The transrectal ultrasound/MRI fusion biopsy for prostate cancer diagnosis after previous negative biopsy: a case report

Introduction: The adoption of multiparametric MRI (mpMRI) guided fusion biopsy is becoming an important tool to improve the diagnostic yield in those suspected of having prostate cancer, especially for patients with suspicious lesion located at the anterior region that is uncommonly sampled at randomized biopsy. Methods: Herein we report a case of a man with persistent elevated PSA and a previous negative randomized prostate biopsy. His PSA was 8.1 ng/dL and a multiparametric MRI showed a 2cm suspicious PIRADS-4 lesion located at the anterior region of the right transition zone at base and mid gland. A transrectal ultrasound/MRI (TRUS/mpMRI) fusion biopsy was performed and its pathologic report showed a Gleason 3+4 (ISUP II) that was present only in the fragments that sampled the suspected area at MRI. We review the role of mpMRI in the diagnosis of prostate cancer at rebiopsy.

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Multiparametric MRI-Targeted TRUS Prostate Biopsies Using Visual Registration

BioMed Research International ◽

10.1155/2014/819360 ◽

2014 ◽

Vol 2014 ◽

pp. 1-11 ◽

Cited By ~ 24

Author(s):

Philippe Puech ◽

Adil Ouzzane ◽

Vianney Gaillard ◽

Nacim Betrouni ◽

Benoit Renard ◽

...

Keyword(s):

Prostate Cancer ◽

Diagnostic Yield ◽

Transrectal Ultrasound ◽

Multiparametric Mri ◽

Ultrasound Guided ◽

Prostate Biopsies ◽

Multiparametric Prostate Mri ◽

Clinically Significant ◽

Prostate Cancers ◽

Targeted Biopsies

Prebiopsy multiparametric prostate MRI (mp-MRI), followed by transrectal ultrasound-guided (TRUS-G) target biopsies (TB) of the prostate is a key combination for the diagnosis of clinically significant prostate cancers (CSPCa), to avoid prostate cancer (PCa) overtreatment. Several techniques are available for guiding TB to the suspicious mp-MRI targets, but the simplest, cheapest, and easiest to learn is “cognitive,” with visual registration of MRI and TRUS data. This review details the successive steps of the method (target detection, mp-MRI reporting, intermodality fusion, TRUS guidance to target, sampling simulation, sampling, TRUS session reporting, and quality insurance), how to optimize each, and the global indications of mp-MRI-targeted biopsies. We discuss the diagnostic yield of visually-registered TB in comparison with conventional biopsy, and TB performed using other registration methods.

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Improvement of prostate cancer detection rate using transrectal ultrasound-MRI targeted biopsy: The role of a CAD system combined to multiparametric MRI

European Urology Supplements ◽

10.1016/s1569-9056(18)32295-4 ◽

2018 ◽

Vol 17 (2) ◽

pp. e1881-e1882

Author(s):

M. Pecoraro ◽

R. Campa ◽

G. Barchetti ◽

I. Ceravolo ◽

G. Simone ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Detection ◽

Detection Rate ◽

Transrectal Ultrasound ◽

Multiparametric Mri ◽

Cancer Detection Rate ◽

Targeted Biopsy ◽

Prostate Cancer Detection ◽

Cad System

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Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: The role of systematic and targeted biopsies

Cancer ◽

10.1002/cncr.29874 ◽

2016 ◽

Vol 122 (6) ◽

pp. 884-892 ◽

Cited By ~ 219

Author(s):

Christopher P. Filson ◽

Shyam Natarajan ◽

Daniel J.A. Margolis ◽

Jiaoti Huang ◽

Patricia Lieu ◽

...

Keyword(s):

Prostate Cancer ◽

Magnetic Resonance ◽

Cancer Detection ◽

Fusion Biopsy ◽

Prostate Cancer Detection ◽

Targeted Biopsies

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Diagnostic accuracy of Multiparametric MRI in detection of prostate cancer compared with histopathology obtained by MRI directed TRUS guided cognitive fusion biopsy are T2WI, DWI and DCE enough for Indian scenario

MedPulse International Journal of Radiology ◽

10.26611/10132013 ◽

2021 ◽

Vol 20 (1) ◽

pp. 10-12

Author(s):

Mallinath Biradar ◽

Keyword(s):

Prostate Cancer ◽

Diagnostic Accuracy ◽

Predictive Value ◽

Prostatic Cancer ◽

Tertiary Care ◽

Multiparametric Mri ◽

Care Hospital ◽

Cognitive Fusion ◽

Fusion Biopsy ◽

Indian Scenario

Background: The incidence of prostatic carcinoma is increasing worldwide. With its high resolution, ability to provide excellent tissue characterization and multiplanar imaging capabilities, multi-parametric magnetic resonance imaging (mpMRI) plays a crucial role in detection, local staging and follow-up of carcinoma prostate. It also helps guide targeted biopsies in initial biopsy negative patient. Objectives: Study diagnostic accuracy of mp-MRI and primarily that of the three MR sequences T2, DWI and DCE in detection of prostatic cancer by correlating them with histopathology and thus whether it is feasible for a short MRI of 3 sequences to be used on a large scale in Indian scenario. Materials and Methods: A prospective study was done at a tertiary care hospital between April 2017 to November 2018 in which 50 patients who presented with suspicion of prostate cancer were referred to radiology department for evaluation using MRI. MRIexamination was done using 3T Siemens Magnetom Verio. Followed by this MRI directed TRUS guided cognitive fusion biopsy was done from the prostate. Samples were sent for histopathology. Results: Out of 50 cases studied, 24 cases (48%) were found to be malignant and 26 cases (52 %) were benign on histopathology. In our study, combined T2 + DWI + DCE gave sensitivity of 95.83 %, specificity of 57.69%, positive predictive value of 68.21 % and negative predictive value of 93.75%. Conclusion: Multiparametric MRI using T2, DWI and DCE has a high diagnostic accuracy for evaluation of prostatic cancer.

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Role of multiparametric magnetic resonance and ultrasound-guided/MR fusion biopsy in patients with low-risk prostate cancer suitable for active surveillance

Journal of Radiological Review ◽

10.23736/s2283-8376.19.00211-0 ◽

2019 ◽

Vol 6 (4) ◽

Author(s):

Federica Ciccarese ◽

Caterina Gaudiano ◽

Beniamino Corcioni ◽

Riccardo Schiavina ◽

Michelangelo Fiorentino ◽

...

Keyword(s):

Prostate Cancer ◽

Magnetic Resonance ◽

Active Surveillance ◽

Low Risk ◽

Ultrasound Guided ◽

Fusion Biopsy ◽

Risk Prostate Cancer ◽

Low Risk Prostate Cancer

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Predictive role of Trimprob associated with multiparametric MRI in the diagnosis of prostate cancer

International braz j urol ◽

10.1590/s1677-5538.ibju.2015.0714 ◽

2017 ◽

Vol 43 (1) ◽

pp. 29-35

Author(s):

Gustavo Cardoso Guimaraes ◽

◽

Walter Henriques da Costa ◽

Renato Almeida Rosa ◽

Stênio Zequi ◽

...

Keyword(s):

Prostate Cancer ◽

Multiparametric Mri ◽

Predictive Role

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The role of MRI/TRUS fusion biopsy in the diagnosis of clinically significant prostate cancer

Therapeutic Advances in Urology ◽

10.1177/1756287220916613 ◽

2020 ◽

Vol 12 ◽

pp. 175628722091661

Author(s):

Andrea Benelli ◽

Chiara Vaccaro ◽

Sonia Guzzo ◽

Carlotta Nedbal ◽

Virginia Varca ◽

...

Keyword(s):

Active Surveillance ◽

Cancer Detection ◽

Detection Rate ◽

Transrectal Ultrasound ◽

Fusion Biopsy ◽

Clinically Significant ◽

Biopsy Gleason Score ◽

Prostate Cancers ◽

Negative Biopsies

Background: The aim of this work is to evaluate the detection rate of magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided biopsy for clinically significant prostate cancers (Cs PCas), with particular interest in biopsy-naive patients and patients in active surveillance. MRI-targeted biopsy improves cancer detection rate (DR) in patients with prior negative biopsies; the current literature focuses on biopsy naive patients. We also evaluated the pathologic concordance between biopsies and surgical specimens. Methods: MRI/TRUS fusion-guided biopsies were performed between February 2016 and February 2019. Patients with previous negative biopsies, biopsy-naive or in active surveillance (AS) were included. Cs PCas were defined through Epstein’s criteria. Results: A total of 416 men were enrolled. The overall DRs and Cs PCa DRs were 49% and 34.3%, respectively. Cs PCas were 17.2%, 44.9% and 73.4%, respectively for PI-RADS 3, 4 or 5. Among biopsy-naive patients, 34.8% were found to have a Cs PCa, while a 43.6% tumour upgrading was achieved in men with a low risk of PCa. In patients who underwent radical prostatectomy (RP), the concordance between biopsy Gleason score (GS) (bGS) and pathological GS (pGS) was 90.8%. Conclusion: Our study highlights the role of MRI/TRUS fusion prostate biopsy in the detection of PCa in patients with previous negative biopsies focusing on Cs PCa diagnosis. The MRI/TRUS fusion biopsy is also emerging as a diagnostic tool in biopsy-naïve patients and deserves a fundamental role in AS protocols. A greater concordance between bGS and pGS can be achieved with targeted biopsies.

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Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

BioMed Research International ◽

10.1155/2014/316272 ◽

2014 ◽

Vol 2014 ◽

pp. 1-23 ◽

Cited By ~ 28

Author(s):

Flavio Barchetti ◽

Valeria Panebianco

Keyword(s):

Prostate Cancer ◽

Radical Prostatectomy ◽

Local Recurrence ◽

Locoregional Recurrence ◽

Multiparametric Mri ◽

Cochrane Library ◽

Published Data ◽

Detection And Localization ◽

The Impact

The clinical suspicion of local recurrence of prostate cancer (PCa) after radical prostatectomy (RP) and after radiation therapy (RT) is based on the onset of biochemical failure. The aim of this paper was to review the current role of multiparametric-MRI (mp-MRI) in the detection of locoregional recurrence. A systematic literature search using the Medline and Cochrane Library databases was performed from January 1995 up to November 2013. Bibliographies of retrieved and review articles were also examined. Only those articles reporting complete data with clinical relevance for the present review were selected. This review article is divided into two major parts: the first one considers the role of mp-MRI in the detection of PCa local recurrence after RP; the second part provides an insight about the impact of mp-MRI in the depiction of locoregional recurrence after RT (interstitial or external beam). Published data indicate an emerging role for mp-MRI in the detection and localization of locally recurrent PCa both after RP and RT which represents an information of paramount importance to perform focal salvage treatments.

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