Abstract 15830: Elevated Resting Heart Rate is Associated With Impaired Quality of Life and Worse NYHA Functional Capacity in Patients With Chronic Heart Failure: Results From REALITY HF Study

Purpose: Resting heart rate (HR), health related quality of life (HQoL) and NYHA functional capacity are referred as important determinants of prognosis and targets of therapy in heart failure (HF). REALITY HF (Resting Heart Rate and Real Life Treatment Modality in Outpatients with Left Ventricular Systolic Dysfunction) study data were analyzed for the evaluation of any relationship of resting HR with HQoL assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ) and NYHA functional class. Methods: REALITY HF was a multicenter, prospective registry designed to evaluate HF patients’ characteristics and effects of treatment modalities on resting HR and enrolled 1057 patients (age 61±12 years) with LVEF <40%. 781 (74%) patients in sinus rhythm were included in this analysis. Patients were classified into 4 groups according to the quartiles of HR: Q1:<68 bpm (n=234), Q2:69-75 bpm (n=189), Q3:76-87 bpm (n=194) and Q4:>87 bpm (n=164). KCCQ was completed in a random sample of 320 (Q1:n=27, Q2:n=99, Q3:n=125, Q4:n=69) patients, in which higher scores show better patient’s health status. Results: During enrollment, 82% of patients were receiving ≥2 drugs including ACE[[Unable to Display Character: İ]]/ARB, beta blocker, aldosterone blocker, diuretic or digoxin. Resting HR was 76±14 bpm and 68% of patients had a resting HR ≥70 bpm. KCCQ overall summary score (OSC) was found to be 75.7±13.2 in those in Q1, 65.5±20.8 in Q2, 64.4±20.6 in Q3 and 58.3±21.2 in Q4 (p=0.004) and KCCQ clinical summary score (CSS) was 80.4±15.7 in those in Q1, 70.0±22.4 in Q2, 69.9±21.9 in Q3 and 63.8±23.3 in Q4 (p=0.016). Also, there was a significant negative correlation between resting HR and OSC (p=0.008) or CSS (p=0.031). The distribution of NYHA-I patients for Q1, Q2, Q3 and Q4 were 40.7%, 22.8%, 23.8% and 12.7%, NYHA-II patients-30.8%, 23.1%, 27.2% and 18.9%, NYHA-III patients-21.2%, 23.9%, 24.3% and 30.6% and NYHA-IV patients-22.7%, 34.1%, 22.7% and 20.5%, respectively (p<0.001). Also, resting HR were found to gradually and significantly increase across NYHA categories (72.8±12 bpm in NYHA-I, 76.1±13 bpm in NYHA-II, 80.2±15 bpm in NYHA-III and 78.9±16 bpm in NYHA-IV, p<0.001). Conclusions: These results suggest that elevated resting HR in HF patients is associated with impaired HQoL and worse NYHA functional capacity.

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Beneficial Effects of Testosterone Therapy on Functional Capacity, Cardiovascular Parameters, and Quality of Life in Patients with Congestive Heart Failure

BioMed Research International ◽

10.1155/2014/392432 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 22

Author(s):

Ahmad Mirdamadi ◽

Mohammad Garakyaraghi ◽

Ali Pourmoghaddas ◽

Alireza Bahmani ◽

Hamideh Mahmoudi ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Congestive Heart Failure ◽

Functional Capacity ◽

Controlled Trial ◽

Study Groups ◽

Left Ventricular ◽

Testosterone Therapy ◽

Double Blind

Background.According to the present evidences suggesting association between low testosterone level and prediction of reduced exercise capacity as well as poor clinical outcome in patients with heart failure, we sought to determine if testosterone therapy improves clinical and cardiovascular conditions as well as quality of life status in patients with stable chronic heart failure.Methods.A total of 50 male patients who suffered from congestive heart failure were recruited in a double-blind, placebo-controlled trial and randomized to receive an intramuscular (gluteal) long-acting androgen injection (1 mL of testosterone enanthate 250 mg/mL) once every four weeks for 12 weeks or receive intramuscular injections of saline (1 mL of 0.9% wt/vol NaCl) with the same protocol.Results.The changes in body weight, hemodynamic parameters, and left ventricular dimensional echocardiographic indices were all comparable between the two groups. Regarding changes in diastolic functional state and using Tei index, this parameter was significantly improved. Unlike the group received placebo, those who received testosterone had a significant increasing trend in 6-walk mean distance (6MWD) parameter within the study period (P=0.019). The discrepancy in the trends of changes in 6MWD between study groups remained significant after adjusting baseline variables (mean square = 243.262,Findex = 4.402, andP=0.045).Conclusion.Our study strengthens insights into the beneficial role of testosterone in improvement of functional capacity and quality of life in heart failure patients.

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Effects of a Higher Heart Rate on Quality of Life and Functional Capacity in Patients With Left Ventricular Diastolic Dysfunction

The American Journal of Cardiology ◽

10.1016/j.amjcard.2019.07.008 ◽

2019 ◽

Vol 124 (7) ◽

pp. 1069-1075 ◽

Cited By ~ 1

Author(s):

Kramer Wahlberg ◽

Maren E. Arnold ◽

Daniel Lustgarten ◽

Markus Meyer

Keyword(s):

Quality Of Life ◽

Heart Rate ◽

Diastolic Dysfunction ◽

Functional Capacity ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Ventricular Diastolic Dysfunction

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Resting Heart Rate and Real-Life Treatment Modalities in Outpatients with Left Ventricular Systolic Dysfunction (REALITY HF) study: A Multicenter, Prospective, Observational and National Registry

The Anatolian Journal of Cardiology ◽

10.14744/anatoljcardiol.2020.13247 ◽

2020 ◽

Author(s):

Yüksel Çavuşoğlu

Keyword(s):

Heart Rate ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Real Life ◽

National Registry ◽

Left Ventricular ◽

Treatment Modalities ◽

Resting Heart Rate ◽

Ventricular Systolic Dysfunction

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Impact of yoga and group exercise on quality of life for people living with heart failure

British Journal of Cardiac Nursing ◽

10.12968/bjca.2020.0053 ◽

2020 ◽

Vol 15 (10) ◽

pp. 1-12

Author(s):

Francesca Bingley

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Heart Rate ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Controlled Study ◽

Group Exercise ◽

Ventricular Ejection Fraction ◽

Randomised Controlled

Background/Aims There is a direct correlation between depression and anxiety, quality of life, and heart failure, therefore methods of empowering people with their rehabilitation are needed in the community for long-term health. This study aimed to discover the effects of yoga on quality of life for people with heart failure when used in conjunction with rehabilitation group exercise in the community. Methods Four databases were reviewed using key search terms to discover 67 potential articles. Once the inclusion/exclusion criteria were met, four appropriate articles were reviewed. Results Two systematic reviews, one randomised controlled study and one nonrandomised controlled study suggested that practicing yoga led to improvements in exercise capacity, depression, anxiety and fatigue, blood pressure, heart rate, heart rate variability, B-type natriuretic peptide, tei Index, autonomic nervous system function, and left ventricular ejection fraction. Quality of life was slightly improved. Conclusions There is promising evidence to support the use of yoga for physiological functions, and slight improvements to quality of life. Further research is needed to understand the best application of and effectiveness of yoga practices.

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Iron Deficiency: Impact on Functional Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction

Journal of Clinical Medicine ◽

10.3390/jcm9041199 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1199 ◽

Cited By ~ 1

Author(s):

Alex Alcaide-Aldeano ◽

Alberto Garay ◽

Lídia Alcoberro ◽

Santiago Jiménez-Marrero ◽

Sergi Yun ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Iron Deficiency ◽

Ejection Fraction ◽

Functional Capacity ◽

Iron Status ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Preserved Ejection Fraction

The effects of iron deficiency (ID) have been widely studied in heart failure (HF) with reduced ejection fraction. On the other hand, studies in HF with preserved ejection fraction (HFpEF) are few and have included small numbers of participants. The aim of this study was to assess the role that ID plays in functional capacity and quality of life (QoL) in HFpEF while comparing several iron-related biomarkers to be used as potential predictors. ID was defined as ferritin <100 ng/mL or transferrin saturation <20%. Submaximal exercise capacity, measured by the 6-min walking test (6MWT), and QoL, assessed by the Minnesotta Living with Heart Failure Questionnaire (MLHFQ), were compared between iron deficient patients and patients with normal iron status. A total of 447 HFpEF patients were included in the present cross-sectional study, and ID prevalence was 73%. Patients with ID performed worse in the 6MWT compared to patients with normal iron status (ID 271 ± 94 m vs. non-ID 310 ± 108 m, p < 0.01). They also scored higher in the MLHFQ, denoting worse QoL (ID 49 ± 22 vs. non-ID 43 ± 23, p = 0.01). Regarding iron metabolism biomarkers, serum soluble transferrin receptor (sTfR) was the strongest independent predictor of functional capacity (β = −63, p < 0.0001, R2 0.39) and QoL (β = 7.95, p < 0.0001, R2 0.14) in multivariate models. This study postulates that ID is associated with worse functional capacity and QoL in HFpEF as well, and that sTfR is the best iron-related biomarker to predict both. Our study also suggests that the effects of ID could differ among HFpEF patients by left ventricular ejection fraction.

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