scholarly journals Plasma Concentration of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Is Elevated in Monkeys With Hyperhomocyst(e)inemia or Hypercholesterolemia

2000 ◽  
Vol 20 (6) ◽  
pp. 1557-1564 ◽  
Author(s):  
Rainer H. Böger ◽  
Stefanie M. Bode-Böger ◽  
Karsten Sydow ◽  
Donald D. Heistad ◽  
Steven R. Lentz
Keyword(s):  
Nitric Oxide ◽  
Plasma Concentration ◽  
Nitric Oxide Synthase ◽  
Asymmetric Dimethylarginine ◽  
Endogenous Inhibitor ◽  
Oxide Synthase

scholarly journals Plasma Concentration of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Is Elevated in Hyperthyroid Patients

2002 ◽  
Vol 87 (12) ◽  
pp. 5636-5640 ◽  
Author(s):  
Carlos Hermenegildo ◽  
Pascual Medina ◽  
Marta Peiró ◽  
Gloria Segarra ◽  
José M. Vila ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Plasma Concentration ◽  
Nitric Oxide Synthase ◽  
Asymmetric Dimethylarginine ◽  
Endogenous Inhibitor ◽  
Oxide Synthase ◽  
Hyperthyroid Patients

Effect of asymmetric dimethyl arginine on nitric oxide synthase activity in normal and pre-eclamptic placentae

1995 ◽  
Vol 7 (6) ◽  
pp. 1581 ◽  
Author(s):  
RG King ◽  
Iulio JL Di ◽  
NM Gude ◽  
SP Brennecke
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Asymmetric Dimethylarginine ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Endogenous Inhibitor ◽  
Asymmetric Dimethyl Arginine ◽  
Dimethyl Arginine ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

An endogenous inhibitor of nitric oxide synthase (NOS), NG,NG dimethylarginine (asymmetric dimethylarginine, ADMA), which is present in human plasma and urine, has been reported to be elevated in the plasma of women with pre-eclampsia. As ADMA inhibition may contribute to reduced placental NOS activity observed in pre-eclampsia, the aim of this study was to compare the effects of ADMA on placental NOS activity from pre-eclamptic and normal pregnancies (gestational ages 38.4 +/- 0.9 and 38.3 +/- 0.3 weeks respectively). NOS activity was determined by measuring the conversion of [3H]L-arginine to [3H]L-citrulline in homogenates of normal and pre-eclamptic placentae in the absence and presence of increasing concentrations of ADMA (1-100 microM). The IC50 for ADMA for the pre-eclamptic placentae (22.1 +/- 2.1 microM, n = 6) was not significantly different from that for the normal placentae (18.8 +/- 1.4 microM, n = 6). When ADMA and L-arginine in homogenates was removed by ion exchange chromatography and exogenous L-arginine replaced (32 microM), the IC50 for the pre-eclamptic placentae (19.5 +/- 1.8 microM, n = 6) was not significantly different than that for the normal placentae (20.9 +/- 1.0 microM, n = 6), and NOS activity in the absence of endogenous and exogenous ADMA was still reduced in pre-eclamptic placentae. These results provide no evidence that the sensitivity of placental NOS to ADMA is affected by pre-eclampsia, or that placental ADMA contributes to the reduction of placental NOS in pre-eclampsia.

Impact of Catheter Arteriography on the Serum Level of Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase

2008 ◽  
Vol 31 (3) ◽  
pp. 490-495 ◽  
Author(s):  
Ugur Bozlar ◽  
Mehmet Sahin Ugurel ◽  
Omer Ozcan ◽  
Erdinc Cakir ◽  
Bahri Ustunsoz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Serum Level ◽  
Asymmetric Dimethylarginine ◽  
Endogenous Inhibitor ◽  
Oxide Synthase
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