scholarly journals Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease

Circulation ◽  
1998 ◽  
Vol 97 (5) ◽  
pp. 425-428 ◽  
Author(s):  
Paul M. Ridker ◽  
Mary Cushman ◽  
Meir J. Stampfer ◽  
Russell P. Tracy ◽  
Charles H. Hennekens
Author(s):  
Mohammed Qintar ◽  
Puza P Sharma ◽  
Yuanyuan Tang ◽  
Philip Jones ◽  
Yashashwi Pokharel ◽  
...  

Background: Elevated hs-CRP is associated with worse cardiovascular outcomes in patients with acute myocardial infarction (AMI), but little is known about predictors of elevated hs-CRP after AMI. Methods: TRIUMPH and VIRGO are prospective AMI registries that assessed hs-CRP levels 30 days after AMI. TRIUMPH assessed hs-CRP levels at 6 months. Multivariable regression analysis was conducted to examine predictors of elevated hs-CRP [≥2.0 mg/L] at 30 days and at 6 months after an AMI (TRIUMPH only). Results: Of 3410 patients in both registries, 58.6% had elevated hs-CRP 30 days post AMI. Patients with elevated hs-CRP were more likely to be female, black, obese, smokers, to have had higher LDL-C at the time of their AMI, with more peripheral vascular disease and history of heart failure, and were less likely to have had a prior PCI (Table). In TRIUMPH, baseline hs-CRP ≥2 mg/L (n=1301) was significantly associated with elevated hs-CRP at 6 months (p<0.001). Patients with elevated hs-CRP at 6 months (n=407) were more likely to be black, obese, smokers, have peripheral vascular disease and have higher baseline hs-CRP. Conclusions: hs-CRP remains elevated in a large proportion of patients following AMI. We identified several predictors of elevated hs-CRP at 1 and 6 months post AMI. Further studies are needed to validate the findings and understand the utility of routine screening of hs-CRP in post AMI patients.


2003 ◽  
Vol 88 (1) ◽  
pp. 105-106 ◽  
Author(s):  
Bon Kwon Koo ◽  
Donghoon Choi ◽  
Hee Doo Kyung ◽  
Yangsoo Jang ◽  
Won-Heum Shim ◽  
...  

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