scholarly journals Protein Tyrosine Phosphatase 1B Impairs Diabetic Wound Healing Through Vascular Endothelial Growth Factor Receptor 2 Dephosphorylation

2015 ◽  
Vol 35 (1) ◽  
pp. 163-174 ◽  
Author(s):  
Jing Zhang ◽  
Limin Li ◽  
Jing Li ◽  
Yuan Liu ◽  
Chen-Yu Zhang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Growth Factor Receptor ◽  
Protein Tyrosine Phosphatase 1B ◽  
Vascular Endothelial ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Endothelial Growth Factor

Plasma Exosomes Loaded pH-Responsive Carboxymethylcellulose Hydrogel Promotes Wound Repair by Activating the Vascular Endothelial Growth Factor Signaling Pathway in Type 1 Diabetic Mice

2021 ◽  
Vol 17 (10) ◽  
pp. 2021-2033
Author(s):  
Lijuan Huang ◽  
Yijie Shi ◽  
Mengdie Li ◽  
Tao Wang ◽  
Liang Zhao
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Wound Repair ◽  
Vascular Endothelial ◽  
Diabetic Wound ◽  
Ph Responsive ◽  
Diabetic Wound Healing ◽  
Endothelial Growth Factor

Chronic wound healing plagues thousands of diabetic patients and brings social and economic burdens. Plasma exosomes (P-Exos), regarded as nanosized therapeutic agents, have shown therapeutic efficacy in promoting diabetic wound healing. The present work prepared the P-Exos-loaded pH-responsive carboxymethylcellulose (P-Exos-loaded CMC) hydrogel to investigate its ability to accelerate diabetic wound healing and to explore its underlying mechanisms. The results showed that the P-Exos-loaded CMC hydrogel was an effective therapeutic agent for accelerating diabetic wound repair. It promoted the local wound healing process in diabetic type 1 mice and enhanced angiogenesis and re-epithelialization via activating angiogenesis-related pathways mediated by vascular endothelial growth factor (VEGF).

scholarly journals Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing

2006 ◽  
Vol 169 (3) ◽  
pp. 1080-1087 ◽  
Author(s):  
Anne Saaristo ◽  
Tuomas Tammela ◽  
Anniina Fārkkilā ◽  
Marika Kärkkäinen ◽  
Erkki Suominen ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Wound Healing ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Factor C ◽  
Endothelial Growth Factor
Sign in / Sign up

Export Citation Format

Share Document