Abstract P261: Associations of Left Ventricular Mass, Total Body Weight, and Fat-Free Mass With Body Mass Index: The Framingham Heart Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Philimon N Gona ◽  
Jane J Lee ◽  
Carol J Salton ◽  
Saadia Qazi ◽  
Christopher J O'Donnell ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Linear Trend ◽  
Left Ventricular ◽  
Fat Free Mass ◽  
Total Body Mass ◽  
Ventricular Mass ◽  
Cardiovascular Morbidity And Mortality ◽  
Total Body

Introduction: Increased left ventricular mass (LVM) predicts excess cardiovascular morbidity and mortality. LVM is often indexed to height (HT) or body surface area (BSA). HT-indexation ignores weight and thus obesity. The relationship of indexed LVM with weight, obesity, and adiposity is unclear. We investigated the association of LVM with total-body mass (TBM, i.e. weight) and fat-free mass (FFM), hypothesizing that LVM scales better to FFM than TBM. Methods: From the 1794 members of Framingham Offspring cohort who underwent cardiac magnetic resonance (CMR), we identified 845 (aged 65±9y) without any history of hypertension, myocardial infarction, heart failure, or CMR wall-motion abnormality. LVM was measured from cine bSSFP images and indexed to HT, BSA, TBM and FFM (by DEXA). Participants were stratified by sex and body mass index (BMI) category (NL=BMI 18.5 - 24.9; OW=25.0 - 29.9; OB=30.0+ kg/m 2 ). We used sex-specific ANCOVA to test for linear trend across BMI categories, and determined sex-specific Pearson correlation coefficients of LVM with BMI; both sets of analyses were adjusted for age and systolic blood pressure. Data are summarized as mean ± SD. Results: The Table shows that LVM and LVM/HT increase with greater BMI-category in both sexes. LVM/BSA was similar across BMI-categories, while LVM/TBM decreased. There was no linear trend across BMI-categories for LVM/FFM in either sex. On a continuous basis, LVM and LVM/HT were positively correlated with BMI in both sexes (r=0.20 to 0.35, p<0.001 for all); LVM/BSA was weakly inversely correlated with BMI in women only (r=-0.14, p=0.001) but not men (r=-0.08, p=0.18); LVM/TBM was inversely correlated with BMI (M: r=-0.39, W: r=-0.54; p<0.0001 both); LVM/FFM was not correlated with BMI in either sex (M: r=-0.05, p=0.38, W: r=0.08, p=0.055). Conclusion: LVM as a proportion of TBM (weight) actually decreases with greater BMI, while LVM/FFM is not associated with BMI. Whether LVM is better scaled to FFM vs HT, BSA or TBM for risk stratification purposes remains to be determined.

Left ventricular mass by echocardiographic measures in children and adolescents

2012 ◽  
Vol 23 (5) ◽  
pp. 727-737 ◽  
Author(s):  
Sudhir K. Mehta
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Surface Area ◽  
Left Ventricular Mass ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Cardiovascular Morbidity And Mortality

AbstractBackgroundRecent evidence in adults suggests that left ventricular mass measured as left ventricular mass/height1.7 predicts cardiovascular morbidity and mortality better than the two widely used indices, left ventricular mass/body surface area and left ventricular mass/height2.7. Standards of left ventricular mass/height1.7 have not been reported in children, for whom, owing to lack of significant cardiovascular morbidity and mortality, body mass index has traditionally been used as a potential cardiovascular risk factor.MethodsIn this retrospective study, 692 clinically normal children aged 1 day to 18 years underwent detailed echocardiographic assessment to assess whether any of the left ventricular mass indices – left ventricular mass/height1.7, left ventricular mass/body surface area, and left ventricular mass/height2.7 – are associated with obesity as measured by body mass index. Correlations, t-tests, and linear regressions were used for statistical testing.ResultsLeft ventricular mass/height1.7 was better correlated (R2 = 0.36) with body mass index than left ventricular mass/body surface area (R2 = 0.179) and left ventricular mass/height2.7 (R2 = 0.006), although all three dependent variables show a significant correlation (p < 0.035). In addition, a higher percentage of obese patients were noted to have elevated left ventricular mass as measured by left ventricular mass/height1.7 than by the other two methods.ConclusionsLeft ventricular mass/height1.7 is a reliable indicator of obesity-associated left ventricular hypertrophy. Left ventricular mass/height1.7 can be used conveniently during transitions from youth to adults for long-term follow-up. These findings support the importance of including left ventricular mass/height1.7 in future studies of cardiovascular risks and preventive strategies in children and adolescents.

scholarly journals Adiponectin correlates with body mass index and to a lesser extent with left ventricular mass in dialysis patients

2018 ◽  
Vol 25 (4) ◽  
pp. 501-511 ◽  
Author(s):  
Afrim Poniku ◽  
Gani Bajraktari ◽  
Shpend Elezi ◽  
Pranvera Ibrahimi ◽  
Michael Y. Henein
Keyword(s):  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Dialysis Patients ◽  
Ventricular Mass

Relationship of Left Ventricular Mass to Insulin Sensitivity and Body Mass Index in Healthy Individuals

2006 ◽  
Vol 61 (4) ◽  
pp. 398-406 ◽  
Author(s):  
Haksun EBINÇ ◽  
Fatma Ayerden EBINÇ ◽  
Zübeyde Nur ÖZKURT ◽  
Tolga DOGRU ◽  
Murat YILMAZ
Keyword(s):  
Body Mass Index ◽  
Insulin Sensitivity ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Healthy Individuals ◽  
Ventricular Mass ◽  
Relationship Of

scholarly journals Effect of haemodynamic and metabolic predictors on echocardiographic left ventricular mass in non-diabetic hypertensive patients

1970 ◽  
Vol 8 (2) ◽  
pp. 173-178
Author(s):  
N Gupta ◽  
P Karki ◽  
S Sharma ◽  
N Shrestha ◽  
P Acharya
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Stroke Volume ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Metabolic Factors ◽  
Hypertensive Patients ◽  
Ventricular Mass ◽  
Lv Mass

Background: Left ventricular hypertrophy is a forerunner of coronary heart disease, congestive cardiac failure, stroke and may also lead to sudden death. Estimation of left ventricular mass by echocardiography offers prognostic information better than the evaluation of traditional cardiovascular risk factors. Objective: The aim of this study was to determine the relative contributions of haemodynamic and metabolic factors affecting left ventricular mass in non-diabetic patients with essential hypertension. Material and methods: 100 non-diabetic hypertensive patients were taken. The association between age, gender, smoking, alcohol, height, weight, heart rate, clinic blood pressure, fasting blood glucose, lipid profile, haemoglobin, body mass index and stroke volume with LV mass was studied. Left ventricular mass was measured by using standard M-mode echocardiography measurement obtained by way of standard recommended by the American Society of Echocardiography. Results: Left ventricular mass was analyzed as a continuous variable. In males body mass index (r=.35, p<.004) and stroke volume(r=-.26, p<.039) were significantly correlated with LV mass. In females body weight was significantly related to left ventricular mass(r=.36, p<.02). The independent association between significant factors and left ventricular mass was assessed by stepwise multivariate logistic regression. Body mass index and systolic blood pressure came as independent determinants of left ventricular mass in all patients. A maximum of 13% of left ventricular mass variability could be explained by these two factors. Conclusion: In untreated patients with hypertension patient's body mass index and systolic blood pressure are independent predictors of left ventricular mass after adjustment for other haemodynamic and metabolic factors. They explain a maximum of 13% of left ventricular mass variability. More knowledge is needed about factors that may alter cardiac morphology in the evolution of hypertensive patients. Key words: Echocardiography; Haemodynamic; Metabolic Factors; Left Ventricular Mass; Non-diabetic; Hypertensive DOI: 10.3126/kumj.v8i2.3553 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 173-178

scholarly journals Anger Types: Heritability and Relation to Blood Pressure, Body Mass Index, and Left Ventricular Mass

2008 ◽  
Vol 10 (9) ◽  
pp. 700-706 ◽  
Author(s):  
Lillian Gleiberman ◽  
Tiffany A. Greenwood ◽  
Amy Luke ◽  
Maria C. Delgado ◽  
Alan B. Weder
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass
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