scholarly journals Inosine – a Multifunctional Treatment for Complications of Neurologic Injury

2018 ◽  
Vol 49 (6) ◽  
pp. 2293-2303 ◽  
Author(s):  
Claire Doyle ◽  
Vivian Cristofaro ◽  
Maryrose P. Sullivan ◽  
Rosalyn M. Adam

Spinal cord injury (SCI) caused by trauma or disease leads to motor and sensory abnormalities that depend on the level, severity and duration of the lesion. The most obvious consequence of SCI is paralysis affecting lower and upper limbs. SCI also leads to loss of bladder and bowel control, both of which have a deleterious, life-long impact on the social, psychological, functional, medical and economic well being of affected individuals. Currently, there is neither a cure for SCI nor is there adequate management of its consequences. Although medications provide symptomatic relief for the complications of SCI including muscle spasms, lower urinary tract dysfunction and hyperreflexic bowel, strategies for repair of spinal injuries and recovery of normal limb and organ function are still to be realized. In this review, we discuss experimental evidence supporting the use of the naturally occurring purine nucleoside inosine to improve the devastating sequelae of SCI. Evidence suggests inosine is a safe, novel agent with multifunctional properties that is effective in treating complications of SCI and other neuropathies.

Author(s):  
Quan Gao ◽  
Orlando Woods ◽  
Xiaomei Cai

This paper explores how the intersection of masculinity and religion shapes workplace well-being by focusing on Christianity and the social construction of masculinity among factory workers in a city in China. While existing work on public and occupational health has respectively acknowledged masculinity’s influences on health and the religious and spiritual dimensions of well-being, there have been limited efforts to examine how variegated, and especially religious, masculinities influence people’s well-being in the workplace. Drawing on ethnography and in-depth interviews with 52 factory workers and 8 church leaders and factory managers, we found that: (1) Variegated masculinities were integrated into the factory labor regime to produce docile and productive bodies of workers. In particular, the militarized and masculine cultures in China’s factories largely deprived workers of their dignity and undermined their well-being. These toxic masculinities were associated with workers’ depression and suicidal behavior. (2) Christianity not only provided social and spiritual support for vulnerable factory workers, but also enabled them to construct a morally superior Christian manhood that phytologically empowered them and enhanced their resilience to exploitation. This paper highlights not only the gender mechanism of well-being, but also the ways religion mediates the social-psychological construction of masculinity.


2003 ◽  
Vol 56 (2) ◽  
pp. 89-112 ◽  
Author(s):  
Chang-Ming Hsieh

Although the effects of income and age on subjective well-being have been widely studied, research on the effects of income and age on financial satisfaction, a major life domain to which income has direct relevance, remains limited. Analyzing data from the General Social Surveys, this article empirically examined the effects of income and age on financial satisfaction. These findings suggest that the social-psychological mechanisms underlying the age differences in the effects of income on financial satisfaction might not reflect a clear-cut status attainment versus status maintenance framework. The findings also served to caution future financial satisfaction research in the choice of income measures and the age grouping.


Pragmatics ◽  
2001 ◽  
Vol 11 (1) ◽  
pp. 31-61 ◽  
Author(s):  
William Turnbull

The focus of the paper is the appropriateness of pragmatic elicitation techniques for generating talk to be used in analyses of talk and social structure. In the best pragmatic elicitation techniques (i) data are generated in situations in which researchers can manipulate variables in the testing of hypotheses, and (ii) speakers can talk freely and spontaneously without awareness that their talk is the object of study. This claim was tested in an examination of the hypothesis that more facework will occur in refusals to a High versus Low status requester. Requester status was manipulated in Oral and Written Discourse Completion, Role Play, and an Experimental elicitation technique. Support for the hypothesis was found only in the Role Play and Experimental conditions. Next, refusals generated in the above four elicitation conditions were compared to Naturally-occurring refusals. At the levels of the acts by which refusals are accomplished and the internal structure of the head act, Oral and Written DC produced anomalous and non-representative refusals. Role Play and the Experimental technique produced refusals that were very similar to Natural refusals, though Role Play refusals tended to be somewhat repetitive and long-winded. It is concluded that an Experimental technique is the preferred pragmatic elicitation technique.


2020 ◽  
Author(s):  
Catho Jacobs ◽  
Dorien Van De Mieroop ◽  
Colette Van Laar

Abstract We present a case study of a small talk sequence in a Belgian workplace between two female colleagues with a migration background, in which they share stories with each other on racial micro-aggressions they personally experienced. We draw on the social practice approach and focus on the narrators’ identity work in this interaction. We found that the narrators construct stories in which powerless and outgroup identities are projected upon them in the storyworld, but by means of which more empowered identities and an ingroup with the interlocutor are talked into being in the storytelling world. Interestingly, these findings can be linked to the rejection-identification dynamic. This social psychological model shows that individuals who experienced discrimination are able to buffer negative consequences to their psychological well-being by identifying with the group that is discriminated against. This article adds to this earlier research by showing the crucial role of language, in particular of storytelling and small talk, in this rejection-identification dynamic.


Author(s):  
Irina D. Boulyubash ◽  
O. S Bashta

The paper presents information concerning the relations between the subjective evaluation of social skills, parameters of the social network and the factors determining psychological well-being ofpatients with spinal cord injury sequellae (SCIS). Thus, one of the focuses of the diagnostic and therapeutic work of a clinical psychologist and psychotherapist in the rehabilitation hospital environment becomes as well a subjective assessment by SCIS patients of their own social skills, as the development of these skills, contributing to the expansion of the social network, which is a resource for the provision ofpsychological wellbeing ofpatients. This testifies not only to the need for correction of the emotional state ofpatients, but also the necessity of specific psychotherapeutic interventions. Such interventions should be aimed at the increasing in the level of communication skills which are useful for the formation of new social relationships and the development of the social network of patients (group forms of training, support groups, chat forums, etc.).


Author(s):  
Tim Harries

People not only want to be safe from natural hazards; they also want to feel they are safe. Sometimes these two desires pull in different directions, and when they do, this slows the journey to greater physical adaptation and resilience. All people want to feel safe—especially in their own homes. In fact, although not always a place of actual safety, in many cultures “home” is nonetheless idealized as a place of security and repose. The feeling of having a safe home is one part of what is termed ontological security: freedom from existential doubts and the ability to believe that life will continue in much the same way as it always has, without threat to familiar assumptions about time, space, identity, and well-being. By threatening our homes, floods, earthquakes, and similar events disrupt ontological security: they destroy the possessions that support our sense of who we are; they fracture the social structures that provide us with everyday needs such as friendship, play, and affection; they disrupt the routines that give our lives a sense of predictability; and they challenge the myth of our immortality. Such events, therefore, not only cause physical injury and loss; by damaging ontological security, they also cause emotional distress and jeopardize long-term mental health. However, ontological security is undermined not only by the occurrence of hazard events but also by their anticipation. This affects people’s willingness to take steps that would reduce hazard vulnerability. Those who are confident that they can eliminate their exposure to a hazard will usually do so. More commonly, however, the available options come with uncertainty and social/psychological risks: often, the available options only reduce vulnerability, and sometimes people doubt the effectiveness of these options or their ability to choose and implement appropriate measures. In these circumstances, the risk to ontological security that is implied by action can have greater influence than the potential benefits. For example, although installing a floodgate might reduce a business’s flood vulnerability, the business owner might feel that its presence would act as an everyday reminder that the business, and the income derived from it, are not secure. Similarly, bolting furniture to the walls of a home might reduce injuries in the next earthquake, but householders might also anticipate that it would remind them that there is a continual threat to their home. Both of these circumstances describe situations in which the anticipation of future feelings can tap into less conscious anxieties about ontological security. The manner in which people anticipate impacts on ontological security has several implications for preparedness. For example, it suggests that hazard warnings will be counterproductive if they are not accompanied by suggestions of easy, reliable ways of eliminating risk. It also suggests that adaptation measures should be designed not to enhance awareness of the hazard.


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