Evaluation of Factors Affecting Lymph Node Metastasis in Clinical Stage I-II Epithelial Ovarian Cancer

2018 ◽  
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Suat C. Ulukent ◽  
Osman Aşıcıoğlu ◽  
...  
2017 ◽  
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2000 ◽  
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Vol 27 (1) ◽  
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Chang Yang ◽  
Tianbo Liu ◽  
Bairong Xia ◽  
Lina Gu ◽  
Ge Lou

ObjectiveThis study aimed to reveal whether collagen triple helix repeat containing 1 (CTHRC1) was a predictor of peritoneal and lymph node metastases in epithelial ovarian cancer, which had not been researched by others previously.Materials and MethodsWestern blot analysis showed that dramatic overexpression of CTHRC1 could be seen in most metastatic tissues. Univariate and multivariate logistic regression analyses demonstrated that overexpression of CTHRC1 was linked with peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer.ResultsThe negative and sensitivity-predictive values of CTHRC1 staining were excellent for both lymph node and peritoneal metastases. The odds ratio of high versus low staining for peritoneal dissemination was 2.250 (95% confidence interval, 1.126–4.496), and that for lymph node metastasis was 13.102 (95% confidence interval, 6.036–28.439).ConclusionsCollagen triple helix repeat containing 1 may potentially be used as a predictive marker of clinical progression in ovarian cancer either alone or in combination with other markers.


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