Bariatric Surgery Is a Safe and Effective Option for Patients with Inflammatory Bowel Diseases: A Case Series and Systematic Review of the Literature

Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.

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Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature

Seminars in Arthritis and Rheumatism ◽

10.1016/j.semarthrit.2015.07.006 ◽

2016 ◽

Vol 45 (4) ◽

pp. 475-482 ◽

Cited By ~ 54

Author(s):

Alice Sy ◽

Nader Khalidi ◽

Natasha Dehghan ◽

Lillian Barra ◽

Simon Carette ◽

...

Keyword(s):

Systematic Review ◽

Inflammatory Bowel Diseases ◽

Review Of The Literature ◽

Bowel Diseases ◽

Inflammatory Bowel

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Recurrent myocarditis in a patient with active ulcerative colitis: a case report and review of the literature

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2020-000587 ◽

2021 ◽

Vol 8 (1) ◽

pp. e000587

Author(s):

Giacomo Caio ◽

Lisa Lungaro ◽

Fabio Caputo ◽

Maria Muccinelli ◽

Maria Caterina Marcello ◽

...

Keyword(s):

Ulcerative Colitis ◽

Case Report ◽

Inflammatory Bowel Diseases ◽

Drug Toxicity ◽

Active Ulcerative Colitis ◽

Extraintestinal Manifestations ◽

Review Of The Literature ◽

Extraintestinal Manifestation ◽

Bowel Diseases ◽

Inflammatory Bowel

Inflammatory bowel diseases such as ulcerative colitis (UC) may be complicated by several extraintestinal manifestations. These involve joints, skin, eyes and less commonly lungs and heart. Myocarditis may result from the toxic effect of drugs (ie, mesalazine) commonly used for the treatment of UC or due to infections (eg, Coxsackieviruses, enteroviruses, adenovirus). Here, we report a case of a 26-year old man affected by UC and complicated by two episodes of myocarditis. Both episodes occurred during two severe exacerbations of UC. However, in both cases the aetiology of myocarditis remains uncertain being ascribable to extraintestinal manifestation, drug toxicity or both.

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