Renal prostaglandin synthesis in the Goldblatt hypertensive rat.

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

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Alkamides from Echinacea angustifolia roots inhibit Cyclooxygenase-2-dependent Prostaglandin synthesis in Human Neuroglioma Cells

Planta Medica ◽

10.1055/s-2006-950070 ◽

2006 ◽

Vol 72 (11) ◽

Cited By ~ 1

Author(s):

K Woelkart ◽

R Bauer ◽

B Hinz

Keyword(s):

Prostaglandin Synthesis ◽

Cyclooxygenase 2 ◽

Echinacea Angustifolia

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THE FALL OF BLOOD PRESSURE FOLLOWING INDUCTION OF DECIDUOMATA IN STEROID HYPERTENSIVE RATS RECEIVING PROGESTERONE

Acta Endocrinologica ◽

10.1530/acta.0.0590227 ◽

1968 ◽

Vol 59 (2) ◽

pp. 227-234 ◽

Cited By ~ 1

Author(s):

H. C. Moore ◽

I. Cserhati ◽

F. P. Biliczki

Keyword(s):

Blood Pressure ◽

Hypotensive Effect ◽

Hypertensive Rats ◽

Pregnant Rats ◽

Hypertensive Rat ◽

Equivalent Time ◽

Metrial Gland ◽

Blood Pressure Responses ◽

A Minor ◽

Maternal Decidua

ABSTRACT Experimental deciduomata and progesterone together lower the blood pressure in the steroid hypertensive rat from the 5th to 10th day of decidual growth i. e. from the 10th to 15th day of pseudopregnancy. This would suggest that the fall of blood pressure at an equivalent time of gestation in hypertensive pregnant rats could be due to the maternal decidua under the influence of progesterone. It is further considered that the metrial gland of the deciduoma is more likely to be responsible for the hypotensive effect and by comparison that the metrial gland is implicated in the hypotensive effect of pregnancy. Progesterone alone also exerts a minor hypotensive effect in those animals in which a nephrectomy forms part of the hypertension regimen and indicates one way in which a maternal renal factor could influence blood pressure responses in hypertensive pregnant rats.

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