The overall patients’ median knowledge and practice levels on insulin storage and handling techniques were moderately adequate (64.3%) and fair (55.4%), respectively. In patients’ skill assessments, 94.6% showed injection sites, 70% indicated injection site rotations, and 60.75% practiced injection site rotations. Education (p<0.001), duration of insulin therapy (p=0.008) and duration of diabetes (p=0.014) had a significant effect on patients’ knowledge level. Education (p<0.001), occupation (p<0.001), duration of insulin therapy (p=0.001), duration of diabetes (p=0.036) and patients’ knowledge levels (p<0.001) were found to have a significant effects on the patients’ practice level. A Mann-Whitney U test also disclosed that residency, ways to get insulin and mocked injection technique during first training had significant effects on patients’ knowledge levels. Conclusion: The current study revealed that patients had moderately adequate knowledge and fair practice levels on insulin storage and handling techniques. Moreover, patients missed important insulin administration skills. Healthcare professionals and stakeholders can play important roles in educating patients thereby improving the knowledge, practice, and administration techniques of patients.


Author(s):  
Di Shen ◽  
Haojie Yu ◽  
Li Wang ◽  
Xiang Chen ◽  
Jingyi Feng ◽  
...  

Microneedles with insulin-loaded glucose-responsive particles are promising to control the blood glucose levels of diabetic patients.


Diabetes ◽  
1989 ◽  
Vol 38 (6) ◽  
pp. 704-709 ◽  
Author(s):  
K. Osei ◽  
T. M. O'Dorisio ◽  
W. B. Malarkey ◽  
E. L. Craig ◽  
S. Cataland

2016 ◽  
Vol 23 (05) ◽  
pp. 576-582
Author(s):  
Rizwana Kitchlew ◽  
Inayat Thaver ◽  
Shehryar Pervez ◽  
Ikram ul Haq

Objective: To determine the trends in insulin injection technique and associatedcomplications in the local diabetic patients. Study Design: Cross-Sectional Descriptive study.Place and Duration of Study: This study was conducted in Department of Medicine at FatimaMemorial College & Hospital Lahore from 25th May 2015 to 25th October 2015. Patientsand Method: Three hundred patients above 18 years of age who presented in outdoor andindoor department of the hospital, gave consent were enrolled. The data was collected throughinterview and relevant physical examination; data was analyzed by using SPSS 20.0 version.Results: 300 diabetics were enrolled; 108 (36%) male and 192 (64%) female. Mean age inmales was 52.8±13.7 and in females was 52.2±11.8. Duration of insulin use was less than5 years in 175 (58%) and 5 years or more in 125 (42%). Insulin syringe of 8 mm gauge wasbeing used by 263 (87%). Abdomen was the injection site in 202 (67%); however, 279 (93%)rotated the injection site. The angle of injection was kept at 90 degrees by 254 (85%). Theneedle was reused for five or more times by 187 (52%) and 216 (72%) were self-injecting. Localcomplications were seen in 105 (35%); out of those pain was most commonly (35 %) reported.Among age groups significant association (p<0.05) was seen in site of insulin delivery, in agemore than 60 years more injected in abdomen. In gender groups more males (83%) wereself-injecting. Significant association (p<0.05) was seen in duration of insulin use and localcomplications. Majority, 126(72%) of those who were on insulin for less than 5 years did nothave complications. Conclusion: Majority of our patients had adopted reasonable techniquehowever repeated reinforcement can further improve appropriate insulin delivery, less wastageof insulin and better glycemic control with less chance of complications.


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