scholarly journals Reduction in Tumor Lesions and Exacerbation of Psoriatic Rash after Septic Shock in a Patient with Extramammary Paget’s Disease

2021 ◽  
pp. 1591-1595
Author(s):  
Takehisa Nakanishi ◽  
Makoto Kondo ◽  
Yasuo Nakai ◽  
Koji Habe ◽  
Keiichi Yamanaka
Keyword(s):  
Septic Shock ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Nodule Volume ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Extramammary Paget's Disease

We present a case of extramammary Paget’s disease with bilateral inguinal lymph node metastasis treated by monthly docetaxel chemotherapy. He has also well-controlled psoriasis vulgaris for 20 years. One day after completing monthly chemotherapy, cellulitis by Group G <i>Streptococcus</i> occurred on both legs, resulting in septic shock and disseminated intravascular coagulation. During the infection, the tumor nodule volume and the exudate from the tumor decreased, and tumor markers carcinoembryonic antigen and cancer antigen 19-9 showed low values. Simultaneously, the psoriatic eruption reoccurred. We proposed that cytokine storm including tumor necrosis factor-alpha (TNF-α) during sepsis might have suppressed tumor lesions, and also TNF-α-dependent psoriatic rash appeared temporarily on his body.

scholarly journals Septic Shock after Seasonal Influenza Vaccination in an HIV-Infected Patient during Treatment with Etanercept for Rheumatoid Arthritis: a Case Report

2013 ◽  
Vol 20 (5) ◽  
pp. 761-764 ◽  
Author(s):  
Pasquale De Nardo ◽  
Rita Bellagamba ◽  
Angela Corpolongo ◽  
Elisa Gentilotti ◽  
Fabrizio Taglietti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Septic Shock ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Multiorgan Failure ◽  
Necrosis Factor Alpha ◽  
Infected Woman ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACTAnti-tumor necrosis factor alpha (anti-TNF-α) is used in the treatment of rheumatic diseases not responsive to first-line regimens. Data on the safety of anti-TNF-α in HIV-infected patients are scarce and conflicting. We describe a case of septic shock and multiorgan failure that occurred after etanercept initiation and influenza vaccination in an HIV-infected woman with rheumatoid arthritis.

Four cases of extramammary Paget's disease - A topographic study.

1984 ◽  
Vol 46 (5) ◽  
pp. 1118-1122 ◽  
Author(s):  
Yoshihisa FUJII ◽  
Nobuyuki SHIRAISHI ◽  
Etsuji MATSUNAGA ◽  
Susumu TAKAYASU ◽  
Toshitaka NAKAMURA
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

A Case of Extramammary Paget's Disease after Excision of Bilateral Breast Carcinoma

2007 ◽  
Vol 69 (3) ◽  
pp. 273-276
Author(s):  
Satoko KUMAZAWA ◽  
Kou DAN ◽  
Teiichi MASUDA ◽  
Kazunori URABE ◽  
Masutaka FURUE
Keyword(s):  
Breast Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Bilateral Breast Carcinoma ◽  
Extramammary Paget's Disease

Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease

2021 ◽  
Vol 41 (1) ◽  
pp. 219-226
Author(s):  
AYA KAWAGUCHI ◽  
JUN AKIBA ◽  
REIICHIRO KONDO ◽  
EIJI SADASHIMA ◽  
SACHIKO OGASAWARA ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Extramammary Paget's Disease

scholarly journals Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis.

2020 ◽  
Author(s):  
Wenna Gao ◽  
Ruilin Zhu ◽  
liu yang
Keyword(s):  
Diabetic Retinopathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Entire Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

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