scholarly journals Transversal Width of Mandibular Bone and Neurosensory Disturbance after Bilateral Sagittal Splitting Ramus Osteotomy

2017 ◽  
Vol 2 (3) ◽  
pp. 1-9
Author(s):  
Yuichiro Takaku ◽  
Masayuki Takano ◽  
Shuichiro Yamashita ◽  
Kenichi Fukuda
Keyword(s):  
Ct Images ◽  
Mental Nerve ◽  
Mandibular Angle ◽  
Second Molar ◽  
Bone Width ◽  
Region I ◽  
Preoperative Ct ◽  
Transversal Width ◽  
Region Ii ◽  
Neurosensory Disturbance

Objective: This study evaluated the condition of mandibular cancellous and cortical bone on computed tomography (CT) images in order to investigate its relationship with the incidence of neurosensory disturbances (NSD) in the mental nerve region after bilateral sagittal splitting ramus osteotomy (BSSRO). Methods: BSSRO was performed on 58 lateral mandibles in 29 patients. From preoperative CT images, the width endpoints of the transversal bone were measured in region I immediately inferior to the mandibular foramen, region II in the mandibular angle region, and region III distal to the lower second molar. The incidence of NSD immediately after surgery and the residual NSD rate at 1, 3, and 6 months after surgery were investigated. The correlation between incidence of NSD in the mental nerve region and each transversal bone width endpoint immediately after and at 6 months after surgery was also comparatively evaluated. Results: The overall incidence of NSD immediately after surgery was 67.2% (39/58 sides) and the overall residual NSD rate at 1, 3, and 6 months after surgery was 53.4% (31/58 sides), 31.0% (18/58 sides), and 17.2% (10/58 sides), respectively. No significant differences were observed for any width endpoints of the transversal bone measured at regions I or III, but the transversal width of the entire mandible was significantly different in region II between patients with and without NSD at 6 months after surgery (p < 0.05). Conclusion: These findings demonstrate that the transversal width of the entire mandible may be an important factor in predicting NSD incidence.

scholarly journals Tomographic mapping of buccal shelf area for optimum placement of bone screws: A three-dimensional cone-beam computed tomography evaluation

2019 ◽  
Vol 9 ◽  
pp. 241-245
Author(s):  
Neeraj Eknath Kolge ◽  
Vivek J. Patni ◽  
Sheetal S. Potnis
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Bone Screws ◽  
Neurovascular Bundle ◽  
Cone Beam ◽  
Shelf Area ◽  
Bone Screw ◽  
Second Molar ◽  
Bone Width ◽  
Mandibular Second Molar

Introduction: Buccal shelf bone screws have become increasingly popular as a preferred method of skeletal anchorage in the mandibular arch. Anatomic variations and clinical experience suggest that width and slope of the bone at buccal shelf vary in different population groups, with some individual variations. Aims and Objectives: The objective of this study was to evaluate angulation of the bone screw of mandibular buccal shelf area, total bone width, thickness of the cortical bone, and proximity to neurovascular structures. Materials and Methods: Cone-beam computed tomography scans were used to obtain measurements of the buccal shelf region of 35 patients (18 females, 17 males; mean age, 23.6 years). Measurements were taken at three locations (L1, L2, and L3) and total bone width was measured at two levels from the cementoenamel junction (CEJ, H1 and H2). Bone screws were virtually placed and their proximity evaluated from digitally traced inferior alveolar neurovascular bundle. Results: Permissible angulation for placement of buccal shelf bone screw considering the safety distance from the root and avoiding excessive buccal projection to minimize cheek irritation was found to be 74.48 (SD ± 4.26). Total bone width was maximum at the distobuccal cusp of mandibular second molar (L3H2; 6.40 ± 1.35) when measured at the level of 8 mm from the CEJ. Bone screws were well within the safety range from causing any iatrogenic damage to the inferior alveolar neurovascular bundle at all the three aforementioned locations. Conclusion: Thus, area buccal to the mandibular second molar region seems to be the most favorable site for placement of buccal shelf bone screws in Indian patients.

Plasmodium falciparum EBA-175 kDa protein peptides which bind to human red blood cells

Parasitology ◽  
2000 ◽  
Vol 120 (3) ◽  
pp. 225-235 ◽  
Author(s):  
L. E. RODRIGUEZ ◽  
M. URQUIZA ◽  
M. OCAMPO ◽  
J. SUAREZ ◽  
H. CURTIDOR ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Binding Activity ◽  
Ligand Interaction ◽  
Merozoite Invasion ◽  
Human Red Blood Cells ◽  
Affinity Constants ◽  
Region I ◽  
Binding Peptides ◽  
V Region ◽  
Region Ii

Solid experimental evidence indicates that EBA-175 is used as a ligand by the Plasmodium falciparum merozoite to bind to human RBC, via different binding processing fragments. Using synthetic peptides and specific receptor-ligand interaction methodology, we have identified 6 high-activity binding sequences from the EBA-175 CAMP strain; peptide 1758 (KSYGTPDNIDKNMSLIHKHN), located in the so-called region I for which no binding activity has been reported before, peptides 1779 (NIDRIYDKNLLMIKEHILAI) and 1783 (HRNKKNDKLYRDEWWKVIKK), located in region II, in a sub-region known as 5′ Cys F2, previously reported as being a binding region, and peptides 1814 (DRNSNTLHLKDYRNEENERH), 1815 (YTNQNINISQERDLQKHGFH) and 1818 (NNNFNNIPSRYNLYDKKLDL), in region III–V where antibodies inhibit merozoite invasion of erythrocytes. The affinity constants were between 60 and 180 nM and the critical amino acids involved in the binding were identified. The binding of these peptides to enzyme-treated RBC was analysed; binding of peptide 1814, located in the III–V region, was found to be sialic acid dependent. Some of these high binding peptides were able to inhibit in vitro merozoite invasion and to block the binding of recombinant RII-EBA to RBC. Several of these peptides are located in regions recognized by protective immune clusters of merozoites (ICMs) eluted antibodies.

A rare case of a systemic-to-pulmonary veno-venous connection: a pause during development of pulmonary and systemic venous separation

2017 ◽  
Vol 27 (5) ◽  
pp. 1011-1013
Author(s):  
Jae Gun Kwak ◽  
Kyung-Hee Kim ◽  
Chang-Ha Lee
Keyword(s):  
Left Atrium ◽  
Pulmonary Vein ◽  
Rare Case ◽  
Ct Images ◽  
Atrial Septum ◽  
Caval Vein ◽  
Superior Caval Vein ◽  
Preoperative Ct ◽  
Diameter Orifice

AbstractA 45-year-old man with dyspnoea and palpitations exhibited a unique systemic-to-pulmonary veno-venous connection on preoperative CT images. A window of 31.5-mm diameter was evident between the superior caval vein and the middle pulmonary vein, which was normally connected to the left atrium via a 30-mm-diameter orifice. The atrial septum was intact.

Giant dielectric constant and high-temperature dielectric relaxation properties in La-doped SrTiO3 ceramics

2020 ◽  
pp. 2150046
Author(s):  
Tianyang Liu ◽  
Xiaofei Wang ◽  
Congcong Li ◽  
Bowen Shen ◽  
Mingyan Yao ◽  
...  
Keyword(s):  
Dielectric Constant ◽  
High Temperature ◽  
Temperature Region ◽  
Relaxation Processes ◽  
Doping Amount ◽  
Solid State Method ◽  
Giant Dielectric ◽  
Region I ◽  
Giant Dielectric Constant ◽  
Region Ii

[Formula: see text] (SLTO) ceramics ([Formula: see text] = 0.05, 0.10, 0.15) were prepared with giant dielectric constant by the traditional solid-state method at 1350[Formula: see text]C. The temperature dependence of the dielectric constant was obtained at the temperature ranging from 29[Formula: see text]C to 500[Formula: see text]C and the frequency ranging from 2 kHz to 2 MHz. Two sets of relaxation peaks appear in the low temperature (region I) and the high temperature (region II), respectively. For region I, we conclude that the relaxation behavior is related to the oxygen vacancy migration. For region II, the two relaxation processes are caused by grain boundary for high frequency and Sr or Ti defects at grain interior for low frequency. With the doping amount reaching 0.15, the relaxation peaks disappear and become a common phase transition because of the aggravation of lattice distortion. These possible physical mechanisms of two sets of relaxation peaks are briefly discussed.

Design and Implementation of a Site for a One-Ångstrom TEM

1997 ◽  
Vol 3 (S2) ◽  
pp. 1177-1178
Author(s):  
John H. Turner ◽  
M.A. O'Keefe ◽  
M.A. O'Keefe
Keyword(s):  
Field Emission ◽  
Acoustic Noise ◽  
Mechanical Vibration ◽  
Region I ◽  
Critical Requirement ◽  
The One ◽  
A Site ◽  
Region Ii ◽  
Critical Direction ◽  
Suitable Environment

The National Center for Electron Microscopy has recently acquired a field-emission TEM to form thebasis of a project to achieve a resolution of one Ångstrom. To reach this resolution, both instrumental and environmental factors need to be considered. We have designed and constructed a new building to provide a suitable environment for this instrument, with emphasis on providing isolation from external influences detrimental to the achievement of ultra-high resolution. Such influences include mechanical vibration, temperature fluctuations, acoustic noise, and stray electromagnetic fields.The microscope chosen for the one-Ångstrom project is a Philips CM300 Ultra-Twin equipped with a field-emission gun. Pre-installation specifications provided by Philips for this 1.7Å-resolution TEM specify maximum-allowable values for vibration levels in three mutually-perpendicular directions. In the most critical direction (console left to right), vibration is required to remain below 0.8)μm/sec in the frequency range from 1Hz to 5Hz, although allowed to rise to 6μm/sec above 10Hz (Region I in fig. 1). Even when resolution is not a critical requirement, vibration must be minimized at 2.5Hz (Region II in fig.1).

scholarly journals Regional Characteristics of Long-Term Variability of Summer Precipitation in the Poyang Lake Basin and Possible Links with Large-Scale Circulations

Atmosphere ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1033
Author(s):  
Hua Zhu ◽  
Handan He ◽  
Hongxiang Fan ◽  
Ligang Xu ◽  
Jiahu Jiang ◽  
...  
Keyword(s):  
Large Scale ◽  
Poyang Lake ◽  
Summer Precipitation ◽  
Climate Indices ◽  
Lake Basin ◽  
Regional Characteristics ◽  
Poyang Lake Basin ◽  
Region I ◽  
Region Ii

Understanding the spatiotemporal regime of summer precipitation at local scales plays a key role in regional prevention and mitigation of floods disasters and water resources management. Previous works focused on spatiotemporal characteristics of a region as a whole but left the influence of associated physical factors on sub-regions unexplored. Based on the precipitation data of 77 meteorological stations in the Poyang Lake basin (PYLB) from 1959 to 2013, we have investigated regional characteristics of summer precipitation in the PYLB by integrating the rotated empirical orthogonal function (REOF) analysis with hierarchical clustering algorithm (HCA). Then the long-term variability of summer precipitation in sub-regions of the PYLB and possible links with large-scale circulations was investigated using multiple trend analyses, wavelet analysis and correlation analysis. The results indicate that summer precipitation variations in the PYLB were of very striking regional characteristics. The PYLB was divided into three independent sub-regions based on two leading REOF modes and silhouette coefficient (SC). These sub-regions were located in northern PYLB (sub-region I), central PYLB (sub-region II), and southern PYLB (sub-region III). The summer precipitation in different sub-regions exhibited distinct variation trends and periodicities, which was associated with different factors. All sub-regions show no trends over the whole period 1959–2013, rather they show trends in different periods. Trends per decade in annual summer precipitation in sub-region I and sub-region II were consistent for all periods with different start and end years. The oscillations periods with 2–3 years were found in summer precipitation of all the three sub-regions. Summer precipitation in sub-region I was significantly positively correlated with the previous Indian Ocean Dipole (IOD) event, but negatively correlated with East Asian Summer Monsoon (EASM). While summer precipitation in sub-region II and sub-region III showed weak teleconnections with climate indices. All of the results of this study are conducive to further understand both the regional climate variations in the PYLB and response to circulation patterns variations.

scholarly journals DNase I footprinting shows three protected regions in the promoter of the rRNA genes of Xenopus laevis.

1985 ◽  
Vol 5 (2) ◽  
pp. 313-319 ◽  
Author(s):  
M Dunaway ◽  
R H Reeder
Keyword(s):  
Xenopus Laevis ◽  
Base Pair ◽  
Transcription Initiation ◽  
Protein S ◽  
Dnase I ◽  
Rrna Genes ◽  
Xenopus Laevis Oocytes ◽  
Dnase I Footprinting ◽  
Region I ◽  
Region Ii

Extracts prepared from Xenopus laevis oocytes contain a protein(s) which specifically protects three discrete regions of the RNA polymerase I promoter from digestion by DNase I. Protected region I, from nucleotide +15 to nucleotide -10, spans the site of transcription initiation. Protected region II extends from nucleotide -70 to nucleotide -100 relative to initiation, falling within a 42-base-pair sequence which is homologous to the 60/81-base-pair repeated elements which occur outside of the promoter in the spacer. Protected region III is upstream of region II, from nucleotide -120 to nucleotide -140. All three regions correlate with sequences known from deletion studies to be important for promoter function. Deletion mutants which retain either region I or regions II and III together footprint normally. Deletion of region III, however, reduces but does not eliminate footprinting on region II, suggesting either that one protein binds to both regions or that the proteins which bind to these sites interact with each other.

scholarly journals Differential Roles of Individual Domains in Selection of Secretion Route of a Streptococcus parasanguinis Serine-Rich Adhesin, Fap1

2007 ◽  
Vol 189 (21) ◽  
pp. 7610-7617 ◽  
Author(s):  
Qiang Chen ◽  
Baiming Sun ◽  
Hui Wu ◽  
Zhixiang Peng ◽  
Paula M. Fives-Taylor
Keyword(s):  
Signal Peptide ◽  
Wild Type ◽  
Secretion Pathway ◽  
C Terminus ◽  
Region I ◽  
Minimal Sequences ◽  
Region Ii ◽  
Dependent Pathway ◽  
Selection Of ◽  
Streptococcus Parasanguinis

ABSTRACT Fimbria-associated protein 1 (Fap1) is a high-molecular-mass glycosylated surface adhesin required for fimbria biogenesis and biofilm formation in Streptococcus parasanguinis. The secretion of mature Fap1 is dependent on the presence of SecA2, a protein with some homology to, but with a different role from, SecA. The signals that direct the secretion of Fap1 to the SecA2-dependent secretion pathway rather than the SecA-dependent secretion pathway have not yet been identified. In this study, Fap1 variants containing different domains were expressed in both secA2 wild-type and mutant backgrounds and were tested for their ability to be secreted by the SecA- or SecA2-dependent pathway. The presence or absence of the cell wall anchor domain (residues 2531 to 2570) at the C terminus did not alter the selection of the Fap1 secretion route. The Fap1 signal peptide (residues 1 to 68) was sufficient to support the secretion of a heterologous protein via the SecA-dependent pathway, suggesting that the signal peptide was sufficient for recognition by the SecA-dependent pathway. The minimal sequences of Fap1 required for the SecA2-dependent pathway included the N-terminal signal peptide, nonrepetitive region I (residues 69 to 102), and part of nonrepetitive region II (residues 169 to 342). The two serine-rich repeat regions (residues 103 to 168 and 505 to 2530) were not required for Fap1 secretion. However, they were both involved in the specific inhibition of Fap1 secretion via the SecA-dependent pathway.

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