Distinct Association of Serum Vitamin D Concentration with Disease Activity and Trough Levels of Infliximab and Adalimumab during Inflammatory Bowel Disease Treatment

Background: Studies of serum vitamin D (Vit-D) levels in patients with inflammatory bowel disease (IBD) treated with anti-tumor necrosis factor-alpha (anti-TNF-α) agents are scarce. The conjunction of Vit-D as well as zinc levels and anti-TNF-α-trough concentrations (TC) has not yet been explored. Objectives: To determine the association of serum Vit-D, zinc and C-reactive protein (CRP) levels with clinical and biochemical remission and a possible correlation with serum TC and antibody levels of anti-TNF-α. Methods: Serum Vit-D and zinc levels as well as Infliximab (IFX) and Adalimumab (ADA) TC during the maintenance phase of treatment were measured in 112 IBD patients. Statistical analysis were performed for clinical and biochemical remission. Results: Vit-D and zinc deficiency were detected in 58 and 4.5% of the patients respectively. In IFX-treated patients, IFX-TC, Vit-D and CRP levels were associated independently with clinical remission with an OR of 20 (95% CI 1.3–333, p = 0.03), 1.3 (95% CI 1.1–1.7, p = 0.02) and 0.4 (95% CI 0.2–0.8, p = 0.01) respectively. Serum IFX-TC and Vit-D levels correlated positively (r = 0.39, p = 0.001), while serum IFX-TC and CRP levels showed an inverse correlation (r = –0.43, p < 0.001). Only IFX-TC associated independently with biochemical remission with a threshold of 3.1 µg/mL. In ADA-treated patients, ADA-TC associated independently with clinical and biochemical remission with an OR of 2.5 (95% CI 1.1–5.0, p = 0.04) and 1.3 (95% CI 1.1–1.4, p = 0.03) respectively. The serum zinc level was associated neither with clinical nor with biochemical remission in either cohort. Conclusions: Our results indicate that serum Vit-D level may be a predictive marker in addition to drug trough levels in IBD patients treated with IFX. Furthermore, due to the correlation between serum IFX and Vit-D levels, Vit-D substitution should be conducted in patients with low Vit-D levels.

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Serum vitamin D but not zinc levels are associated with different disease activity status in patients with inflammatory bowel disease

Medicine ◽

10.1097/md.0000000000015172 ◽

2019 ◽

Vol 98 (15) ◽

pp. e15172 ◽

Cited By ~ 9

Author(s):

Nicolae-Catalin Mechie ◽

Eirini Mavropoulou ◽

Volker Ellenrieder ◽

Golo Petzold ◽

Steffen Kunsch ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Vitamin D ◽

Disease Activity ◽

Bowel Disease ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Inflammatory Bowel ◽

Zinc Levels

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S2003 Serum Vitamin D Level and Disease Activity in Pediatric Inflammatory Bowel Disease

Gastroenterology ◽

10.1016/s0016-5085(10)61374-1 ◽

2010 ◽

Vol 138 (5) ◽

pp. S-299

Author(s):

Adam Safdi ◽

Sharon D'Mello ◽

Thomas D. Walters ◽

Anne M. Griffiths ◽

Lee Denson

Keyword(s):

Inflammatory Bowel Disease ◽

Vitamin D ◽

Disease Activity ◽

Bowel Disease ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Pediatric Inflammatory Bowel Disease ◽

Inflammatory Bowel

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VITAMIN D DEFICIENCY AMONG INFLAMMATORYBOWEL DISEASE PATIENTS IN ARGENTINA: A CROSS-SECTIONAL STUDY

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201800000-57 ◽

2018 ◽

Vol 55 (3) ◽

pp. 216-220 ◽

Cited By ~ 1

Author(s):

María Constanza TORELLA ◽

Astrid RAUSCH ◽

Juan LASA ◽

Ignacio ZUBIAURRE

Keyword(s):

Inflammatory Bowel Disease ◽

Vitamin D ◽

Hospital Admission ◽

Vitamin D Deficiency ◽

Bowel Disease ◽

Disease Duration ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Inflammatory Bowel

ABSTRACT BACKGROUND: An association has been established between low serum values of vitamin D and inflammatory bowel disease. There is a lack of evidence on whether this association is still observed in regions where sun exposure throughout the year is higher. OBJECTIVE: To compare the prevalence of vitamin D deficiency between inflammatory bowel disease patients and healthy controls. METHODS: Inflammatory bowel disease patients were consecutively enrolled as cases. Age and gender-matched healthy subjects who agreed to undertake a determination of serum vitamin D were enrolled as controls. Demographic features, medical treatment, need for hospital admission at diagnosis, steroid treatment, smoking, need for surgical treatment were evaluated as factors associated with vitamin D deficiency. RESULTS: Overall, 59 patients with a diagnosis of either Crohn’s disease or ulcerative colitis were enrolled, as well as 56 controls. Median age was 41 years (19-79) and 56% were male. Vitamin D deficiency was observed in 66.1% of inflammatory bowel disease patients versus 21.42% of healthy controls (OR 7.15 (3.1-16.48), P=0.001). Among inflammatory bowel disease patients, male gender, disease duration, moderate-to-severe disease and hospital admission at the moment of diagnosis were found to be associated with vitamin D deficiency. On multivariate analysis, only longer disease duration [(OR 1.01 (1-1.06)] and hospital admission at diagnosis [(OR 5.63 (1.01-31.61)] were found to be significantly associated with the latter. CONCLUSION: Vitamin D deficiency was more frequent among inflammatory bowel disease patients. Longer disease duration and need for hospital admission at diagnosis were associated to vitamin D deficiency among these patients.

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