Correlation between echocardiographic left ventricular mass and atherogenic index of plasma in adult hypertensive subjects in Olabisi Onabanjo university teaching hospital, Sagamu

Background: Hypertension and dyslipidaemia are two major modifiable cardiovascular risk factors with their co-existence having more than an additive effect on endothelial function causing atherosclerosis. The purpose of this study was to determine the prevalence of dyslipidaemia in hypertensive subjects and to determine its relationship left ventricular hypertrophy.Methods: The study was a cross-sectional comparative one involving 120 hypertensive participants with LVH (subjects) and 60 age and sex-matched hypertensive participants without LVH (controls). Detailed history, physical examination, fasting lipid profile test, and echocardiogram were carried out on all participants.Results: The overall prevalence rate of dyslipidaemia in the study was 61.1%. The prevalence of dyslipidaemia in subjects (60.8%) was slightly lower than in controls (61.7%), though the difference was not statistically significant (p=0.914). The most common isolated lipid abnormality in the study was elevated serum LDL-C (55% in subjects, 46.7% in controls), though the difference did not achieve statistical significance (p= 0.370). The mean atherogenic index of plasma (AIP) was significantly higher in the subjects (0.34+0.23) than in the controls (0.22+0.28) (p=0.001). There was a positive correlation between echocardiographic left ventricular mass and AIP (r=0.298, p=0.001).Conclusion: There is a high prevalence of dyslipidaemia among hypertensive adults. There is also a positive correlation between echocardiographic left ventricular mass and AIP among adult hypertensive subjects.

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Correlation between echocardiographic left ventricular hypertrophy and microalbuminuria among hypertensive subjects in Olabisi Onabanjo university teaching hospital, Sagamu, Nigeria

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202591 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1141

Author(s):

Olajide O. Oresegun ◽

Oluranti B. Familoni ◽

Taiwo O. Olunuga ◽

Akintunde Akinpelu

Keyword(s):

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Urinary Albumin Excretion ◽

Left Ventricular ◽

Urinary Albumin ◽

University Teaching ◽

Positive Correlation ◽

Albumin Excretion ◽

Ventricular Mass

Background: Left ventricular hypertrophy is an adaptive response to volume and/or pressure overload, especially in hypertensive subjects. Microalbuminuria is a well-known predictor of poor cardiovascular outcomes in patients with hypertension. The purpose of this study was to determine the prevalence of microalbuminuria in hypertensive subjects and its relationship with LVH defined by echocardiogram in adult hypertensive subjects.Methods: The study was a cross-sectional comparative one involving 88 hypertensive volunteers with age and sex-matched normotensive controls. Detailed history, physical examination, urine assessment for microalbuminuria and echocardiogram were carried out on all participants.Results: The overall prevalence rate of microalbuminuria in the study was 29.5%. The prevalence of microalbuminuria in hypertensive subjects (43.2%) was significantly higher than in the normotensive counterparts (15.9%) (p=0.001). The prevalence of microalbuminuria in hypertensive subjects with echocardiographic LVH (81.0%) was significantly higher than in hypertensive participants without echocardiographic LVH (31.3%) (p=0.001). There was a positive correlation between left ventricular mass defined by echocardiogram and urinary albumin excretion in hypertensive subjects (r =0.422, p= 0.001).Conclusions: There is a high prevalence of microalbuminuria among hypertensive adults, especially those with left ventricular hypertrophy. There is also a positive correlation between echocardiographic left ventricular mass and urinary albumin excretion among adult hypertensive subjects.

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Assessment of the Difference of Left Ventricular Mass by Echocardiography between Korean and Whites

Korean Circulation Journal ◽

10.4070/kcj.1994.24.5.690 ◽

1994 ◽

Vol 24 (5) ◽

pp. 690

Author(s):

Young-Soo Lee ◽

Byung-Ok Kim ◽

Kun-Joo Rhee

Keyword(s):

Left Ventricular Mass ◽

Left Ventricular ◽

Ventricular Mass ◽

The Difference

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The Association of Peritoneal Transport Properties with 24-Hour Blood Pressure Levels in Capd Patients

Peritoneal Dialysis International ◽

10.1177/089686080302300106 ◽

2003 ◽

Vol 23 (1) ◽

pp. 46-52 ◽

Cited By ~ 23

Author(s):

Zeki Tonbul ◽

Lutfullah Altintepe ◽

Çetin Sözlü ◽

Mehdi Yeksan ◽

Alaattin Yildiz ◽

...

Keyword(s):

Blood Pressure ◽

Transport Properties ◽

Left Ventricular Mass ◽

Left Ventricular Mass Index ◽

Statistical Significance ◽

Tertiary Care ◽

Left Ventricular ◽

Ventricular Mass Index ◽

Ventricular Mass ◽

Peritoneal Transport

← Objectives We aimed to investigate the effects of peritoneal transport characteristics on blood pressure (BP) parameters, measured by 24-hour ambulatory blood pressure monitoring (ABPM), and on the development of left ventricular hypertrophy (LVH) in continuous ambulatory peritoneal dialysis (CAPD) patients. ← Design Cross-sectional and prospective design. ← Setting Tertiary-care center. ← Patients 25 CAPD patients (11 male, 14 female; mean age 47 ± 14 years) were included. Mean time on CAPD was 22.9 ± 18 months and all patients had been dialyzed for more than 6 months. The patients were divided into high, high-average, low-average, and low transport groups according to peritoneal equilibration test results. ← Main Outcome Measures Daytime and nighttime systolic and diastolic BP and left ventricular mass index among the different peritoneal transport groups; changes in BP parameters before and after increase in ultrafiltration. ← Results On 24-hour ABPM records, 13 patients (52%) were found to be hypertensive. Both mean systolic and diastolic BP were significantly increased in high-transporter groups compared to low transporters in both daytime and nighttime BP parameters. Left ventricular mass index was higher in high transporters compared to low transporters, without reaching statistical significance: 160 ± 23 vs 119 ± 41 g/m2, p > 0.05. Following increase in ultrafiltration, mean systolic (145 ± 13 vs 128 ± 5 mmHg, p < 0.001) and diastolic (96 ± 10 vs 81 ± 3 mm Hg, p < 0.001) BP decreased, and BP levels returned to normotensive levels in 6 (46%) of the 13 hypertensive patients, requiring discontinuation of antihypertensive drugs. ← Conclusion Improvement in volume status resulted in a decrease in both daytime and nighttime BP. Differences in peritoneal transport properties were associated with the development of hypertension and LVH.

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The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials

Kidney & Blood Pressure Research ◽

10.1159/000519339 ◽

2021 ◽

pp. 1-9

Author(s):

Jochen G. Raimann ◽

Christopher T. Chan ◽

John T. Daugirdas ◽

Thomas Depner ◽

Tom Greene ◽

...

Keyword(s):

Left Ventricular Mass ◽

Serum Sodium ◽

Statistical Significance ◽

Extracellular Fluid ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Left Ventricular ◽

Daily Trial ◽

Ventricular Mass ◽

Frequent Hemodialysis

Introduction: The Frequent Hemodialysis Network (FHN) Daily and Nocturnal trials aimed to compare the effects of hemodialysis (HD) given 6 versus 3 times per week. More frequent in-center HD significantly reduced left-ventricular mass (LVM), with more pronounced effects in patients with low urine volumes. In this study, we aimed to explore another potential effect modifier: the predialysis serum sodium (SNa) and related proxies of plasma tonicity. Methods: Using data from the FHN Daily and Nocturnal Trials, we compared the effects of frequent HD on LVM among patients stratified by SNa, dialysate-to-predialysis serum-sodium gradient (GNa), systolic and diastolic blood pressure, time-integrated sodium-adjusted fluid load (TIFL), and extracellular fluid volume estimated by bioelectrical impedance analysis. Results: In 197 enrolled subjects in the FHN Daily Trial, the treatment effect of frequent HD on ∆LVM was modified by SNa. When the FHN Daily Trial participants are divided into lower and higher predialysis SNa groups (less and greater than 138 mEq/L), the LVM reduction in the lower group was substantially higher (−28.0 [95% CI −40.5 to −15.4] g) than in the higher predialysis SNa group (−2.0 [95% CI −15.5 to 11.5] g). Accounting for GNa, TIFL also showed more pronounced effects among patients with higher GNa or higher TIFL. Results in the Nocturnal Trial were similar in direction and magnitude but did not reach statistical significance. Discussion/Conclusion: In the FHN Daily Trial, the favorable effects of frequent HD on left-ventricular hypertrophy were more pronounced among patients with lower predialysis SNa and higher GNa and TIFL. Whether these metrics can be used to identify patients most likely to benefit from frequent HD or other dialytic or nondialytic interventions remains to be determined. Prospective, adequately powered studies studying the effect of GNa reduction on mortality and hospitalization are needed.

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Indexation of left ventricular mass to body surface area and height to allometric power of 2.7: is the difference limited to obese hypertensives?

Journal of Human Hypertension ◽

10.1038/jhh.2009.16 ◽

2009 ◽

Vol 23 (11) ◽

pp. 728-734 ◽

Cited By ~ 45

Author(s):

C Cuspidi ◽

S Meani ◽

F Negri ◽

V Giudici ◽

C Valerio ◽

...

Keyword(s):

Surface Area ◽

Left Ventricular Mass ◽

Body Surface Area ◽

Body Surface ◽

Left Ventricular ◽

Ventricular Mass ◽

The Difference

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Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness

Journal of Cardiovascular Medicine ◽

10.2459/jcm.0000000000000549 ◽

2017 ◽

Vol 18 (12) ◽

pp. 954-961

Author(s):

Daisuke Kamimura ◽

Takeki Suzuki ◽

Anna L. Furniss ◽

Michael E. Griswold ◽

Iftikhar J. Kullo ◽

...

Keyword(s):

Left Ventricular Mass ◽

Left Ventricular Mass Index ◽

Elevated Serum ◽

Left Ventricular ◽

Myocardial Stiffness ◽

Ventricular Mass Index ◽

Ventricular Mass

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Abstract 1199: Low Serum Magnesium Concentrations Predict Increase in Left Ventricular Mass Over Five Years Independently of Common Cardiovascular Risk Factors: Study of Health in Pomerania

Circulation ◽

10.1161/circ.118.suppl_18.s_1084-a ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Thorsten Reffelmann ◽

Marcus Dörr ◽

Till Ittermann ◽

Henry Völzke ◽

Jörg Ruppert ◽

...

Keyword(s):

Left Ventricular Mass ◽

Antihypertensive Drugs ◽

Smoking Status ◽

Serum Magnesium ◽

Experimental Studies ◽

Population Based ◽

Left Ventricular ◽

Reactive Protein ◽

Ventricular Mass ◽

The Difference

Increased cardiac left ventricular mass (LVM) is a significant predictor of adverse cardiovascular events. Experimental studies suggest a pathophysiological role of magnesium (Mg ++ ) in the development of arterial hypertension and left ventricular hypertrophy (LVH). Subjects, aged 45 – 79 years, from the population-based, epidemiological, longitudinal “Study of Health in Pomerania” with complete echocardiographic data (n = 1 348 after exclusion of aortic valve disease) were grouped into five quintiles according to serum Mg ++ at baseline (0.790±0.003 mmol/l, mean±SEM). In the lowest Mg ++ -quintile (Mg ++ <<26>0.73 mmol/l), LVM (187.4±3.1 g at baseline) increased by 14.9±1.2 g over the following five years, while in the highest Mg ++ -quintile (Mg ++ <<0.85 mmol/l) LVM (186.7±3.4 g at baseline) decreased by −0.5±2.8 g (p<0.0001 between quintiles). After five years, LVM was significantly higher in the lowest Mg ++ -quintile (LVM: 202.2±3.4 g) in comparison to the highest Mg ++ -quintile (187.2±3.5 g, p<0.003 between quintiles). Mg ++ inversely correlated with the difference in LVM over five years (p<0.0001, females: p<0.002, males: p<0.024) and also with differences in Sokolow-Lyon-index over five years (p<0.01). Unlike age, gender, presence of hypertension or diabetes mellitus, body mass index, smoking status, renal function, high-sensitive C-reactive protein and use of various antihypertensive drugs including diuretics, only Mg ++ (p<0.0001), pulse pressure (p<0.002) and use of β-blockers (p<0.04) were identified as independent predictors of difference in LVM over five years. Hypomagnesemia is one of the strongest predictors of increase in LVM over the following five years. It should initiate decisive preventive measures in subjects prone to developing LVH.

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Stentless vs. Stented Aortic Valve Replacement: Left Ventricular Mass Regression

Asian Cardiovascular and Thoracic Annals ◽

10.1177/021849230501300204 ◽

2005 ◽

Vol 13 (2) ◽

pp. 112-118 ◽

Cited By ~ 8

Author(s):

Muhammed Tamim ◽

Thierry Bové ◽

Yves Van Belleghem ◽

Katrien François ◽

Yves Taeymans ◽

...

Keyword(s):

Aortic Valve ◽

Aortic Valve Replacement ◽

Left Ventricular Mass ◽

Valve Replacement ◽

Left Ventricular Mass Index ◽

Statistical Significance ◽

Left Ventricular ◽

Ventricular Mass Index ◽

Ventricular Mass

The aim of this retrospective study was to evaluate the time-related regression of left ventricular hypertrophy after stentless vs. stented aortic valve replacement. From January 1992 to December 2002, 145 patients had a Toronto stentless porcine valve and 106 had a stented Carpentier-Edwards aortic valve replacement. Over a 10-year follow-up, survival was superior in the Toronto group vs. the Carpentier-Edwards group (84% vs. 74% at 4 years; 78% vs. 68% at 6 years; p < 0.001). A significant and constant reduction of peak and mean transvalvular gradients after valve replacement resulted in substantial regression of left ventricular mass index in both groups, which did not reach statistical significance. However, this phenomenon stopped at 3 years, and left ventricular mass index increased slowly after 5 years. Stentless and stented bioprostheses both showed good early and late clinical and hemodynamic outcomes, with the advantage of better midterm survival for stentless xenografts.

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