Abstract 1691: Stages of Chronic Kidney Disease Correlate with Major Adverse Cardiac Events as well as Late Lumen Loss Following the Sirolimus Eluting Coronary Stent

Background: Chronic Kidney Disease (CKD) is considered as a risk factor for development of cardiovascular disease. However, it is unclear whether CKD has association with prognosis following the drug eluting stent implantation. Methods and Results : The Cypher coronary stents were implanted to 302 lesions in 249 patients who underwent elective PCI between January 2005 and April 2006. Average age was 66.3 ± 9.7 and male gender was 80.3%. Diabetes was found in 47% of the patients including 16% of insulin treatment. Stages of CKD are shown in the table 1 and 2 . AHA/ACC lesion type B2/C was 62%. Cypher stents were implanted at maximum pressure at 17.3 ± 3.0 atm. Intravascular ultrasound was used in 92% of the procedure. Clinical follow-up data were available in 89.9 % at 1 year although angiographic follow-up was performed in 73.1% at 8 months. Major adverse cardiac events were frequently observed in association with stages of CKD as shown in the table 1 . Stages of CKD have correlation with late lumen loss at 8 months (Table 2 ). Furthermore, in-stent late lumen loss inversely correlated with glomerular filtration rate (GFR) (R = −0.18, p = 0.0097). Conclusion : Stages of CKD have correlation with major adverse cardiac events as well as late lumen loss following the sirolimus eluting stent implantation. Clinical follow-up at 1 year of study stratified by stages of CKD Angiographic data of study stratified by stages of CKD