Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform

Cardiovascular events are more common in the winter months, possibly because of hemodynamic alterations in response to cold exposure. The purpose of this study was to determine the effect of acute facial cooling on central aortic pressure, arterial stiffness, and wave reflection. Twelve healthy subjects (age 23 ± 3 yr; 6 men, 6 women) underwent supine measurements of carotid-femoral pulse wave velocity (PWV), brachial artery blood pressure, and central aortic pressure (via the synthesis of a central aortic pressure waveform by radial artery applanation tonometry and generalized transfer function) during a control trial (supine rest) and a facial cooling trial (0°C gel pack). Aortic augmentation index (AI), an index of wave reflection, was calculated from the aortic pressure waveform. Measurements were made at baseline, 2 min, and 7 min during each trial. Facial cooling increased ( P < 0.05) peripheral and central diastolic and systolic pressures. Central systolic pressure increased more than peripheral systolic pressure (22 ± 3 vs. 15 ± 2 mmHg; P < 0.05), resulting in decreased pulse pressure amplification ratio. Facial cooling resulted in a robust increase in AI and a modest increase in PWV (AI: −1.4 ± 3.8 vs. 21.2 ± 3.0 and 19.9 ± 3.6%; PWV: 5.6 ± 0.2 vs. 6.5 ± 0.3 and 6.2 ± 0.2 m/s; P < 0.05). Change in mean arterial pressure but not PWV predicted the change in AI, suggesting that facial cooling may increase AI independent of aortic PWV. Facial cooling and the resulting peripheral vasoconstriction are associated with an increase in wave reflection and augmentation of central systolic pressure, potentially explaining ischemia and cardiovascular events in the cold.

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Blind Identification of the Central Aortic Pressure Waveform from Multiple Peripheral Arterial Pressure Waveforms

2006 International Conference of the IEEE Engineering in Medicine and Biology Society ◽

10.1109/iembs.2006.260538 ◽

2006 ◽

Cited By ~ 1

Author(s):

Gokul Swamy ◽

Qi Ling ◽

Tongtong Li ◽

Ramakrishna Mukkamala

Keyword(s):

Arterial Pressure ◽

Aortic Pressure ◽

Blind Identification ◽

Pressure Waveform ◽

Central Aortic Pressure ◽

Peripheral Arterial

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Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope

Heart and Vessels ◽

10.1007/s00380-014-0576-6 ◽

2014 ◽

Vol 31 (1) ◽

pp. 74-79 ◽

Cited By ~ 3

Author(s):

Simon Pecha ◽

Samer Hakmi ◽

Iris Wilke ◽

Yalin Yildirim ◽

Boris Hoffmann ◽

...

Keyword(s):

Pulse Wave ◽

Vasovagal Syncope ◽

Aortic Pressure ◽

Pulse Wave Analysis ◽

Pressure Waveform ◽

Wave Analysis

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Indices of central aortic pressure waveform and ventricular function

Journal of Hypertension ◽

10.1097/hjh.0000000000000883 ◽

2016 ◽

Vol 34 (4) ◽

pp. 634-636

Author(s):

Alberto Avolio ◽

Mark Butlin

Keyword(s):

Ventricular Function ◽

Aortic Pressure ◽

Pressure Waveform ◽

Central Aortic Pressure

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Noninvasive Estimation of Intracranial Pressure Waveform from Central Aortic Pressure Waveform

World Neurosurgery ◽

10.1016/j.wneu.2018.10.079 ◽

2019 ◽

Vol 121 ◽

pp. 257-258

Author(s):

Karen Brastad Evensen ◽

Per Kristian Eide

Keyword(s):

Intracranial Pressure ◽

Aortic Pressure ◽

Pressure Waveform ◽

Central Aortic Pressure ◽

Noninvasive Estimation ◽

Intracranial Pressure Waveform

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Reconstruction of Central Aortic Pressure Waveform Using Adaptive Multi-Channel Identification

2006 International Conference of the IEEE Engineering in Medicine and Biology Society ◽

10.1109/iembs.2006.4398172 ◽

2006 ◽

Author(s):

Jin-Oh Hahn ◽

Andrew Reisner ◽

Horacio Hojman ◽

H. Harry Asada

Keyword(s):

Aortic Pressure ◽

Pressure Waveform ◽

Channel Identification ◽

Central Aortic Pressure

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Abstract 2432: Effect of Left Ventricular Systolic Dysfunction on Wasted Left Ventricular Energy and Tension-Time Index

Circulation ◽

10.1161/circ.118.suppl_18.s_725-d ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Scott J Denardo ◽

Wilmer W Nichols

Keyword(s):

Heart Failure ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Aortic Pressure ◽

Left Ventricular ◽

Systemic Hypertension ◽

Pressure Waveform ◽

Ventricular Systolic Dysfunction ◽

Time Index ◽

Tension Time

Information obtained from the aortic pressure waveform is affected by age, physical condition, systemic hypertension, diabetes mellitus and coronary artery disease. However, alterations in the aortic pressure waveform in patients (pts) with heart failure and left ventricular systolic dysfunction (LVSD) have not been fully described, including a description of the effect on wasted LV pressure energy and tension-time index. Non-invasive high-fidelity radial artery tonometry was used for data acquisition, and a mathematical transfer function used to generate aortic pressure waveforms (see figure ). Pulse wave analysis (PWA) of the aortic pressure waveform was used to obtain information associated with LV/vascular coupling in 23 pts age 55±9.5 yrs with LVSD (mean LV ejection fraction, 22±6%) and compared to data collected from 23 normal subjects matched for age, gender, height, weight and heart rate. Measurements obtained using PWA in heart failure pts with LVSD demonstrate decreased wasted LV energy and tension time index, consistent with poor LV mechanical performance, in addition to decreased unaugmented pressure, pulse pressure, ejection duration and augmentation index. Further standardization of these aortic pressure waveform findings in heart failure pts may allow for the clinical use of arterial PWA to non-invasively estimate LVSD.

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