scholarly journals Colonic Metastasis of Primary Lung Cancer

2021 ◽  
pp. 901-905
Author(s):  
Salman Idrees Bhutta ◽  
Yasar Ahmed ◽  
Talal Zahid ◽  
Habib ur Rehman ◽  
Mutaz M. Nur ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Colorectal Adenocarcinoma ◽  
Primary Lung Cancer ◽  
Secondary Site ◽  
Computed Tomography Scan ◽  
Colonic Metastasis ◽  
The Poor ◽  
Tumor Biopsies ◽  
Tomography Scan

The colon is an uncommon secondary site for metastasis of lung adenocarcinoma. Distinguishing primary colonic carcinoma from metastatic spread of lung carcinoma can be difficult. We present a case of a patient with lung adenocarcinoma who, on abdominal computed tomography scan examination, was found to have a sigmoid tumor that was thought to represent a synchronous primary colorectal adenocarcinoma. Histological examination of endoscopic sigmoid tumor biopsies confirmed this to be metastasis from the lung adenocarcinoma. The patient subsequently developed major rectal bleeding and deteriorated significantly. This case also illustrates the poor prognosis association with colorectal metastasis of lung cancer.

scholarly journals An elderly female patient with ROS1 rearrangement primary lung adenocarcinoma and breast carcinoma: a rare case report and review of the literature

2019 ◽  
Vol 2 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Xiaojuan Yang ◽  
Diyuan Qin ◽  
Yu Zhang ◽  
Xue Li ◽  
Ning Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Elderly Patients ◽  
Lung Adenocarcinoma ◽  
Female Patient ◽  
Malignant Tumors ◽  
Primary Lung Cancer ◽  
Lung Cancer Mortality ◽  
Anaplastic Lymphoma ◽  
Reduced Dose

Abstract We report the case of a 90-year-old female patient who was suffering from c-ros oncogene 1 (ros-1) rearrangement adenocarcinoma and breast cancer. After about 14 months of a reduced dose of crizotinib treatment, she had a stable disease according to the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1). This patient’s case demonstrates that ros-1 rearrangements are not limited to patients of young age. In addition, this case indicates that crizotinib, as second-line, or even first-line, treatment may be effective and manageable in elderly patients. Furthermore, for elderly patients carrying a ros1 fusion, a reduced dose of crizotinib may be efficacious rather than a resistance factor. Based on our findings, we recommend that elderly patients with advanced lung adenocarcinoma should be considered for inclusion in molecular screening for ros-1 translocation, especially for never-smokers negative for epidermal growth factor receptor (egfr) mutation and the fusion between echinoderm microtubule associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK). This deserves attention because the population is aging, with increasing incidence and morbidity of multiple primary malignant tumors. Neglect of breast nodules at the onset is one of the limitations of our case, as combination of primary lung cancer with breast cancer is common. Above all, use of antiestrogens before and after the diagnosis of non-small-cell lung cancer is related to a reduced risk of lung cancer mortality. Therefore, careful attention should always be paid to these cases.

scholarly journals Ileo-psoas muscle metastasis from pulmonary carcinoma

1970 ◽  
Vol 2 (3) ◽  
pp. 251-253 ◽  
Author(s):  
S Parajuli ◽  
RB Basnet ◽  
A Tuladhar
Keyword(s):  
Lung Cancer ◽  
Primary Lung Cancer ◽  
Psoas Muscle ◽  
Excisional Biopsy ◽  
Heavy Smoking ◽  
Pulmonary Carcinoma ◽  
Muscle Metastasis ◽  
Unusual Phenomenon ◽  
History Of ◽  
Tomography Scan

Metastatic disease to muscle is rare and may be misdiagnosed when it is the presenting symptom, particularly in the absence of a known primary tumor. Skeletal muscle metastasis as a mode of presentation of primary lung cancer is an unusual phenomenon. Here, we report a case of ileo-psoas muscle metastasis from lung cancer as the initial clinical manifestation in a 58 year-old male with a personal history of heavy smoking. Excisional biopsy of the mass in the ileo-psoas muscle revealed metastatic adenocarcinoma. Computed tomography scan of the chest for a primary search was done and found to be pulmonary carcinoma. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6033 JPN 2012; 2(3): 251-253

scholarly journals Detection of EGFR Mutation of Pulmonary Adenocarcinoma in Sputum using Droplet Digital PCR

2021 ◽  
Author(s):  
Tetsuya Isaka ◽  
Tomoyuki Yokose ◽  
Hiroyuki Ito ◽  
Haruhiko Nakayama ◽  
Yohei Miyagi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Tumor Size ◽  
Mutation Detection ◽  
Egfr Mutation ◽  
Lung Tumor ◽  
Primary Lung Cancer ◽  
Resected Specimen ◽  
Sputum Cytology ◽  
Primary Lung Adenocarcinoma

Abstract Background】It is still unclear whether epidermal growth factor receptor (EGFR) mutation of primary lung adenocarcinoma can be detected accurately on sputum samples. This study aimed to examine EGFR mutations of primary lung adenocarcinoma in sputum samples using droplet digital polymerase chain reaction (ddPCR) and compare it with an EGFR mutation in surgically resected lung cancer. 【Methods】Sputum was collected preoperatively from patients with primary lung cancer who were scheduled for complete resection of lung tumor at Kanagawa Cancer Center from September 2014 to May 2016. ddPCR was performed to detect EGFR exon 21 L858R point mutation (Ex21 mutation) and EGFR exon 19 deletion mutation (Ex19 mutation) in the sputum samples. The concordance of EGFR mutation status in sputum samples and tumors in surgically resected specimen was evaluated for each positive and negative cytology group.【Results】One hundred and eighteen patients with primary lung adenocarcinoma provided sputum samples. Sputum cytology was positive in 13 patients (11.0%). ddPCR detected two cases of Ex21 mutation and two cases of Ex19 mutation. Compared to surgically resected specimens, the sensitivity, specificity, and positive predictive value of EGFR mutation detection were 80.0%, 100%, and 92.3%, respectively. The sensitivity of EGFR mutation detection was 3.1% in sputum cytology negative cases. Logistic regression model analysis revealed that tumor size ≥ 29 mm determined using computed tomography (CT) was an independent potential predictive factor for positive sputum cytology (odds ratio = 10.6, 95% confidence interval: 1.85–61.0, p=0.008).【Conclusions】EGFR mutation of primary lung adenocarcinoma was accurately detected in sputum samples using ddPCR if the sputum cytology was positive. Sputum samples should be collected in patients with CT tumor size ≥ 29 mm for EGFR mutation analysis.

scholarly journals ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma

2020 ◽  
Vol 19 ◽  
pp. 153303382094601
Author(s):  
Hongmei Sun ◽  
Mingying Zhang ◽  
Li Li ◽  
Zongwen Huang
Keyword(s):  
Lung Cancer ◽  
Prognostic Factors ◽  
Propensity Score ◽  
Lung Adenocarcinoma ◽  
Propensity Score Matching ◽  
Aldehyde Dehydrogenase ◽  
Tumor Size ◽  
Poor Prognosis ◽  
Prognostic Biomarker ◽  
The Poor

Background: Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common type of lung cancer. Although emerging evidence implicates the role of several aldehyde dehydrogenases in cancer progression, the expression and clinical significance of aldehyde dehydrogenase 3B1 in lung adenocarcinoma has never been studied. Materials: In our study, the expression of aldehyde dehydrogenase 3B1 in 250 cases of lung adenocarcinoma was detected with immunohistochemistry, and the patients were further divided into subgroups with different aldehyde dehydrogenase 3B1 expression. Using real-time polymerase chain reaction, we investigated the aldehyde dehydrogenase 3B1 messenger RNA in 20 lung adenocarcinoma and paired normal lung tissues. With the χ2 test, we evaluated the clinical significance of aldehyde dehydrogenase 3B1 by analyzing its correlation with the clinicopathological factors. Propensity score matching was performed to balance the baseline of cohort. With univariate and multivariate analyses, we screened the prognostic factors of lung adenocarcinoma and identified the independent prognostic factors before and after the propensity score matching. Results: Aldehyde dehydrogenase 3B1 expression was significantly associated with the sex and age of patients, tumor size, and histological grade. High expression of aldehyde dehydrogenase 3B1 predicted the poor prognosis ( P = .003). Moreover, male patients ( P = .020), large tumor size ( P = .009), advanced T stage ( P = .001), positive lymphatic invasion ( P < .001), and advanced tumor–node–metastasis stage ( P < .001) were all the prognostic factors for unfavorable outcome. Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the poor prognosis. In addition, after balancing the baseline characteristics by propensity score matching, we also demonstrated that aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma ( P = .007). Conclusions: Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the unfavorable prognosis. Postoperative detection of aldehyde dehydrogenase 3B1 would help stratify the high-risk patients with lung adenocarcinoma and guide individual treatment.

scholarly journals False-Positive Elevation of CK-MB Levels with Chest Pain in Lung Adenocarcinoma

2020 ◽  
Vol 13 (1) ◽  
pp. 100-104
Author(s):  
Takayo Ota ◽  
Yoshikazu Hasegawa ◽  
Eriko Murata ◽  
Noriko Tanaka ◽  
Masahiro Fukuoka
Keyword(s):  
Chest Pain ◽  
Lung Adenocarcinoma ◽  
Cardiac Injury ◽  
Electrophoretic Analysis ◽  
Computed Tomography Scan ◽  
Laboratory Findings ◽  
Coronary Syndrome ◽  
Visceral Pleural Invasion ◽  
Tomography Scan

The creatinine kinase (CK)-MB assay can be used for the early diagnosis of acute coronary syndrome. We describe the case of an 82-year-old male with lung adenocarcinoma who presented with chest pain. While laboratory findings showed elevated CK-MB levels, there was no cardiac injury. A chest computed tomography scan revealed pleural carcinomatosis. Later, electrophoretic analysis of CK showed a normal CK-MB range but increased CK-BB levels and the presence of macro CK type 2. We determined that the patient’s chest pain originated from the visceral pleural invasion of lung cancer. Because of the methods used to measure the CK-MB isozyme, the CK-MB level appeared elevated.

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