Trace Element Status (Zinc, Copper, Selenium, Iron, Manganese) in Patients with Long-Term Home Parenteral Nutrition

Background: The objective of the present study was to determine concentrations of zinc (Zn), copper (Cu), iron (Fe), selenium (Se) in blood plasma and manganese (Mn) in the whole blood in patients with long-term home parenteral nutrition (HPN) in comparison to the control group. Patients and Methods: We examined 68 patients (16 men and 52 women) aged from 28 to 68 years on a long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily doses of Zn, Cu, Fe, Se and Mn in the last 3 months were determined. Results: No significant differences in blood plasma were found for Zn, Cu and Fe in patients with HPN and in the control group (p > 0.05). The concentration of Mn in whole blood was significantly increased in HPN patients (p < 0.0001), while Se concentration in these patients was significantly decreased (p < 0.005). The concentration of Mn in the whole blood of 16 patients with cholestasis was significantly increased compared to the patients without cholestasis (p < 0.001). The Cu concentration was increased with no statistical significance. Conclusion: In long-term HPN, the status of trace elements in the patients has to be continually monitored and the daily substitution doses of these elements have to be flexibly adjusted. Dosing schedule needs to be adjusted especially in cases of cholestatic hepatopathy. A discussion about the optimal daily dose of Mn in patients on HPN is appropriate. For clinical practice, the availability of a substitution mixture of trace elements lacking Mn would be advantageous.

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Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

Veterinární Medicína ◽

10.17221/1581-vetmed ◽

2011 ◽

Vol 56 (No. 2) ◽

pp. 63-74 ◽

Cited By ~ 13

Author(s):

L. Pavlata ◽

M. Chomat ◽

A. Pechova ◽

L. Misurova ◽

R. Dvorak

Keyword(s):

Blood Plasma ◽

Whole Blood ◽

Average Concentration ◽

The Other ◽

Control Group ◽

Selenium Yeast ◽

Hair Samples ◽

The Impact ◽

Se Status

This paper evaluates the impact of long-term supplementation of different forms of zinc (Zn) and selenium (Se) on the content of these substances in the blood and hair of goats. Two analogous supplementation experiments were performed. 37 goats divided into four groups were used in the first trial with the Zn supplementation. Group A (n = 10) was a control group (with no Zn administered). A further three groups (B, C, D) were supplemented with Zn in various forms. Group B (n = 9) with zinc oxide, Group C (n = 9) with zinc lactate and Group D (n = 9) with zinc chelate. The second trial with Se supplementation was carried out on 20 goats divided into four groups. Group E (n = 5) was a control group. The other three groups were administered Se. Group F (n = 5) was supplied with a selenium lactate-protein complex, Group G (n = 5) with sodium selenite and Group H (n = 5) with selenium yeast. Three months later blood and hair samples were taken from all animals and Zn and Se concentrations were determined in whole blood, plasma, and hair. Glutathione peroxidase (GSH-Px) activity was determined in the Se supplementation trial group. At the end of the trial the Zn concentrations in plasma and whole blood were without major differences between the groups. The plasma concentration of Zn did not increase from the initial value at the start of the trial. In hair the average concentration of Zn was 95.2–100.0 mg/kg<br />in all groups. No conclusive relation was confirmed between the values of Zn in hair and its concentration in blood. The Se concentration in whole blood (µg/l) at the end of trial in supplemented groups (F – 188.8 ± 24.6; G – 197.2 ± 10.9; H – 190.1 ± 26.3) was significantly higher (P < 0.01) than in the control group (E – 103.1 ± 23.5). Similarly, the activity of GSH-Px (µkat/l) was significantly higher in all supplemented groups (F – 872.3 ± 94.8; G – 659.5 ± 176.4; H – 839.8 ± 150.8) than in the control group (E – 379.1 ± 63.5). Se content in hair (µg/kg) was higher also in all trial groups (F – 242.3 ± 41.5; G – 200.5 ± 46.9; H – 270.0 ± 106.8) than in the control group (E – 174.7 ± 38.0). However, it was significantly (P < 0.05) higher only in Group F. A conclusive correlation was identified between the Se concentration in whole blood and its content in hair (r = 0.54; P < 0.05; n = 20). Based on the results it can be concluded that none of the supplemented forms of Zn increased its concentration in blood, plasma and hair. On the other hand, the administration of Se led to an increase in the Se concentration in blood, increased the activity of GSH-Px in whole blood and the Se content in hair. Based on the proven correlation and regression relation between the Se concentration in blood and its content in hair, hair can be considered as a suitable material for the diagnosis of long-term Se status in goats. Goats with sufficient Se status are those that have more than 160 µg/kg of Se in hair dry weight.

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Dosing and Monitoring of Trace Elements in Long-Term Home Parenteral Nutrition Patients

Journal of Parenteral and Enteral Nutrition ◽

10.1177/0148607111413902 ◽

2011 ◽

Vol 35 (6) ◽

pp. 736-747 ◽

Cited By ~ 39

Author(s):

Imad F. Btaiche ◽

Peggy L. Carver ◽

Kathleen B. Welch

Keyword(s):

Trace Elements ◽

Parenteral Nutrition ◽

Home Parenteral Nutrition

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Evaluation of three trace elements preparations used in long-term supplementary home parenteral nutrition

Clinical Nutrition ◽

10.1016/0261-5614(90)90277-y ◽

1990 ◽

Vol 9 ◽

pp. 44

Author(s):

M. Pertkiewicz ◽

K. Majewska ◽

E. Bulska

Keyword(s):

Trace Elements ◽

Parenteral Nutrition ◽

Home Parenteral Nutrition

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PTH-215 Trace elements and vitamin levels in long-term home parenteral nutrition paediatric patients

Gut ◽

10.1136/gutjnl-2015-309861.1103 ◽

2015 ◽

Vol 64 (Suppl 1) ◽

pp. A504.2-A504

Author(s):

R Núñez-Ramos ◽

S Gallego ◽

D Gayda-Pimlott ◽

S Macdonald ◽

J Koeglmeier ◽

...

Keyword(s):

Trace Elements ◽

Parenteral Nutrition ◽

Home Parenteral Nutrition ◽

Paediatric Patients

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Optimization of hypomagnesemia diagnostics as an integral element in paroxysmal atrial fibrillation management strategy

BIO Web of Conferences ◽

10.1051/bioconf/20202202023 ◽

2020 ◽

Vol 22 ◽

pp. 02023

Author(s):

Mikhail Arkhipov ◽

Yakov Bozhko ◽

Nadejda Beloconova ◽

Valentina Kochmasheva ◽

Oksana Chromtsova

Keyword(s):

Atrial Fibrillation ◽

Fatty Acids ◽

Blood Plasma ◽

Paroxysmal Atrial Fibrillation ◽

Whole Blood ◽

Clinical Evidence ◽

Magnesium Content ◽

Control Group ◽

Magnesium Status ◽

In Blood Plasma

Purpose. To study magnesium status of patients having paroxysmal atrial fibrillation (AF) based on the use of an integrated clinical and laboratory approach. Methods. A prospective cohort study included 58 patients of the cardiology department of New Hospital Medical Association. The main group consisted of 32 patients having frequently recurring paroxysmal AF, the control group consisted of 26 patients without paroxysmal rhythm disturbance. The clinical status, Holter ECG monitoring data, the test results for magnesium deficiency (MD) clinical evidence, laboratory evidence of calcium, magnesium in blood plasma and formed elements, magnesium in whole blood, free fatty acids (FFA) and osmolality in blood plasma were assessed. Results. The score obtained when assessing MD clinical evidence was significantly higher in the main group patients compared with the control group (16.5 (11÷21) vs. 13 (8÷15), p<0.001). A statistically significant magnesium decrease in whole blood was revealed in patients having paroxysmal AF (0.54 (0.46÷0.60) vs. 0.61 (0.59÷0.64), p<0.001) and inside formed elements (0.68 (0.53÷1.07) vs. 1.31 (1.07÷1.44), p<0.001), which reflected changes in their magnesium status to a greater extent than the measured plasma cation concentrations. A close correlation between magnesium content in formed elements (intracellularly) and AF paroxysms frequency (Spearman’s rank correlation -0.51, p<0.001) was established. A violation of calcium to magnesium ratio in blood plasma (2.6 (2.5÷2.9) vs. 3.0 (2.8÷3.1), p=0.004) and intracellularly (4.85 (2.62÷9.3) vs. 1.85 (1.57÷2.07), p<0.001) was revealed in patients having AF. It has been shown that complex forming interactions with free fatty acids may affect intracellular calcium and magnesium content.

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Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Clinical Laboratory ◽

10.7754/clin.lab.2015.150622 ◽

2016 ◽

Vol 62 (01+02/2016) ◽

Author(s):

Milan Dastych ◽

Milan JR ◽

Michal Senkyrik

Keyword(s):

Parenteral Nutrition ◽

Whole Blood ◽

Home Parenteral Nutrition

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Whole-blood manganese levels and brain manganese accumulation in children receiving long-term home parenteral nutrition

Pediatric Surgery International ◽

10.1007/s00383-002-0929-6 ◽

2003 ◽

Vol 19 (4) ◽

pp. 268-272 ◽

Cited By ~ 26

Author(s):

Yasushi Iinuma ◽

Masayuki Kubota ◽

Masanori Uchiyama ◽

Minoru Yagi ◽

Satoshi Kanada ◽

...

Keyword(s):

Parenteral Nutrition ◽

Whole Blood ◽

Home Parenteral Nutrition ◽

Blood Manganese

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A Clinical Study of Platelet-Rich Fibrin Combined With Autologous High-Density Fat Transplantation in Augmentation Rhinoplasty

Ear Nose & Throat Journal ◽

10.1177/01455613211016902 ◽

2021 ◽

pp. 014556132110169

Author(s):

Dan Yan ◽

Shuai-Hua Li ◽

An-Li Zhang ◽

Yao Xiao ◽

Ze-Chun Huang

Keyword(s):

Retention Rate ◽

Statistical Significance ◽

High Density ◽

Control Group ◽

Long Term Effects ◽

Fat Transplantation ◽

Augmentation Rhinoplasty ◽

Platelet Rich Fibrin ◽

Autologous Fat

Objective: This study was designed to analyze the clinical effect of autologous fat-granule transplantation in augmentation rhinoplasty and explore methods to improve the fat retention rate. Methods: A total of 70 enrolled patients were randomly divided into 2 groups: the platelet-rich fibrin (PRF) combined with high-density fat transplantation group (combined group) and the conventional fat-granule transplantation group (control group; n = 35 in each group). In the combined group, an appropriate amount of autologous fat was extracted and centrifuged, and the lower layer of high-density fat was taken and mixed with PRF isolated from whole blood for autotransplantation. In the control group, only fat was extracted and centrifuged for transplantation. The patients were followed up with for more than one year to observe the short- and long-term effects, complications, safety, and patient satisfaction. Results: Six months after the operation, the nasal shape was stable, the contour was higher and more stereoscopic than before, the average increase of nasal height was 3.0 mm in the combined group and 2.0 mm in the control group. No complications, such as fat embolism, infection, or necrosis occurred during the 1-year follow-up. The satisfaction rate between the 2 groups has statistical significance ( P < .05). Conclusion: Overall, PRF combined with autologous high-density fat transplantation is simple to perform, has a significantly increased fat-retention rate than the control group, and has stable long-term effects without obvious adverse reactions. A sufficient amount of fat and PRF transplantation can achieve a good orthopedic effect. Thus, this method can be widely used in clinical augmentation rhinoplasty.

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