Autonomic Nervous System Dysfunction in Elderly Hypertensive Patients With Abnormal Diurnal Blood Pressure Variation

Hypertension ◽  
1997 ◽  
Vol 30 (6) ◽  
pp. 1504-1510 ◽  
Author(s):  
Kazuomi Kario ◽  
Keiji Motai ◽  
Takeshi Mitsuhashi ◽  
Takaaki Suzuki ◽  
Yukinori Nakagawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Pressure Variation ◽  
Autonomic Nervous System Dysfunction ◽  
Hypertensive Patients ◽  
Autonomic Nervous ◽  
Blood Pressure Variation ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

Role of autonomic nervous system in circadian blood pressure variation

1996 ◽  
Vol 6 ◽  
pp. S49
Author(s):  
M.J. Carvalho ◽  
F. Bomsma ◽  
M.J. Lima ◽  
A. Oliveira ◽  
A. Man in't Veld ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Pressure Variation ◽  
Autonomic Nervous ◽  
Circadian Blood Pressure ◽  
Blood Pressure Variation

Abstract TMP97: Autonomic Nervous System Dysfunction Correlates With Increased Blood Pressure Variability After Acute Ischemic, But Not Hemorrhagic, Stroke

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Adam H de Havenon ◽  
Melissa Cortez ◽  
Cecilia Peterson ◽  
Fa Tuuhetaufa ◽  
Nils Petersen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Blood Pressure Variability ◽  
Hemorrhagic Stroke ◽  
Light Stimulus ◽  
Pupillary Response ◽  
Autonomic Nervous System Dysfunction ◽  
Autonomic Nervous ◽  
The Mean

Background: Elevated blood pressure variability (BPV) in the days after acute stroke onset is associated with worse outcome. However, the mechanism of increased BPV remains unknown, but may be due to dysfunction of the autonomic nervous system, which can be measured by pupil response to a light stimulus. Methods: This is a retrospective study of 109 patients in a neurocritical care unit: 45 with acute ischemic stroke (AIS), 44 with intracerebral hemorrhage (ICH), and 20 with subarachnoid hemorrhage (SAH). The primary outcome is BPV, measured as standard deviation of SBP (SD), using all blood pressures from admission to 72 hours later. The primary predictors are pupillary light reflexes (PLR) from the same period, measured with a bedside pupilometer, the NPi-200. We used linear regression to evaluate the association between PLRs and BPV, and adjusted for patient age and gender. Results: The mean (SD) age was 60.7 (16.4) and 58.7% were male. The mean (SD) number of blood pressure and PLR measurements were 30.0 (9.0) and 10.4 (7.3). We found that parasympathetically mediated PLR measures were associated with BPV in AIS patients (Table 1), but no consistent pattern emerged in ICH or SAH patients (all p>0.05). The relationships between BPV and PLR for AIS patients were linear in nature (Figure 1), and were consistent with parasympathetic hypofunction in patients with the greatest BPV. Conclusions: Elevated BPV is associated with parasympathetic hypofunction, as measured by pupillary response to light, after acute ischemic, but not hemorrhagic, stroke. Further research is needed to better understand this relationship as it may represent a therapeutic target for BPV reduction.

scholarly journals Blood pressure normalization post-jugular venous balloon angioplasty

2013 ◽  
Vol 30 (4) ◽  
pp. 280-287 ◽  
Author(s):  
Zohara Sternberg ◽  
Prabhjot Grewal ◽  
Steven Cen ◽  
Frances DeBarge-Igoe ◽  
Jinhee Yu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Balloon Angioplasty ◽  
Baseline Blood Pressure ◽  
Autonomic Nervous System Dysfunction ◽  
Jugular Veins ◽  
Autonomic Nervous ◽  
Multiple Sclerosis Patients ◽  
Internal Jugular Veins

Objective This study is the first in a series investigating the relationship between autonomic nervous system dysfunction and chronic cerebrospinal venous insufficiency in multiple sclerosis patients. We screened patients for the combined presence of the narrowing of the internal jugular veins and symptoms of autonomic nervous system dysfunction (fatigue, cognitive dysfunction, sleeping disorders, headache, thermal intolerance, bowel/bladder dysfunction) and determined systolic and diastolic blood pressure responses to balloon angioplasty. Methods The criteria for eligibility for balloon angioplasty intervention included ≥50% narrowing in one or both internal jugular veins, as determined by the magnetic resonance venography, and ≥3 clinical symptoms of autonomic nervous system dysfunction. Blood pressure was measured at baseline and post-balloon angioplasty. Results Among patients who were screened, 91% were identified as having internal jugular veins narrowing (with obstructing lesions) combined with the presence of three or more symptoms of autonomic nervous system dysfunction. Balloon angioplasty reduced the average systolic and diastolic blood pressure. However, blood pressure categorization showed a biphasic response to balloon angioplasty. The procedure increased blood pressure in multiple sclerosis patients who presented with baseline blood pressure within lower limits of normal ranges (systolic ≤105 mmHg, diastolic ≤70 mmHg) but decreased blood pressure in patients with baseline blood pressure above normal ranges (systolic ≥130 mmHg, diastolic ≥ 80 mmHg). In addition, gender differences in baseline blood pressure subcategories were observed. Discussion The coexistence of internal jugular veins narrowing and symptoms of autonomic nervous system dysfunction suggests that the two phenomena may be related. Balloon angioplasty corrects blood pressure deviation in multiple sclerosis patients undergoing internal jugular vein dilation. Further studies should investigate the association between blood pressure deviation and internal jugular veins narrowing, and whether blood pressure normalization affects Patient's clinical outcomes.

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