scholarly journals Effect of haemodynamic and metabolic predictors on echocardiographic left ventricular mass in non-diabetic hypertensive patients

1970 ◽  
Vol 8 (2) ◽  
pp. 173-178
Author(s):  
N Gupta ◽  
P Karki ◽  
S Sharma ◽  
N Shrestha ◽  
P Acharya
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Stroke Volume ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Metabolic Factors ◽  
Hypertensive Patients ◽  
Ventricular Mass ◽  
Lv Mass

Background: Left ventricular hypertrophy is a forerunner of coronary heart disease, congestive cardiac failure, stroke and may also lead to sudden death. Estimation of left ventricular mass by echocardiography offers prognostic information better than the evaluation of traditional cardiovascular risk factors. Objective: The aim of this study was to determine the relative contributions of haemodynamic and metabolic factors affecting left ventricular mass in non-diabetic patients with essential hypertension. Material and methods: 100 non-diabetic hypertensive patients were taken. The association between age, gender, smoking, alcohol, height, weight, heart rate, clinic blood pressure, fasting blood glucose, lipid profile, haemoglobin, body mass index and stroke volume with LV mass was studied. Left ventricular mass was measured by using standard M-mode echocardiography measurement obtained by way of standard recommended by the American Society of Echocardiography. Results: Left ventricular mass was analyzed as a continuous variable. In males body mass index (r=.35, p<.004) and stroke volume(r=-.26, p<.039) were significantly correlated with LV mass. In females body weight was significantly related to left ventricular mass(r=.36, p<.02). The independent association between significant factors and left ventricular mass was assessed by stepwise multivariate logistic regression. Body mass index and systolic blood pressure came as independent determinants of left ventricular mass in all patients. A maximum of 13% of left ventricular mass variability could be explained by these two factors. Conclusion: In untreated patients with hypertension patient's body mass index and systolic blood pressure are independent predictors of left ventricular mass after adjustment for other haemodynamic and metabolic factors. They explain a maximum of 13% of left ventricular mass variability. More knowledge is needed about factors that may alter cardiac morphology in the evolution of hypertensive patients. Key words: Echocardiography; Haemodynamic; Metabolic Factors; Left Ventricular Mass; Non-diabetic; Hypertensive DOI: 10.3126/kumj.v8i2.3553 Kathmandu University Medical Journal (2010), Vol. 8, No. 2, Issue 30, 173-178

scholarly journals Relationship between Plasma Aldosterone Levels and Left Ventricular Mass in Hypertensive Africans

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Adewole Adebiyi ◽  
Olubayo Akinosun ◽  
Chibuike Nwafor ◽  
Ayodele Falase
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Plasma Renin ◽  
Left Ventricular ◽  
Plasma Aldosterone ◽  
The Body ◽  
Ventricular Mass ◽  
Lv Mass

Background.Hypertension is the most common cardiovascular disease worldwide and is a major cause of morbidity and mortality. Studies have suggested that the activity of the renin-angiotensin-aldosterone system play a major role in the target organ damage such as left ventricular hypertrophy occuring in hypertension. We sought to determine the relationship between plasma aldosterone and left ventricular mass in untreated African hypertensives.Methods.We recruited 82 newly diagnosed and untreated hypertensives and 51 normal controls. Measurements obtained included echocardiographic LV mass index, plasma aldosterone and renin.Results.The hypertensive subjects had lower renin levels (21.03[6.974] versus 26.66[7.592] ng.mL−1,P=0.0013), higher LV mass index (52.56[14.483] versus 42.02[8.315] g.m−2.7P<0.0001) when compared with the controls. There were no univariate associations between LV mass index and plasma aldosterone (r=0.0179,P=0.57) and between LV mass index and plasma renin (r=0.0887,P=0.61). In a multivariate model involving LV mass index and age, sex, body mass index (BMI), plasma aldosterone, plasma renin and systolic blood pressure (SBP), only age (P=0.008), BMI (P=0.046), and SBP (P=0.001) were independently associated with the LV mass index.Conclusions. In this group of hypertensive Africans, there is no independent association of plasma aldosterone with LV mass. The height of the blood pressure, the body mass index and the age of the subjects determined the LV mass.

scholarly journals Anger Types: Heritability and Relation to Blood Pressure, Body Mass Index, and Left Ventricular Mass

2008 ◽  
Vol 10 (9) ◽  
pp. 700-706 ◽  
Author(s):  
Lillian Gleiberman ◽  
Tiffany A. Greenwood ◽  
Amy Luke ◽  
Maria C. Delgado ◽  
Alan B. Weder
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass

scholarly journals Life-Course Cumulative Burden of Body Mass Index and Blood Pressure on Progression of Left Ventricular Mass and Geometry in Midlife

2020 ◽  
Vol 126 (5) ◽  
pp. 633-643 ◽  
Author(s):  
Yinkun Yan ◽  
Shengxu Li ◽  
Yajun Guo ◽  
Camilo Fernandez ◽  
Lydia Bazzano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Life Course ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass

Relationship of Systolic Blood Pressure and Body Mass Index With Left Ventricular Mass and Mass Index in Adolescents

Angiology ◽  
2015 ◽  
Vol 67 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Cengiz Ozturk ◽  
Mustafa Aparci ◽  
Mehmet Karaduman ◽  
Sevket Balta ◽  
Turgay Çelik ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Systolic Blood Pressure ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Relationship Of

scholarly journals Body Mass Index and Blood Pressure Influences on Left Ventricular Mass and Geometry in African Americans

Hypertension ◽  
2004 ◽  
Vol 44 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Ervin Fox ◽  
Herman Taylor ◽  
Michael Andrew ◽  
Hui Han ◽  
Emad Mohamed ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
African Americans ◽  
Left Ventricular Mass ◽  
Body Mass ◽  
Left Ventricular ◽  
Ventricular Mass

Abstract 432: Race Differences in the Relationship between Urinary ET-1 and BP-related Target Organ Damage in Youth

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Gregory A Harshfield ◽  
Gregory A Harshfield ◽  
Jennifer Pollock ◽  
David Pollock
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Target Organ Damage ◽  
Albumin Excretion Rate ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Related Target ◽  
Ventricular Mass ◽  
Lv Mass

The overall goal of this study was to determine race/ethnic differences in the associations between renal ET-1 and indices of blood pressure-related target organ damage in healthy adolescents. The subjects ranged in age between 15-19 years, had no history of any disease, and were not on any prescription medications. The 92 subjects consisted of 48 Caucasians (CA) and 44 African-Americans (AA). The two groups were similar with respect to height, weight, body mass index, blood pressure, ET-1), albumin excretion rate (AER), and left ventricular mass). Results: The CA’s were slightly older 17±1 v 16±1 (p=.02). The protocol was preceded by a 3 day self-selected sodium controlled diet of 250 mEq/day day which the subject picked up each day. The test day began with an echocardiogram for the assessment of left ventricular mass. Next, the subjects were seated for 60 minutes of rest during which the subjects consumed 200 ml of water. This was followed by the collection of a urine sample for the measurement of ET-1 and AER. Overall, ET-1 excretion was correlated with AER (r=.278), LV mass/ht 2.7 (r=.341), and systolic blood pressure (SBP; r=.365; p=.01 for each). The significant overall correlations were the result of significant correlations in AAs for AER (r=.344; p=.05), LV mass/ht 2.7 (r=.520; p=.01), and SBP (r=.645; p=.01) which were not apparent in CA’s. These findings suggest urinary ET-1 contributes to the development of BP-related target organ damage in AA youths prior to the development of increases in blood pressure.

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