scholarly journals Does Apolipoprotein E Genotype Influence the Risk of Ischemic Stroke, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage?

Stroke ◽  
2006 ◽  
Vol 37 (2) ◽  
pp. 364-370 ◽  
Author(s):  
Cathie Sudlow ◽  
Nahara Ananí Martínez González ◽  
Jennifer Kim ◽  
Catriona Clark
Keyword(s):  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Intracerebral Hemorrhage ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

Association between Apolipoprotein E Polymorphism and Clinical Outcome after Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage

2021 ◽  
pp. 1-10
Author(s):  
Wen Pan ◽  
Min Zhang ◽  
Zhenping Guo ◽  
Wenfeng Xiao ◽  
Chao You ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Clinical Outcome ◽  
Intracerebral Hemorrhage ◽  
Apolipoprotein E ◽  
Functional Outcomes ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Fixed Effects Models ◽  
Increased Risk

<b><i>Backgrounds:</i></b> Previous studies reported inconsistent results regarding associations between apolipoprotein E (<i>APOE</i>) polymorphism and clinical outcomes after ischemic stroke (IS), intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH). Thus, the study was designed to make a systematic review and meta-analysis regarding the association between <i>APOE</i> polymorphism and clinical outcome after IS, ICH, and SAH. <b><i>Methods:</i></b> To identify studies eligible for this meta-analysis, we searched for articles published before August 2021 in the databases (PubMed, Web of Science, and Google Scholar). We used STATA 12.0 software to compute hazard ratios (HRs) and their 95% confidence intervals (CIs) regarding <i>APOE</i> polymorphism and clinical outcome after IS, ICH, and SAH. <b><i>Results:</i></b> Meta-analysis showed no significant association between <i>APOE</i> polymorphism and functional outcome after IS with fixed effects models (ε4 carrier vs. non-ε4 carrier: HR, 1.00; 95% CI: 0.83–1.21, <i>I</i><sup>2</sup> = 29.4%, <i>p</i> = 0.183; ε2 carrier vs. non-ε2 carrier: HR, 0.92; 95% CI: 0.72–1.16, <i>I</i><sup>2</sup> = 15.6%, <i>p</i> = 0.307). Meta-analysis showed that ICH patients carrying ε4 allele have increased risk of poor outcome in Caucasian population with fixed effects models (ε4 carrier vs. non-ε4 carrier: HR, 1.75; 95% CI: 1.19–2.57, <i>I</i><sup>2</sup> = 0.0%, <i>p</i> = 0.543). Meta-analysis showed no significant association between <i>APOE</i> polymorphism and functional outcomes after SAH with random effects models (ε4 carrier vs. non-ε4 carrier: HR, 1.51; 95% CI: 0.80–2.84, <i>I</i><sup>2</sup> = 57.1%, <i>p</i> = 0.022). <b><i>Conclusions:</i></b> In conclusion, the present study demonstrated <i>APOE</i> ε4 carriers show worse functional outcomes after ICH, but not after IS or SAH. More large-scale studies were critical to explore the association between <i>APOE</i> polymorphism and clinical outcome after IS, ICH, and SAH.

Apolipoprotein E genotype in the subarachnoid hemorrhage population

2005 ◽  
Vol 7 (2) ◽  
pp. 143-144 ◽  
Author(s):  
S Alexander ◽  
M Kerr ◽  
YP Conley ◽  
Y Kong ◽  
H Yonas
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

scholarly journals Apolipoprotein E Genotype Predicts Hematoma Expansion in Lobar Intracerebral Hemorrhage

Stroke ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. 1490-1495 ◽  
Author(s):  
H. Bart Brouwers ◽  
Alessandro Biffi ◽  
Alison M. Ayres ◽  
Kristin Schwab ◽  
Lynelle Cortellini ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Apolipoprotein E ◽  
Hematoma Expansion ◽  
Apolipoprotein E Genotype

scholarly journals Prospective Study of Apolipoprotein E Genotype and Functional Outcome Following Ischemic Stroke

2000 ◽  
Vol 57 (10) ◽  
Author(s):  
Mark O. McCarron ◽  
Keith W. Muir ◽  
James A. R. Nicoll ◽  
Janice Stewart ◽  
Yvonne Currie ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Prospective Study ◽  
Apolipoprotein E ◽  
Functional Outcome ◽  
Apolipoprotein E Genotype

Abstract WMP98: Apolipoprotein E Genotype Predicts Anticoagulation-associated Intracerebral Hemorrhage Recurrence

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Sebastian Urday ◽  
Alessandro Biffi ◽  
Axana Rodriguez-Torres ◽  
Marco Pasi ◽  
Christina Kourkoulis ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

The Influence of Apolipoprotein E Genotype on Outcome after Spontaneous Subarachnoid Hemorrhage: A Preliminary Study

Neurosurgery ◽  
2001 ◽  
Vol 48 (5) ◽  
pp. 1006-1011
Author(s):  
Laurence T. Dunn ◽  
Elaine Stewart ◽  
Gordon D. Murray ◽  
James A.R. Nicoll ◽  
Graham M. Teasdale
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Apolipoprotein E ◽  
Preliminary Study ◽  
Spontaneous Subarachnoid Hemorrhage ◽  
Apolipoprotein E Genotype

scholarly journals Apolipoprotein E Genotype Is Associated With CT Angiography Spot Sign in Lobar Intracerebral Hemorrhage

Stroke ◽  
2012 ◽  
Vol 43 (8) ◽  
pp. 2120-2125 ◽  
Author(s):  
H. Bart Brouwers ◽  
Alessandro Biffi ◽  
Kristen A. McNamara ◽  
Alison M. Ayres ◽  
Valerie Valant ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Apolipoprotein E ◽  
Ct Angiography ◽  
Spot Sign ◽  
Apolipoprotein E Genotype

scholarly journals Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients

Medicine ◽  
2017 ◽  
Vol 96 (50) ◽  
pp. e8964 ◽  
Author(s):  
Yajing Zhang ◽  
Shuling Liu ◽  
Wei Yue ◽  
Zhihong Shi ◽  
Yalin Guan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Apolipoprotein E ◽  
Stroke Patients ◽  
Apolipoprotein E Genotype

scholarly journals Stroke subtypes in southern Iran

2015 ◽  
Vol 4 (1) ◽  
pp. 47-49
Author(s):  
Rasool Safari ◽  
Afshin Borhanihaghighi ◽  
Seyed Taghi Heydari ◽  
Anahid Safari ◽  
Salvador Cruz-Flores
Keyword(s):  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Intracerebral Hemorrhage ◽  
Single Center ◽  
Stroke Patients ◽  
Stroke Subtype ◽  
Younger Patients ◽  
Single Center Study ◽  
Length Of Hospitalization ◽  
Center Study

Objective: To investigate about frequency of different subtypes of stroke in south of IranMethods: This  is a retrospective, single-center study  conducted at Namazi Hospital, Shiraz, south of Iran. Age, sex, length of hospitalization and  mortality  of  stroke patients were recorded by reviewing hospital medical records.Results: 16 351 patients (53.6% male, 46.4%female) were recruited.  Ischemic stroke (10750 patients, 65.7%), intracerebral hemorrhage(3282 patients,20.1%) and subarachnoid hemorrhage(1057 patients,6.5%)  were the most common subtypes of stroke, respectively. In 1262 patients (7.7%) the stroke subtype could not been specified. Ischemic stroke and intracerebral hemorrhage were more common in men but subarachnoid hemorrhage was more common in women. Subarachnoid hemorrhage occurred significantly in younger patients. Mortality was significantly higher in intracerebral hemorrhage. Hospital stay was significantly longer in subarachnoid hemorrhage group.Conclusion: the distribution of the different  subtypes of stroke in Iran is similar to Caucasians.

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