scholarly journals Factors Influencing the Onset of Neoadjuvant Therapy in Breast Cancer Patients

Breast Care ◽  
2019 ◽  
Vol 15 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Carolin Müller ◽  
Stephanie Juhasz-Böss ◽  
Gilda Schmidt ◽  
Erich-Franz Solomayer ◽  
Ingolf Juhasz-Böss ◽  
...  

Background: Time to treatment onset (TTTO) is critical in breast cancer patients receiving neoadjuvant chemotherapy (NACT). We therefore investigated possible delaying factors of therapy onset. Methods: All patients were included who qualified for NACT in our hospital from 2015 to 2017. The time interval between core biopsy of tumor and date of therapy onset was defined as primary endpoint. Among other things, age, out- and in-patient presentation, and study or standard treatment were investigated as potentially delaying factors. Results: We analyzed 139 patients scheduled for NACT; 90 (64.7%) received standard NACT, and 49 (35.3%) were recruited for trials. The average age was 53 years (±13.2 years). A time interval of 30.7 days (±11.8 days) was seen between diagnosis and therapy onset. Patients had a mean of 5 (±1.9) pretherapeutic presentations, 4 (±1.8) on outpatient and 1 (±0.5) on inpatient basis, being of significant influence on TTTO. Conclusion: Any outpatient presentation extended the time interval by 2 days, inpatient presentation by 4 days. These presentations should be merged in order to minimize TTTO. Neither the site of pathology examinations, additional consultations (genetics, reproductive medicine), nor study participation delayed therapy onset.

2014 ◽  
Vol 25 ◽  
pp. iv487
Author(s):  
L. Stamatovic ◽  
S.D. Mamula Masic ◽  
D. Vukotic ◽  
Z. Kovac ◽  
Z. Mihailovic ◽  
...  

2020 ◽  
Vol 138 ◽  
pp. S109
Author(s):  
M. Bortolini ◽  
L. Idda ◽  
D. Bono ◽  
E. Trino ◽  
R. Ragona ◽  
...  

1987 ◽  
Vol 5 (1) ◽  
pp. 68-74 ◽  
Author(s):  
W H Wolberg ◽  
M A Tanner ◽  
E P Romsaas ◽  
D L Trump ◽  
J F Malec

Primary breast cancer treatment is determined by tumor factors and by patient preference. Breast cancer treatments that preserve the cosmetic appearance of the breast are appealing and effective for appropriately selected patients; long-term survival following tumor excision and breast irradiation appears to be comparable to that for mastectomy. Since April 1981, when a protocol was developed and treatment options were offered, factors influencing treatment selection have been analyzed in 206 consecutive primary breast cancer patients. Mastectomy was dictated by tumor-related factors in 96 patients (47%); 110 patients (53%) had the option of mastectomy or conservation--tumor excision plus radiotherapy to the breast. Among these 110 eligible patients, 54 chose conservation (49%) and 56 chose mastectomy (51%). Intraoperative findings for ten patients electing conservation necessitated mastectomy, so conservation was accomplished for 44 (21%) of those treated for breast cancer. Beginning in July 1982, breast cancer patients took a battery of psychosexual assessments before any operation (Profile of Mood States [POMS], Health Locus of Control Scale [HLCS] Locke-Wallace Marital Adjustment Test [MAT], Psychosocial Adjustment to Illness Scale [PAIS], Derogatis Sexual Function Inventory [DSFI], Millon Clinical Multiaxial Inventory [MCMI], and a Breast Cancer Information Test [BCIT]). Comparisons of psychologic and demographic variables were made between patients who chose mastectomy and those who chose conservation. No demographic variable was statistically significantly related to choice, although older women tended to select mastectomy more than younger women. Compared with those who elected conservation, women who elected mastectomy were more tense and anxious (P less than .01), more introverted (P less than .01), felt more depressed and dejected (P less than .05), and reported more sexual problems (P less than .05). Those who elected conservation valued their physical appearance more highly (P less than .01) and were generally more self-interested (P less than .05). Mastectomy was dictated by medical considerations for approximately half of patients with breast cancer. Among candidates for breast conservation, the importance of retaining the breast appeared to be determined to a significant degree by measurable psychological factors.


2019 ◽  
Vol 18 (2) ◽  
pp. 82-88
Author(s):  
Safa Najafi ◽  
Masoud Sadeghi ◽  
Fereshteh Abasvandi ◽  
Mohammad Reza Shajari ◽  
Kamran Mohebi ◽  
...  

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 607-607
Author(s):  
K. Hisamatsu ◽  
W. Takiyama ◽  
R. Sakabe ◽  
Y. Satou ◽  
S. Saiki ◽  
...  

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