scholarly journals Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure

2017 ◽  
Vol 41 (3) ◽  
pp. 865-874 ◽  
Author(s):  
Junjie Xiao ◽  
Rongrong Gao ◽  
Yihua Bei ◽  
Qiulian Zhou ◽  
Yanli Zhou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Univariate Logistic Regression Analysis ◽  
Kaplan Meier ◽  
All Cause Mortality

Background/Aims: Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circulating miR-30d as a prognostic marker of survival in patients with AHF has not been explored. Methods: Patients clinically diagnosed with AHF were enrolled and followed up for 1 year. Quantitative reverse transcription polymerase chain reactions were used to determine serum miR-30d levels. The univariate logistic regression analysis and multivariate logistic regression analysis were used to determine the predictors for all-cause mortality in AHF patients. Kaplan–Meier survival analysis was used to analyze the role of miR-30d in prediction of survival. Results: A total of 96 AHF patients were enrolled and followed up for 1 year. Serum miR-30d was significantly lower in AHF patients who expired in the one year follow-up period compared to those who survived. Univariate logistic regression analysis yielded 18 variables that were associated with all-cause mortality in AHF patients, while the multivariate logistic regression analysis identified 4 variables including heart rate, hemoglobin, serum sodium, and serum miR-30d level associated with mortality. ROC curve analysis showed that hemoglobin, heart rate and serum sodium displayed poor prognostic value for AHF (AUCs not higher than 0.700) compared to miR-30d level (AUC = 0.806). Kaplan–Meier survival analysis confirmed that patients with higher serum miR-30d levels had significantly lower mortality (P=0.001). Conclusion: In conclusion, this study shows evidence for the predictive value of circulating miR-30d as 1-year all-cause mortality in AHF patients. Large multicentre studies are further needed to validate our findings and accelerate the transition to clinical utilization.

scholarly journals Serum Irisin Predicts Mortality Risk in Acute Heart Failure Patients

2017 ◽  
Vol 42 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Shutong Shen ◽  
Rongrong Gao ◽  
Yihua Bei ◽  
Jin Li ◽  
Haifeng Zhang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Curve Analysis ◽  
Multivariate Logistic Regression ◽  
Roc Curve Analysis ◽  
Kaplan Meier ◽  
All Cause Mortality

Background/Aims: Irisin is a peptide hormone cleaved from a plasma membrane protein fibronectin type III domain containing protein 5 (FNDC5). Emerging studies have indicated association between serum irisin and many major chronic diseases including cardiovascular diseases. However, the role of serum irisin as a predictor for mortality risk in acute heart failure (AHF) patients is not clear. Methods: AHF patients were enrolled and serum was collected at the admission and all patients were followed up for 1 year. Enzyme-linked immunosorbent assay was used to measure serum irisin levels. To explore predictors for AHF mortality, the univariate and multivariate logistic regression analysis, and receiver-operator characteristic (ROC) curve analysis were used. To determine the role of serum irisin levels in predicting survival, Kaplan-Meier survival analysis was used. Results: In this study, 161 AHF patients were enrolled and serum irisin level was found to be significantly higher in patients deceased in 1-year follow-up. The univariate logistic regression analysis identified 18 variables associated with all-cause mortality in AHF patients, while the multivariate logistic regression analysis identified 2 variables namely blood urea nitrogen and serum irisin. ROC curve analysis indicated that blood urea nitrogen and the most commonly used biomarker, NT-pro-BNP, displayed poor prognostic value for AHF (AUCs ≤ 0.700) compared to serum irisin (AUC = 0.753). Kaplan-Meier survival analysis demonstrated that AHF patients with higher serum irisin had significantly higher mortality (P<0.001). Conclusion: Collectively, our study identified serum irisin as a predictive biomarker for 1-year all-cause mortality in AHF patients though large multicenter studies are highly needed.

scholarly journals Αξιολόγηση του μετεγχειρητικού πόνου και άγχους σε παιδά με φίμωση

2014 ◽  
Author(s):  
Στυλιανή Τσαμουδάκη
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
T Test ◽  
Multivariate Logistic Regression ◽  
Univariate Logistic Regression Analysis

Σκοπός. Σκοπός της παρούσας μελέτης ήταν να εκτιμήσει το μετεγχειρητικό άγχoς και πόνο σε παιδιά που χειρουργήθηκαν για φίμωση και να συσχετίσει την παρουσία τους με διάφορους εκλυτικούς παράγοντες.Ασθενείς και Μέθοδος. Στην εργασία αυτή συμπεριελήφθησαν αγόρια, που προσήλθαν να χειρουργηθούν για φίμωση. Η αντιμετώπιση της φίμωσης έγινε με μια από τις παρακάτω τεχνικές: κλασσική περιτομή, πλαστική ακροποσθίας χωρίς συρραφή και πλαστική ακροποσθίας με συρραφή. Η αναλγησία κατά την επέμβαση έγινε με χορήγηση υπόθετου παρακεταμόλης ή/και περιοχική αναλγησία. Η εκτίμηση του μετεγχειρητικού πόνου έγινε με τη χρήση της συμπεριφορικής μέτρησης του πόνου FLACC, και την κλίμακα FACES σε συνδυασμό με οπτική αναλογική κλίμακα δέκα σημείων (VAS). Η παρουσία του μετεγχειρητικού άγχους εκτιμήθηκε από την παρουσία διαταραχών συμπεριφοράς του παιδιού στο σπίτι. Στην τελική αξιολόγηση του μετεγχειρητικού πόνου και άγχους λαμβάνονταν υπόψη οι εξής παράγοντες: η ηλικία του παιδιού, το κοινωνικό και μορφωτικό επίπεδο των γονέων, η προεγχειρητική ενημέρωση του παιδιού, η παρουσία άλλων αδερφών στην οικογένεια, η προηγούμενη εμπειρία του παιδιού από χειρουργική επέμβαση, η χειρουργική τεχνική, η παρουσία άμεσων μετεγχειρητικών επιπλοκών και η εθνικότητα. Για το σκοπό αυτό, χορηγήθηκε ειδικό ερωτηματολόγιο στους γονείς μετά τη χειρουργική επέμβαση.Η επεξεργασία των δεδομένων έγινε με τη βοήθεια του στατιστικού πακέτου SPSS 16.0 και την εφαρμογή της στατιστικής δοκιμασίας χ2-test, t-test και Anova. Για την αξιολόγηση του μετεγχειρητικού άγχους και τους παράγοντες που επιδρούν στην παρουσία του, χρησιμοποιήθηκε μονοπαραγοντική (Univariate Logistic Regression Analysis) και στη συνέχεια πολυπαραγοντική (Multivariate Logistic Regression Analysis) ανάλυση έχοντας ως βάση το μοντέλο των παραμέτρων ερωτηματολογίου που συμπληρώθηκε από τους γονείς των παιδιών. Με τη χρήση του ίδιου στατιστικού μοντέλου, εκτιμήθηκαν επίσης οι παράγοντες που επηρεάζουν την εμφάνιση πόνου μετεγχειρητικά. Το επίπεδο της στατιστικής σημαντικότητας τέθηκε στο p<0,05. ΑΠΟΤΕΛΕΣΜΑΤΑ. Τον πληθυσμό της μελέτης αποτέλεσαν 301 αγόρια ηλικίας δύο έως δεκατεσσάρων χρόνων. Όσον αφορά τα κλινικά χαρακτηριστικά των ασθενών, συγγενή φίμωση είχαν 285/301 (94.7%) και επίκτητη 16 (5.3%). Η αντιμετώπιση της φίμωσης έγινε με κλασσική περιτομή σε 109 (36.2%) αγόρια, πλαστική ακροποσθίας χωρίς συρραφή σε 93 (30.9%) και πλαστική ακροποσθίας με συρραφή σε 99 (32.9%) αγόρια αντίστοιχα.Η πολυπαραγοντική ανάλυση όσον αφορά την παρουσία πόνου μετεγχειρητικά, έδειξε ότι το αίσθημα του πόνου συσχετίζεται στατιστικά σημαντικά με τα παιδιά που υποβλήθησαν σε κλασσική περιτομή ή πλαστική ακροποσθίας με συρραφή σε σύγκριση με αυτά που εφαρμόσθηκε πλαστική ακροποσθίας χωρίς συρραφή, και στα παιδιά με επιπλοκές (p<0.001). Όσον αφορά το μετεγχειρητικό άγχος, η πολυπαραγοντική ανάλυση έδειξε ότι περισσότερες πιθανότητες εμφάνισης άγχους μετεγχειρητικά έχουν τα παιδιά που δεν έχουν αδέλφια, τα παιδιά άλλης εθνικότητας (εκτός της ελληνικής), καθώς και τα παιδιά με προηγούμενο ιστορικό ιατρικων χειρισμών. ΣΥΜΠΕΡΑΣΜΑΤΑ. Η μελέτη αυτή έδειξε ότι τα παιδιά που εμφανίζουν μετεγχειρητικό άγχος είναι παιδιά που δεν έχουν αδέλφια, τα παιδιά των ευαίσθητων κοινωνικά ομάδων όπως αυτά των μεταναστών και τα παιδιά που έχουν δυσάρεστες εμπειρίες από προηγούμενες επεμβάσεις. Όσον αφορά το μετεγχειρητικό αίσθημα πόνου, φαίνεται ότι σημαντικό ρόλο έχουν η εφαρμοζόμενη τεχνική και η παρουσία μετεγχειρητικών επιπλοκών.

scholarly journals Predictive factors for preeclampsia in pregnant women: a unvariate and multivariate logistic regression analysis.

2012 ◽  
Vol 59 (4) ◽  
Author(s):  
Ashraf Direkvand-Moghadam ◽  
Afra Khosravi ◽  
Kourosh Sayehmiri
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Demographic Variables ◽  
Regression Analyses ◽  
Multivariate Logistic Regression ◽  
History Of

Several risk factors have been used to predict preeclampsia. The role of some risk factors as predictors associated with preeclampsia among Iranian women was analyzed in the present study using logistic regression. 610 women attending the obstetric ward of Mustafa hospital in Ilam were enrolled in this study. Demographic variables such as age, Body Mass Index (BMI), medical and obstetrics variables such as education, number of pregnancy, abortion and parity from May to September 2010 were analyzed. We used the unvaried and multiple logistic regression analyses to predict preeclampsia. The history of preeclampsia, hypertension, and infertility showed to be good independent predicator variables for preeclampsia using multivariate logistic regression analysis (OR was 5.46, 2.34 and 3.07 respectively). Area Under the Receiver Operation Character (AUROC) was estimated to be 0.67 (95% CI 0.59-0.67, p

scholarly journals Efficacy of flurbiprofen axetil for preventing postanesthetic shivering in patients undergoing gynecologic laparotomy surgeries

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Atsushi Kotera
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Postoperative Pain ◽  
Logistic Regression Analysis ◽  
Pain Control ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Postoperative Pain Control ◽  
Flurbiprofen Axetil ◽  
Postanesthetic Shivering

Abstract Background Postanesthetic shivering is an unpleasant adverse event in surgical patients. A nonsteroidal anti-inflammatory drug has been reported to be useful in preventing postanesthetic shivering in several previous studies. The aim of this study was to evaluate the efficacy of flurbiprofen axetil being a prodrug of a nonsteroidal anti-inflammatory drug for preventing postanesthetic shivering in patients undergoing gynecologic laparotomy surgeries. Method This study is a retrospective observational study. I collected data from patients undergoing gynecologic laparotomy surgeries performed between October 1, 2019, and September 30, 2020, at Kumamoto City Hospital. All the patients were managed with general anesthesia with or without epidural analgesia. The administration of intravenous 50 mg flurbiprofen axetil for postoperative pain control at the end of the surgery was left to the individual anesthesiologist. The patients were divided into two groups: those who had received intravenous flurbiprofen axetil (flurbiprofen group) and those who had not received intravenous flurbiprofen axetil (non-flurbiprofen group), and I compared the frequency of postanesthetic shivering between the two groups. Additionally, the factors presumably associated with postanesthetic shivering were collected from the medical charts. Intergroup differences were assessed with the χ2 test with Yates’ correlation for continuity category variables. The Student’s t test was used to test for differences in continuous variables. Furthermore, a multivariate logistic regression analysis was performed to elucidate the relationship between the administration of flurbiprofen axetil and the incidence of PAS. Results I retrospectively examined the cases of 141 patients aged 49 ± 13 (range 21-84) years old. The overall postanesthetic shivering rate was 21.3% (30 of the 141 patients). The frequency of postanesthetic shivering in the flurbiprofen group (n = 31) was 6.5%, which was significantly lower than that in the non-flurbiprofen group (n = 110), 25.5% (p value = 0.022). A multivariate logistic regression analysis showed that administration of flurbiprofen axetil was independently associated with a reduced incidence of postanesthetic shivering (odds ratio 0.12; 95% confidence interval, 0.02-0.66, p value = 0.015). Conclusions My result suggests that intraoperative 50 mg flurbiprofen axetil administration for postoperative pain control is useful to prevent postanesthetic shivering in patients undergoing gynecologic laparotomy surgeries.

scholarly journals Risk factors for tissue expander infection in scar reconstruction: a retrospective cohort study of 2374 consecutive cases

2020 ◽  
Vol 8 ◽  
Author(s):  
Chen Dong ◽  
Minhui Zhu ◽  
Luguang Huang ◽  
Wei Liu ◽  
Hengxin Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Treatment Failure ◽  
Logistic Regression Analysis ◽  
Disease Duration ◽  
Multivariate Logistic Regression Analysis ◽  
Tissue Expansion ◽  
Multivariate Logistic Regression ◽  
Hematoma Evacuation

Abstract Background Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes; however, the complications that emerge from tissue expansion hinder repair. Infection is considered a major complication of tissue expansion. This study aimed to analyze the perioperative risk factors for expander infection. Methods A large, retrospective, single-institution observational study was carried out over a 10-year period. The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction. Demographics, etiological data, expander-related characteristics and postoperative infection were assessed. Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection. In addition, we conducted a sensitivity analysis for treatment failure caused by infection as an outcome. Results A total of 2374 expanders and 148 cases of expander infection were assessed. Treatment failure caused by infection occurred in 14 expanders. Multivariate logistic regression analysis identified that disease duration of ≤1 year (odds ratio (OR), 2.07; p &lt; 0.001), larger volume of expander (200–400 ml vs &lt;200 ml; OR, 1.74; p = 0.032; &gt;400 ml vs &lt;200 ml; OR, 1.76; p = 0.049), limb location (OR, 2.22; p = 0.023) and hematoma evacuation (OR, 2.17; p = 0.049) were associated with a high likelihood of expander infection. Disease duration of ≤1 year (OR, 3.88; p = 0.015) and hematoma evacuation (OR, 10.35; p = 0.001) were so related to high risk of treatment failure. Conclusions The rate of expander infection in patients undergoing scar reconstruction was 6.2%. Disease duration of &lt;1 year, expander volume of &gt;200 ml, limb location and postoperative hematoma evacuation were independent risk factors for expander infection.

Relationship Between Rotator Cuff Tears and Scapular Morphology

2021 ◽  
Author(s):  
Yoshihiro Nakamura ◽  
Shin Yokoya ◽  
Yuki Matsubara ◽  
Yohei Harada ◽  
Nobuo Adachi
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Rotator Cuff ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Lateral View ◽  
Multivariate Logistic Regression ◽  
Inferior Angle ◽  
Scapular Spine ◽  
Scapular Body

Abstract Background The purpose of this study was to identify differences in the morphology of the scapula according to the presence or absence of a rotator cuff tear (RCT). Methods One hundred and three shoulders with and 87 shoulders without RCTs were included in this study. The critical shoulder angle (CSA) and lateral acromion angle in the frontal view and the acromial coverage angle (ACA) and coracoid and scapular spine angle (CSSA) in the lateral view were evaluated using three-dimensional computed tomography. The glenoid anterior tilt, anterior acromial projection angle (AAPA), coracoid process angle, scapular spine angle (SSA) and inferior angle angle (IAA) with respect to the scapular plane were measured in the lateral view. The morphological parameters of the scapula associated with RCT were statistically analysed using a multivariate logistic regression analysis. Results In univariate logistic regression analysis, CSA, ACA, CSSA, AAPA, SSA and IAA were significantly different between shoulders with and without RCTs. In multivariate logistic regression analysis, CSA and IAA were greater in shoulders with RCT and were significantly associated with this condition. Conclusion To the best of our knowledge, this is the first study to focus on the relationship between RCT and the scapular body. RCT cases were characterised by a greater curvature of the scapular body in addition to CSA.

Confirmatory germline testing for presumed germline pathogenic variants using tumor-only testing.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e22524-e22524
Author(s):  
Tomohiro Kondo ◽  
Takahiro Yamada ◽  
Masahiro Yoshioka ◽  
Masakazu Nishigaki ◽  
Yoshihiro Yamamoto ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Tumor Board ◽  
Genomic Profiling ◽  
Multivariate Logistic Regression ◽  
Pathogenic Variants ◽  
Comprehensive Genomic Profiling ◽  
Germline Testing

e22524 Background: Presumed germline pathogenic variants (PGPVs) can be detected in tumor tissues using comprehensive genomic profiling. Clinicians and patients can decide whether to conduct confirmatory germline testing or not. However, the promoting and obstructive factors for confirmatory germline testing are unclear. Methods: This single institutional retrospective study aimed to identify factors related to confirmatory germline testing in patients with PGPVs. Between April 2015 and April 2019, 270 consecutive patients with cancers of unknown primary site, rare tumors, or solid tumors refractory to standard chemotherapy, who underwent tumor-only comprehensive genomic profiling were reviewed. PGPVs were proposed to be disclosed as variants to the patients by our institutional molecular tumor board. Univariate logistic regression analysis was conducted to investigate the relationship between each patient’s characteristics and confirmatory germline testing. Factors showing a statistical relationship (p < 0.10 in univariate analyses) were included in multivariate logistic regression analysis with a backward selection of variables. Statistical significance was set at p < 0.05. Results: Of the 270 patients who underwent tumor-only comprehensive genomic profiling, 77 possessed PGPVs. The most common PGPVs were TP53 (n = 56), APC (n = 9), PTEN (n = 7), RB1 (n = 6), and BRCA2 (n = 6). Among the 77 patients, only 11 (14.3%) chose to undergo confirmatory germline testing. Multivariate logistic regression analysis revealed that the person disclosing the results (experienced oncologists with knowledge of cancer genome medicine vs. others, odds ratio [OR]: 27.7, 95% confidence interval [CI]: 4.60–167) and study period (OR: 0.110, 95% CI: 0.015–0.787) were independently and significantly associated with confirmatory germline testing. Conclusions: These findings indicate that fostering genomic competency in oncologists and collaborating with genetic experts would facilitate cancer patients and their families to receive genetic medical services in the process of cancer genomic profiling.

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