Abstract 13293: Acyl-coa Binding Protein is Marker of Myocardial Ischemia

Background: We recently applied a liquid chromatography tandem mass spectrometry (LC-MS/MS) based proteomics platform to plasma samples from individuals undergoing a “planned” myocardial infarction (PMI; alcohol ablation for hypertrophic cardiomyopathy) and identified acyl-CoA binding protein (ACBP) as a potential circulating biomarker of myocardial injury. ACBP is a 10 kDa intracellular protein that is highly expressed in cells with a high turn-over of fatty acids such as cardiomyocytes. We sought to determine the site of ACBP release and whether ischemia alone is sufficient to trigger an increment in plasma levels in humans. Methods: Coronary sinus (CS) and peripheral venous samples were obtained simultaneously from PMI patients; peripheral venous samples were obtained from derivation/validation cohorts of subjects undergoing cardiac stress testing. Plasma ACBP levels were measured by immunoassay. Results: In PMI patients (n=11), pre-injury levels of ACBP were comparable in the CS and peripheral samples. As early as 10 min after PMI, ACBP levels were 27% higher in the CS than in the periphery (P = 0.01), and remained 30% higher at 60 minutes (P = 0.02). Next, we studied 105 patients undergoing cardiac stress testing, 52 of whom demonstrated inducible ischemia (cases) and 53 of whom did not (controls). Baseline ACBP levels were comparable in cases and controls. Changes in median ACBP levels after the exercise stress challenge were significantly greater in the ischemic patients (cases) than in the controls (22% increase in cases; 1% decrease in controls; P = 0.0001), findings which were validated in a second cohort of 101 patients subjects (P = 0.002). These findings remained significant in a multivariable model adjusting for age, male sex, diabetes, BMI, smoking, creatinine, hypercholesterolemia, and total minutes of exercise. By contrast, the effects of exercise on established biomarkers (cTnI, NT-proBNP and FABP) did not differ betwen cases and controls. Conclusions: We provide initial verification that ACBP is rapidly released from the injured heart and increases in response not only to infarction but also ischemia. These findings motivate additional clinical studies of this novel biomarker in heterogeneous patient cohorts.

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Comparison of Preoperative Assessment of Patient’s Metabolic Equivalents (METs) Estimated from History versus Measured by Exercise Cardiac Stress Testing

Anesthesiology Research and Practice ◽

10.1155/2018/5912726 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Adam S. Weinstein ◽

Martin I. Sigurdsson ◽

Angela M. Bader

Keyword(s):

Cardiac Failure ◽

Stress Testing ◽

Stress Test ◽

Preoperative Evaluation ◽

Preoperative Assessment ◽

Exercise Stress ◽

Cardiac Stress ◽

Metabolic Equivalents ◽

Cardiac Stress Testing ◽

Cardiac Stress Test

Background. Preoperative anesthetic evaluations of patients before surgery traditionally involves assessment of a patient’s functional capacity to estimate perioperative risk of cardiovascular complications and need for further workup. This is typically done by inquiring about the patient’s physical activity, with the goal of providing an estimate of the metabolic equivalents (METs) that the patient can perform without signs of myocardial ischemia or cardiac failure. We sought to compare estimates of patients’ METs between preoperative assessment by medical history with quantified assessment of METs via the exercise cardiac stress test. Methods. A single-center retrospective chart review from 12/1/2005 to 5/31/2015 was performed on 492 patients who had preoperative evaluations with a cardiac stress test ordered by a perioperative anesthesiologist. Of those, a total of 170 charts were identified as having a preoperative evaluation note and an exercise cardiac stress test. The METs of the patient estimated by history and the METs quantified by the exercise cardiac stress test were compared using a Bland–Altman plot and Cohen’s kappa. Results. Exercise cardiac stress test quantified METs were on average 3.3 METS higher than the METs estimated by the preoperative evaluation history. Only 9% of patients had lower METs quantified by the cardiac stress test than by history. Conclusions. The METs of a patient estimated by preoperative history often underestimates the METs measured by exercise stress testing. This demonstrates that the preoperative assessments of patients’ METs are often conservative which errs on the side of patient safety as it lowers the threshold for deciding to order further cardiac stress testing for screening for ischemia or cardiac failure.

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The ECG in cardiac stress testing: a valuable, but unappreciated source of clues

American Journal of Critical Care ◽

10.4037/ajcc1998.7.4.320 ◽

1998 ◽

Vol 7 (4) ◽

pp. 320-327

Author(s):

LG Futterman ◽

L Lemberg

Keyword(s):

Emergency Department ◽

Clinical Features ◽

Stress Testing ◽

Stress Test ◽

Exercise Stress Test ◽

Accurate Diagnosis ◽

Exercise Stress ◽

Cardiac Stress ◽

Cardiac Stress Testing ◽

Ecg Abnormalities

The ECG exercise stress test is a very potent aid to the clinical diagnosis of CAD. Thorough knowledge of the ECG abnormalities and clinical features related to the stress test are required for an accurate diagnosis. The ECG exercise stress test is not a substitute for clinical acumen. Proper evaluation of the stress test is a clinical art of the skilled clinician. ECG exercise stress testing can be done efficiently and effectively by trained emergency department physicians. As a result, the diagnosis of CAD can be greatly accelerated.

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The early identification of psychosis: can lessons be learnt from cardiac stress testing?

Psychopharmacology ◽

10.1007/s00213-015-4143-3 ◽

2015 ◽

Vol 233 (1) ◽

pp. 19-37 ◽

Cited By ~ 4

Author(s):

Swapnil Gupta ◽

Mohini Ranganathan ◽

Deepak Cyril D’Souza

Keyword(s):

Early Identification ◽

Stress Testing ◽

Cardiac Stress ◽

Cardiac Stress Testing

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Abstract TP165: Cardiac Screening Does not Improve One-year Mortality Among Patients With Cerebrovascular Disease

Stroke ◽

10.1161/str.47.suppl_1.tp165 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Jason J Sico ◽

Fitsum Baye ◽

Laura J Myers ◽

John Concato ◽

Linda S Williams ◽

...

Keyword(s):

High Risk ◽

Cerebrovascular Disease ◽

Stress Testing ◽

Cerebrovascular Event ◽

Mortality Benefit ◽

Cardiac Stress ◽

Cardiac Screening ◽

All Cause Mortality ◽

Cardiac Stress Testing ◽

One Year

Introduction: Guidelines recommend the use of cardiac stress testing to screen for occult coronary heart disease (CHD) among patients with ischemic stroke/TIA who have a ‘high risk’ Framingham Cardiac Risk score (FCRS). It is unclear whether implementation of this guideline confers a mortality benefit among patients with cerebrovascular disease. Hypothesis: We assessed the hypothesis that cardiac stress testing would be associated with lower odds of one-year all-cause mortality. Methods: Administrative data from a sample of 11,306 Veterans admitted to 134 Veterans Health Administration (VHA) facilities with a stroke or TIA in fiscal year 2011 were analyzed. Patients were excluded (n=6915) on the basis of: prior CHD history, receipt of cardiac stress testing within 18-months prior to cerebrovascular event, death within 90 days of discharge, being discharged to hospice, transferred to a non-VHA acute care facility, or missing/unknown race. A FCRS was calculated for each patient; a score of ≥ 20% was classified as ‘high risk’ of having CHD. Administrative data were used to identify whether cardiac stress testing was performed within 90-days after the cerebrovascular event. Logistic regression was used to assess whether cardiac stress testing was associated with one-year all-cause mortality. Results: Of the 4391 eligible patients, 62.8% (2759) had FCRS ≥ 20%, with 4.5% (n=123) of these patients receiving cardiac stress testing within 90 days of discharge. After adjusting for sociodemographic characteristics and medical comorbidities, FCRS ≥ 20% was associated with one-year mortality (aOR=2.18; CI 95 :1.59, 3.00), however, receipt of stress testing was not (aOR=0.59; CI 95 :0.26, 1.30). Conclusion: Cardiac screening did not confer a one-year all-cause mortality benefit among patients with cerebrovascular disease. Additional work is needed to assess outcomes among patients with cerebrovascular disease who are at ‘high risk’ for CHD.

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Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing

New England Journal of Medicine ◽

10.1056/nejmoa042741 ◽

2005 ◽

Vol 353 (18) ◽

pp. 1889-1898 ◽

Cited By ~ 171

Author(s):

Aiden Abidov ◽

Alan Rozanski ◽

Rory Hachamovitch ◽

Sean W. Hayes ◽

Fatma Aboul-Enein ◽

...

Keyword(s):

Stress Testing ◽

Prognostic Significance ◽

Cardiac Stress ◽

Cardiac Stress Testing

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Role of Head and Cardiac Imaging, and Cardiac Stress Testing for Syncope

Syncope ◽

10.1007/978-3-030-44507-2_18 ◽

2020 ◽

pp. 221-225

Author(s):

Mohammed Ruzieh ◽

Blair P. Grubb

Keyword(s):

Cardiac Imaging ◽

Stress Testing ◽

Cardiac Stress ◽

Cardiac Stress Testing

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The Limited Utility of Routine Cardiac Stress Testing in Emergency Department Chest Pain Patients Younger Than 40 Years

Annals of Emergency Medicine ◽

10.1016/j.annemergmed.2009.01.006 ◽

2009 ◽

Vol 54 (1) ◽

pp. 12-16 ◽

Cited By ~ 45

Author(s):

Luke K. Hermann ◽

Scott D. Weingart ◽

W. Lane Duvall ◽

Milena J. Henzlova

Keyword(s):

Emergency Department ◽

Chest Pain ◽

Stress Testing ◽

Cardiac Stress ◽

Cardiac Stress Testing ◽

Pain Patients

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Blood pressure and risk of cognitive impairment. The role of vascular disease in neurodegeneration.

10.21203/rs.2.18666/v1 ◽

2019 ◽

Author(s):

Mar Carmona-Abellan ◽

Malwina Trzeciak ◽

Miriam Recio-Fernandez ◽

Beatriz Echeveste ◽

Laura Imaz ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cognitive Impairment ◽

Cognitive Decline ◽

Stress Testing ◽

Cardiovascular Response ◽

Stress Test ◽

Peak Exercise ◽

Cardiac Stress ◽

Cardiac Stress Testing

Abstract Background: Both cerebral vascular disorders and cognitive decline increase in incidence with age. The role of cerebral vascular disease and hemodynamic changes in the development of cognitive deficits is controversial. The objective of this study was to assess cardiovascular response during cardiac stress testing in neurologically asymptomatic individuals who developed cognitive impairment several years after the cardiac stress testing.Methods: This is a retrospective cohort study of patients who underwent cardiac stress testing between January 2001 and December 2010. Patients were followed up until May 2015 and we selected those who developed cognitive dysfunction including dementia, mild cognitive impairment and subjective cognitive decline, after the stress test. Heart rate and blood pressure both at rest and at peak exercise and the mean R-R interval at rest were recorded. For each patient who developed cognitive impairment, we selected one matched control who did not show cognitive decline by the end of the follow-up period.Results: From this cohort of 7224 patients, 371 developed cognitive impairment; of these, 186 (124 men) met the inclusion criteria and 186 of the other patients were selected as matched controls. During follow-up, cognitive impairment appeared 6.2 ± 4.7 years after the cardiac stress test. These patients who subsequently developed cognitive impairment had significantly lower at-rest systolic, diastolic and mean blood pressure than controls (p<0.05). Further, compared with controls, their maximum heart rate was significantly higher at peak exercise and both systolic and diastolic blood pressures increased significantly more during exercise. Conclusion: The results from this study suggest that differences in cardiovascular response to stress are present in the preclinical phase of cognitive decline, serving as a potential risk factor for cognitive impairment. These findings challenge the potential use of blood pressure and heart rate variability at rest and during cardiac stress assessment as a risk factor for cognitive impairment.

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