scholarly journals ОСОБЛИВОСТІ РЕМОДЕЛЮВАННЯ СТРУКТУР СЛИЗОВОЇ ОБОЛОНКИ ШЛУНКА ПІСЛЯ РІЗНИХ МЕТОДІВ ХІРУРГІЧНОГО ЛІКУВАННЯ ВИРАЗКОВОЇ ХВОРОБИ ШЛУНКА У ВІДДАЛЕНОМУ ПЕРІОДІ

Author(s):  
А. Д. Беденюк

<p>A morphometric study of operated stomach walls after different methods of surgical treatment of gastric ulcer was performed. It was shown that in the remote period operated stomach wall structure had a tendency to regenerate. The most optimal changes were detected after organsparing method of surgical treatment – selective proximal vagotomy with sighting resection of ischemic segment of the stomach by L. Ya. Kovalchuk.</p>

1986 ◽  
Vol 67 (3) ◽  
pp. 164-166
Author(s):  
A. A. Chernyavsky ◽  
P. S. Zubeev ◽  
O. V. Milovidova ◽  
N. G. Mikhailova

Although conservative therapy remains the main treatment for duodenal ulcers, however, 20-30% of patients require surgical treatment. In recent years a new operative method - selective proximal vagotomy - has been introduced into the wide surgical practice of pyloroduodenal ulcers treatment. Its performance is connected with the decision on the surgeon's tactics concerning the ulcerous niche: should it be excised or left?


1966 ◽  
Vol 46 (2) ◽  
pp. 319-327 ◽  
Author(s):  
Marshall K. Bartlett

2021 ◽  
pp. 15-29
Author(s):  
V.V. Skyba ◽  
◽  
V.F. Rybalchenko ◽  
A.V. Ivanko ◽  
R.М. Borys ◽  
...  

Purpose – to improve the results of surgical treatment of patients with intra-abdominal infiltrates and abscesses through the introduction of the latest imaging methods and surgical technologies. Materials and methods. In the clinic of the Department of Surgical Diseases No 1, on the basis of the Surgery Center of the Kyiv City Clinical Hospital No. 1 from 2006 to 2019 218 patients with primary and secondary intra-abdominal infiltrates, abscesses and fluid formations were treated. The patients’ age ranged from 16 to 85 years. There were 107 (49.08%) male patients, 111 (50.92%) female patients. Depending on the time of hospitalization (by years), the patients were divided into two groups: the control group (CG) (2006–2012) 117 (53.67%) patients and the study group (SG) (2013–2019) 101 (46.33%) patients. The SG used the latest imaging technologies and improved methods of surgical treatment. Results. The patients were divided into two groups: primary in 191 (87.61%) and secondary postoperative infiltrates and abscesses in 27 (12.39%). The causes of primary infiltrates and abscesses were: complicated forms of appendicitis in 74 (33.94%), perforated stomach and duodenal ulcer in 48 (22.02%), complicated forms of cholecystitis in 69 (31.65%). Postoperative infiltrates and abscesses were observed in 27 (12.39%) patients who underwent urgent surgery: adgeolysis of adhesive ileus in 14 (6.42%) and complicated hernias of various localization in 13 (5.97%). Postoperative complications were diagnosed in 43 (19.72%) patients, of whom 34 (15.59%) from the surgical wound and 29 (15.18%) of the abdominal cavity, who required relaparotomy or laparoscopy, with destructive appendicitis in 10 (13.51%), perforated gastric ulcer and 12 duodenal ulcer in 6 (12.5%), destructive cholecystitis in 9 (13.04%), adhesive intestinal obstruction in 13 (19.12%) and with strangulated and complicated hernias in 14 (17.28%) of the examined patients. During relaparotomy, incompetence of the intestinal wall and intestinal sutures was established in 11 out of 32 patients, an ileostomy was imposed in 7, and cecostomy in 1 patient. Actually, in the control group, 8 (6.84%) patients died on the background of ongoing peritonitis, thrombosis of mesenteric vessels and multiple organ failure and concomitant ailments and in the study group 4 (3.96%) patients died. Conclusions. Surgical treatment is individualized depending on the disease, so with destructive appendicitis from 74 (38.74%) laparotomic in 42 (21.99%), laparoscopic in 32 (16.75%), and in 12 (6.28%) with conversion; perforated gastric ulcer and duodenal ulcer in 48 (25.13%) open laparotomy; with cholecystitis of 69 (36.13%) patients, 48 (25.13%) had laparotomy and 21 (11.00%) had laparoscopic examination. The use of the latest imaging and treatment technologies: Doppler ultrasonography, hydrojet scalpel and laparoscopy in 64 (33.51%), allowed to have better near and long-term results and to reduce postoperative mortality from 6.84% to 3.96%, with an average of 5.5%. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. The authors declare no conflicts of interests. Key words: destructive appendicitis, cholecystitis, perforated gastric ulcer and 12-duodenal ulcer, adhesive leakage, strangulated hernias, diagnosis and treatment.


BMJ ◽  
1903 ◽  
Vol 1 (2208) ◽  
pp. 953-955
Author(s):  
C. M. Moullin

1906 ◽  
Vol 44 (6) ◽  
pp. 907-916
Author(s):  
ROBERT G. LE CONTE

Author(s):  
О.В. Казаков ◽  
А.Ф. Повещенко ◽  
А.В. Кабаков ◽  
О.В. Повещенко ◽  
Д.Н. Стрункин ◽  
...  

Цель исследования - выявление структурных преобразований тимуса самок крыс Вистар при хирургическом лечении рака молочной железы и при химиотерапии. Методика. Рак молочной железы (РМЖ) индуцировали введением N-метил-N-нитрозомочевины 5 раз с интервалом 7 сут подкожно в область 2-й молочной железы справа. Оперативное лечение РМЖ проводили через 6 мес от момента индукции РМЖ. Курс химиотерапии проводили по схеме CMF. Гистологическое исследование тимуса и опухоли молочной железы проводили по стандартной методике. Методом точечного счёта производили морфометрию срезов и подсчет клеточных элементов в опухоли и структурно-функциональных зонах тимуса. Результаты. При РМЖ без лечения выявлены структурные признаки акцидентальной инволюции тимуса. После оперативного лечения РМЖ акцидентальная инволюция тимуса менее выражена по сравнению с химиотерапией. После оперативного лечения РМЖ, как и в группе РМЖ без лечения, в тимусе сохраняется уменьшение площади коркового вещества. По сравнению с РМЖ без лечения в тимусе уменьшалась площадь железистых эпителиальных образований, увеличилась плотность расположения клеточных элементов в корковом веществе. В структурных зонах тимуса увеличивалось количество макрофагов, снижалось количество клеток с пикнотичными ядрами. После химиотерапии, по сравнению с резекцией опухоли МЖ, в тимусе выявлены структурные признаки прогрессирования процесса инволюции. В тимусе уменьшена площадь соединительно-тканных элементов, снижено количество митозов в субкапсулярной зоне коркового вещества. Во всех исследуемых зонах увеличено количество клеток с пикнотичными ядрами и уменьшено число макрофагов. Заключение. После оперативного лечения РМЖ акцидентальная инволюция тимуса проявляется в менее выраженной форме, чем в группе с РМЖ без лечения. После химиотерапии РМЖ, по сравнению с оперативным лечением РМЖ, морфологические перестройки в тимусе свидетельствуют о снижении активности лимфоидного и эпителиального компонентов и увеличении числа гибнущих клеток. Aim. To identify structural changes in the thymus of female Wistar rats during surgical treatment of breast cancer or with chemotherapy. Methods. Breast cancer (BC) was induced by subcutaneous injection of N-methyl-N-nitrosourea into the second right breast 5 times at 7 day intervals. Resection of BC was performed 6 mos after BC induction, or chemotherapy was administered according to the CMF scheme. Histological examination of the thymus and breast tumor was performed according to a standard method. Morphometric study of sections and counting cell elements in the tumor and in structural and functional areas of the thymus were performed by point counting. Results. In untreated BC, structural signs of accidental thymus involution were evident. There was an increase in the area of connective tissue elements and of glandular epithelial tumors. After surgical treatment of BC, accidental thymus involution was less pronounced than after chemotherapy. Also after surgical treatment, as in the case of untreated BC, the thymus cortical substance remained decreased. Compared with untreated BC, the area of glandular epithelial tumors in the thymus decreased, and the density of cellular elements in the cortical substance increased. In the structural zones of the thymus, the number of macrophages increased, and the number of cells with pyknotic nuclei decreased. After chemotherapy, in comparison with surgical treatment, structural signs of involution of the thymus were evident. In the thymus, the area of connective tissue elements was reduced, and the number of mitotically dividing cells in the subcapsular zone of the cortical substance was reduced. In all the zones of the thymus, the number of cells with pyknotic nuclei increased, and the number of macrophages decreased. Conclusion. After surgical treatment of BC, accidental thymus involution was less pronounced than in the untreated group. After chemotherapy, compared with surgical treatment of BC, morphological changes in the thymus may indicate a decrease in the activity of the lymphoid and epithelial components and an increase in the number of dying cells.


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