scholarly journals State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models

2020 ◽  
Vol 33 (4) ◽  
pp. 213-230
Author(s):  
Thomas Schmitt ◽  
Reinhard H.H. Neubert
Keyword(s):  
Stratum Corneum ◽  
Matrix Models ◽  
State Of The Art ◽  
Lipid Matrix ◽  
Stratum Corneum Lipid

scholarly journals Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models

Langmuir ◽  
2020 ◽  
Vol 36 (34) ◽  
pp. 10270-10278
Author(s):  
Charlotte M. Beddoes ◽  
Gert S. Gooris ◽  
Fabrizia Foglia ◽  
Delaram Ahmadi ◽  
David J. Barlow ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Matrix Models ◽  
Lipid Matrix ◽  
Stratum Corneum Lipid

scholarly journals Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Tineke Berkers ◽  
Dani Visscher ◽  
Gert S. Gooris ◽  
Joke A. Bouwstra
Keyword(s):  
Stratum Corneum ◽  
Ex Vivo ◽  
Lipid Matrix ◽  
Stratum Corneum Lipid

scholarly journals Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase

2016 ◽  
Vol 1858 (8) ◽  
pp. 1926-1934 ◽  
Author(s):  
E.H. Mojumdar ◽  
G.S. Gooris ◽  
D. Groen ◽  
D.J. Barlow ◽  
M.J. Lawrence ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Unit Cell ◽  
Lipid Matrix ◽  
Stratum Corneum Lipid

Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin

2016 ◽  
Vol 26 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Tineke Berkers ◽  
Lauri van Dijk ◽  
Samira Absalah ◽  
Jeroen van Smeden ◽  
Joke A. Bouwstra
Keyword(s):  
Fatty Acids ◽  
Stratum Corneum ◽  
Lipid Matrix ◽  
Stratum Corneum Lipid

scholarly journals The physics of stratum corneum lipid membranes

2016 ◽  
Vol 374 (2072) ◽  
pp. 20150126 ◽  
Author(s):  
Chinmay Das ◽  
Peter D. Olmsted
Keyword(s):  
Stratum Corneum ◽  
Lipid Bilayers ◽  
Lipid Membranes ◽  
Plasma Membranes ◽  
Lipid Matrix ◽  
Large Variability ◽  
Head Groups ◽  
Stratum Corneum Lipid ◽  
Main Barrier ◽  
Lipid Assemblies

The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.

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