Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report

Intrauterine exposure to baclofen can lead to syndrome of withdrawal during the first days of the newborn. We report the case of a full-term baby exposed to baclofen during pregnancy. The mother was treated with baclofen 10 mg 4 times daily. Blood samples were collected from the mother before entering labor and from the baby at H0, H11, H31, and H102 after birth to measure baclofen concentrations and monitor its elimination. Baclofen maternal and neonate pharmacokinetics (PK) and placental transfer were assessed using a physiologically based PK model. Baclofen PK in the neonate after birth followed a monoexponential elimination with a half-life of 10 h, 3-fold longer than that in adults. The newborn was monitored for 11 days without experiencing any symptoms of withdrawal. Reducing baclofen dosing regimen of the mother to the lowest and therefore reducing fetal exposure to baclofen is essential. This case reports for the first time the baclofen pharmacokinetic profile in a newborn.

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Dr. Vladislav Garaevich (from Krakow). A case of pregnancy and childbirth after undergoing surgery for extirpation of the right kidney. (Przeglad chirurgiczny, 1894, volume II, book 1)

Journal of obstetrics and women s diseases ◽

10.17816/jowd92193-194 ◽

2020 ◽

Vol 9 (2) ◽

pp. 193-194

Author(s):

B. Polonsky

Keyword(s):

Full Term ◽

Pregnancy And Childbirth ◽

Term Baby ◽

The Right ◽

First Time

A 24-year-old woman, always, from the first appearance of a regulation at the age of 16, suffered from dysmenorrhea. Menstrua are scanty, clotted. In July 87, she became pregnant in the first time. In April 88, she gave birth to a full-term baby. A few months after the birth, there were strong and frequent urges to urinate, pain in the right side and right thigh. In summer, in 1890, these phenomena increased significantly, the patient began to have a fever. The urine began to stand out dark red, cloudy.

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A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2021.108045 ◽

2021 ◽

pp. 108045

Author(s):

Matthijs W. van Hoogdalem ◽

Scott L. Wexelblatt ◽

Henry T. Akinbi ◽

Alexander A. Vinks ◽

Tomoyuki Mizuno

Keyword(s):

Withdrawal Syndrome ◽

Placental Transfer ◽

Opioid Withdrawal ◽

Pharmacokinetic Modeling ◽

Fetal Exposure ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Opioid Withdrawal Syndrome ◽

Induced Changes

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Evaluation of a Physiologically-Based Pharmacokinetic Approach for Simulating the First-Time-In-Animal Study

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/j.1742-7843.2005.pto960321.x ◽

2005 ◽

Vol 96 (3) ◽

pp. 254-256 ◽

Cited By ~ 8

Author(s):

Massimiliano Germani ◽

Patrizia Crivori ◽

Maurizio Rocchetti ◽

Philip S. Burton ◽

Alan G. E. Wilson ◽

...

Keyword(s):

Animal Study ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

First Time ◽

Pharmacokinetic Approach

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Guidance Level for Brevetoxins in French Shellfish

Marine Drugs ◽

10.3390/md19090520 ◽

2021 ◽

Vol 19 (9) ◽

pp. 520

Author(s):

Nathalie Arnich ◽

Eric Abadie ◽

Zouher Amzil ◽

Marie-Yasmine Dechraoui Bottein ◽

Katia Comte ◽

...

Keyword(s):

Working Group ◽

Case Reports ◽

Human Case ◽

Portion Size ◽

Shellfish Poisoning ◽

Marine Biotoxins ◽

Toxicological Data ◽

Set Up ◽

First Time ◽

Environmental And Occupational Health

Brevetoxins (BTXs) are marine biotoxins responsible for neurotoxic shellfish poisoning (NSP) after ingestion of contaminated shellfish. NSP is characterized by neurological, gastrointestinal and/or cardiovascular symptoms. The main known producer of BTXs is the dinoflagellate Karenia brevis, but other microalgae are also suspected to synthesize BTX-like compounds. BTXs are currently not regulated in France and in Europe. In November 2018, they have been detected for the first time in France in mussels from a lagoon in the Corsica Island (Mediterranean Sea), as part of the network for monitoring the emergence of marine biotoxins in shellfish. To prevent health risks associated with the consumption of shellfish contaminated with BTXs in France, a working group was set up by the French Agency for Food, Environmental and Occupational Health & Safety (Anses). One of the aims of this working group was to propose a guidance level for the presence of BTXs in shellfish. Toxicological data were too limited to derive an acute oral reference dose (ARfD). Based on human case reports, we identified two lowest-observed-adverse-effect levels (LOAELs). A guidance level of 180 µg BTX-3 eq./kg shellfish meat is proposed, considering a protective default portion size of 400 g shellfish meat.

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What are the characteristics of first time older sexual offenders?

International Psychogeriatrics ◽

10.1017/s1041610217002186 ◽

2017 ◽

Vol 30 (5) ◽

pp. 647-662 ◽

Cited By ~ 2

Author(s):

Joanne Chua ◽

Gary Cheung ◽

Susan Hatters Friedman ◽

Sigourney Taylor

Keyword(s):

Sex Offenders ◽

Sexual Offenders ◽

Selection Criteria ◽

Case Reports ◽

Neurocognitive Disorder ◽

Cognitive Assessments ◽

Research Papers ◽

The Past ◽

The Common ◽

First Time

ABSTRACTBackground:Our objective was to examine and describe the common socio-demographic and clinical characteristics of first time older sex offenders.Methods:Research papers published in MEDLINE, PsycINFO, and EMBASE were searched systematically. Following removal of duplicates and irrelevant papers, a total of 423 papers were reviewed to determine whether the selection criteria were met. A total of seven publications were included and evaluated by two researchers.Results:Of the seven publications, there were two retrospective research studies and five case reports. There was a higher proportion of neurocognitive disorder in this offender group and the victims were usually vulnerable individuals. Yet, cognitive assessments were rarely done or reported. Two subtypes of older sex offenders were identified: (i) offenders who had offended in the past but were not previously detected; (ii) first-time offenders with a high proportion of neurocognitive disorder.Conclusion:There is a paucity of research in first time sex offending by older people. This review has highlighted a need for better designed studies to explore the characteristics of older sex offenders. Better collaboration between forensic and old-age psychiatric services is required for improved assessment and management of older sex offenders.

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