scholarly journals The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials

2021 ◽  
pp. 1-9
Author(s):  
Jochen G. Raimann ◽  
Christopher T. Chan ◽  
John T. Daugirdas ◽  
Thomas Depner ◽  
Tom Greene ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Serum Sodium ◽  
Statistical Significance ◽  
Extracellular Fluid ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Left Ventricular ◽  
Daily Trial ◽  
Ventricular Mass ◽  
Frequent Hemodialysis

<b><i>Introduction:</i></b> The Frequent Hemodialysis Network (FHN) Daily and Nocturnal trials aimed to compare the effects of hemodialysis (HD) given 6 versus 3 times per week. More frequent in-center HD significantly reduced left-ventricular mass (LVM), with more pronounced effects in patients with low urine volumes. In this study, we aimed to explore another potential effect modifier: the predialysis serum sodium (SNa) and related proxies of plasma tonicity. <b><i>Methods:</i></b> Using data from the FHN Daily and Nocturnal Trials, we compared the effects of frequent HD on LVM among patients stratified by SNa, dialysate-to-predialysis serum-sodium gradient (GNa), systolic and diastolic blood pressure, time-integrated sodium-adjusted fluid load (TIFL), and extracellular fluid volume estimated by bioelectrical impedance analysis. <b><i>Results:</i></b> In 197 enrolled subjects in the FHN Daily Trial, the treatment effect of frequent HD on ∆LVM was modified by SNa. When the FHN Daily Trial participants are divided into lower and higher predialysis SNa groups (less and greater than 138 mEq/L), the LVM reduction in the lower group was substantially higher (−28.0 [95% CI −40.5 to −15.4] g) than in the higher predialysis SNa group (−2.0 [95% CI −15.5 to 11.5] g). Accounting for GNa, TIFL also showed more pronounced effects among patients with higher GNa or higher TIFL. Results in the Nocturnal Trial were similar in direction and magnitude but did not reach statistical significance. <b><i>Discussion/Conclusion:</i></b> In the FHN Daily Trial, the favorable effects of frequent HD on left-ventricular hypertrophy were more pronounced among patients with lower predialysis SNa and higher GNa and TIFL. Whether these metrics can be used to identify patients most likely to benefit from frequent HD or other dialytic or nondialytic interventions remains to be determined. Prospective, adequately powered studies studying the effect of GNa reduction on mortality and hospitalization are needed.

The Association of Peritoneal Transport Properties with 24-Hour Blood Pressure Levels in Capd Patients

2003 ◽  
Vol 23 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Zeki Tonbul ◽  
Lutfullah Altintepe ◽  
Çetin Sözlü ◽  
Mehdi Yeksan ◽  
Alaattin Yildiz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Transport Properties ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Statistical Significance ◽  
Tertiary Care ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Peritoneal Transport

← Objectives We aimed to investigate the effects of peritoneal transport characteristics on blood pressure (BP) parameters, measured by 24-hour ambulatory blood pressure monitoring (ABPM), and on the development of left ventricular hypertrophy (LVH) in continuous ambulatory peritoneal dialysis (CAPD) patients. ← Design Cross-sectional and prospective design. ← Setting Tertiary-care center. ← Patients 25 CAPD patients (11 male, 14 female; mean age 47 ± 14 years) were included. Mean time on CAPD was 22.9 ± 18 months and all patients had been dialyzed for more than 6 months. The patients were divided into high, high-average, low-average, and low transport groups according to peritoneal equilibration test results. ← Main Outcome Measures Daytime and nighttime systolic and diastolic BP and left ventricular mass index among the different peritoneal transport groups; changes in BP parameters before and after increase in ultrafiltration. ← Results On 24-hour ABPM records, 13 patients (52%) were found to be hypertensive. Both mean systolic and diastolic BP were significantly increased in high-transporter groups compared to low transporters in both daytime and nighttime BP parameters. Left ventricular mass index was higher in high transporters compared to low transporters, without reaching statistical significance: 160 ± 23 vs 119 ± 41 g/m2, p > 0.05. Following increase in ultrafiltration, mean systolic (145 ± 13 vs 128 ± 5 mmHg, p < 0.001) and diastolic (96 ± 10 vs 81 ± 3 mm Hg, p < 0.001) BP decreased, and BP levels returned to normotensive levels in 6 (46%) of the 13 hypertensive patients, requiring discontinuation of antihypertensive drugs. ← Conclusion Improvement in volume status resulted in a decrease in both daytime and nighttime BP. Differences in peritoneal transport properties were associated with the development of hypertension and LVH.

scholarly journals Correlation between echocardiographic left ventricular mass and atherogenic index of plasma in adult hypertensive subjects in Olabisi Onabanjo university teaching hospital, Sagamu

2020 ◽  
Vol 7 (10) ◽  
pp. 1460
Author(s):  
Olajide O. Oresegun ◽  
Okechuku S. Ogah ◽  
Oluranti B. Familoni ◽  
Akintunde Akinpelu
Keyword(s):  
Left Ventricular Mass ◽  
Statistical Significance ◽  
Elevated Serum ◽  
Left Ventricular ◽  
University Teaching ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
Positive Correlation ◽  
Ventricular Mass ◽  
The Difference

Background: Hypertension and dyslipidaemia are two major modifiable cardiovascular risk factors with their co-existence having more than an additive effect on endothelial function causing atherosclerosis. The purpose of this study was to determine the prevalence of dyslipidaemia in hypertensive subjects and to determine its relationship left ventricular hypertrophy.Methods: The study was a cross-sectional comparative one involving 120 hypertensive participants with LVH (subjects) and 60 age and sex-matched hypertensive participants without LVH (controls). Detailed history, physical examination, fasting lipid profile test, and echocardiogram were carried out on all participants.Results: The overall prevalence rate of dyslipidaemia in the study was 61.1%. The prevalence of dyslipidaemia in subjects (60.8%) was slightly lower than in controls (61.7%), though the difference was not statistically significant (p=0.914). The most common isolated lipid abnormality in the study was elevated serum LDL-C (55% in subjects, 46.7% in controls), though the difference did not achieve statistical significance (p= 0.370). The mean atherogenic index of plasma (AIP) was significantly higher in the subjects (0.34+0.23) than in the controls (0.22+0.28) (p=0.001). There was a positive correlation between echocardiographic left ventricular mass and AIP (r=0.298, p=0.001).Conclusion: There is a high prevalence of dyslipidaemia among hypertensive adults. There is also a positive correlation between echocardiographic left ventricular mass and AIP among adult hypertensive subjects.

The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials

2016 ◽  
Vol 41 (4) ◽  
pp. 277-286 ◽  
Author(s):  
Jochen G. Raimann ◽  
Christopher T. Chan ◽  
John T. Daugirdas ◽  
Tom Depner ◽  
Frank A. Gotch ◽  
...  
Keyword(s):  
Journal Club ◽  
Secondary Analysis ◽  
Urine Volume ◽  
Extracellular Fluid ◽  
Left Ventricular ◽  
Volume Control ◽  
Daily Trial ◽  
Interdialytic Weight Gain ◽  
Sodium Gradient ◽  
Frequent Hemodialysis

In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and a time-integrated estimate of ECF load (TIFL). We also explored whether volume and sodium loading contributed to the change in LVM over the study period. Treatment effects on volume parameters were analyzed for modification by UVol and the dialysate-to-serum sodium gradient. Predictors of change in LVM were determined using linear regression. Frequent HD reduced IDWG and TIFL in the Daily Trial. Among patients with UVol <100 ml/day, reduction in TIFL was associated with LVM reduction. This suggests that achievement of better volume control could attenuate changes in LVM associated with mortality and cardiovascular morbidity. TIFL may prove more useful than IDWG alone in guiding HD practice. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=441966.

Stentless vs. Stented Aortic Valve Replacement: Left Ventricular Mass Regression

2005 ◽  
Vol 13 (2) ◽  
pp. 112-118 ◽  
Author(s):  
Muhammed Tamim ◽  
Thierry Bové ◽  
Yves Van Belleghem ◽  
Katrien François ◽  
Yves Taeymans ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Left Ventricular Mass ◽  
Valve Replacement ◽  
Left Ventricular Mass Index ◽  
Statistical Significance ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Ventricular Mass

The aim of this retrospective study was to evaluate the time-related regression of left ventricular hypertrophy after stentless vs. stented aortic valve replacement. From January 1992 to December 2002, 145 patients had a Toronto stentless porcine valve and 106 had a stented Carpentier-Edwards aortic valve replacement. Over a 10-year follow-up, survival was superior in the Toronto group vs. the Carpentier-Edwards group (84% vs. 74% at 4 years; 78% vs. 68% at 6 years; p < 0.001). A significant and constant reduction of peak and mean transvalvular gradients after valve replacement resulted in substantial regression of left ventricular mass index in both groups, which did not reach statistical significance. However, this phenomenon stopped at 3 years, and left ventricular mass index increased slowly after 5 years. Stentless and stented bioprostheses both showed good early and late clinical and hemodynamic outcomes, with the advantage of better midterm survival for stentless xenografts.

Abstract #330: Insulin Resistance, Cardiac Output and Left Ventricular Mass in Different Degrees of Obesity

2006 ◽  
Vol 12 ◽  
pp. 6-7
Author(s):  
Juan Ybarra ◽  
Josep Maria Pou ◽  
Teresa Doñate ◽  
Monica Isart ◽  
Jaime Pujadas
Keyword(s):  
Insulin Resistance ◽  
Cardiac Output ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Ventricular Mass

The association of ankle brachial index with left ventricular hypertrophy and left ventricular mass index: the Dong-gu study

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 284-291 ◽  
Author(s):  
Seong-Woo Choi ◽  
Hye-Yeon Kim ◽  
Hye-Ran Ahn ◽  
Young-Hoon Lee ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Left Ventricular ◽  
Baseline Survey ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.

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