Abstract MP27: Changes In Cardiac Structure And Function Over 25 Years Are Associated With Lower Midlife Cognition: The Cardia Study

Background: Cardiovascular risk factors are associated with worse cognition, yet much less is known about the association of cardiac structure and function and decline over time with cognitive function, even as early as midlife. Method: We included 2256 subjects from the CARDIA (Coronary Artery Risk Development in Young Adults) study (60% women, 44% black). Echocardiograms were repeated at Years 5, 25, 30 (mean age 30, 50, 55 years, respectively) to assess left ventricular (LV) mass (LVM); LV systolic function with LV ejection fraction (LVEF); LV diastolic function with left atrial volume (LAV) and early peak mitral velocity (E)/early peak mitral annular velocity (e’) ratio. Five cognitive domains were assessed at Year 30: verbal memory, verbal fluency, processing speed, executive function, and global cognition. We investigated the association of (1) 25-year change and (2) Year 25 cardiac structure and function on midlife cognition using linear regressions. Results: Over 25 years, LVM and LAV increased with mean change (SD) of 5.7 g/m 2 (21.7) and 9.6 mL/m 2 (7.4) while LVEF decreased by mean (SD) change of 1.5% (9.0). Greater 25-year increase in LVM was associated with lower global cognition, processing speed, executive function, verbal memory, and verbal fluency. Similarly, greater 25-year increase in LAV was associated with lower cognition on most cognitive domains. Adjustment for (1) demographics, education and (2) hypertension, diabetes, smoking did not notably change the results. 25-year decrease in LVEF was not associated with cognition. In addition, higher Year 25 LVM, LAV and E/e’ ratio were significantly associated with worse cognition on most cognitive domains. Conclusion: Midlife altered cardiac structure and adverse changes from early to middle adulthood are associated with lower midlife cognition. Moreover, LV diastolic but not systolic dysfunction is linked to lower cognition. Our results provide novel information linking early to midlife cardiac structure and function to cognition.

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Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Cardiac Structure and Function at Midlife: The CARDIA Study

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.687054 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zhenyu Xiong ◽

Peihan Xie ◽

Jiaying Li ◽

Zhi-chong Chen ◽

Yifen Lin ◽

...

Keyword(s):

Young Adulthood ◽

Fasting Glucose ◽

Glycemic Variability ◽

Glucose Variability ◽

Left Ventricular ◽

Structure And Function ◽

Cardiac Structure ◽

Early Peak ◽

Cardiac Structure And Function ◽

And Function

Glycemic variability was found associated with left ventricular structure and function in type 2 diabetes. But it is still unclear that whether the greater visit-to-visit fasting glucose (FG) variability in young adulthood among the community population is associated with cardiac function alteration and cardiac remodeling at midlife. The community-based prospective cohort study of Coronary Artery Risk in Young Adult (CARDIA) recruited young participants at the baseline age of 18–30 years during the period of 1985–1986 (Year 0). FG was measured at Year 0, 2, 10, 15, 20, and 25. The echocardiographic evaluation of cardiac structure and function was conducted at year 25. A total of 2,600 young adults mean (SD) aged at 24.9 years (3.6) of which 57.3% were women and 46.7% were African Americans had been included in the study. After multivariable adjusted, higher SD of mean FG (SDFG) is associated with lower early peak diastolic septal mitral annular velocity (e') (β [SE], −0.214 [0.080], P < 0.01) and higher E/e' (β [SE], 0.307 [0.094], P < 0.01), and higher coefficient of variation of the mean FG (CVFG) is also associated with lower e' (β [SE], −0.141[0.066], P < 0.05) and higher E/e' (β [SE], 0.204 [0.078], P < 0.01). The higher average real variation of mean FG (ARVFG) is associated with higher E/e' (β [SE], 0.178 [0.085], P < 0.05) and higher left ventricular mass index (LVMI) (β [SE], 1.240 [0.618], P < 0.05). The higher FG variability in young adulthood is associated with the subclinical change of left ventricular (LV) diastolic function at midlife.

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Relation of Impaired Glucose Tolerance to Cardiac Structure and Function: The Strong Heart Study

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)88289-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 525A-526A

Author(s):

A Ilercil

Keyword(s):

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Structure And Function ◽

Cardiac Structure ◽

Strong Heart Study ◽

Heart Study ◽

Cardiac Structure And Function ◽

And Function

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Faculty Opinions recommendation of Cardiac structure and function in heart failure with preserved ejection fraction: baseline findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718180959.793489610 ◽

2014 ◽

Author(s):

Chim Lang

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Cardiac Function ◽

Structure And Function ◽

Cardiac Structure ◽

Preserved Ejection Fraction ◽

Aldosterone Antagonist ◽

Echocardiographic Study ◽

Cardiac Structure And Function ◽

And Function

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Impact of the severity of end-stage liver disease in cardiac structure and function

Annals of Hepatology ◽

10.1016/s1665-2681(19)31389-4 ◽

2013 ◽

Vol 12 (1) ◽

pp. 85-91 ◽

Cited By ~ 18

Author(s):

Odilson Marcos Silvestre ◽

Fernando Bacal ◽

Danusa de Souza Ramos ◽

Jose L. Andrade ◽

Meive Furtado ◽

...

Keyword(s):

Liver Disease ◽

Structure And Function ◽

Cardiac Structure ◽

End Stage Liver Disease ◽

Cardiac Structure And Function ◽

End Stage ◽

And Function

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Development of a semi-automated segmentation tool for high frequency ultrasound image analysis of mouse echocardiograms

Scientific Reports ◽

10.1038/s41598-021-85971-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kristi Powers ◽

Raymond Chang ◽

Justin Torello ◽

Rhonda Silva ◽

Yannick Cadoret ◽

...

Keyword(s):

Image Analysis ◽

Automated Analysis ◽

Structure And Function ◽

Ultrasound Images ◽

Cardiac Structure ◽

Short Axis ◽

Pixel Intensity ◽

Cardiac Structure And Function ◽

And Function

AbstractEchocardiography is a widely used and clinically translatable imaging modality for the evaluation of cardiac structure and function in preclinical drug discovery and development. Echocardiograms are among the first in vivo diagnostic tools utilized to evaluate the heart due to its relatively low cost, high throughput acquisition, and non-invasive nature; however lengthy manual image analysis, intra- and inter-operator variability, and subjective image analysis presents a challenge for reproducible data generation in preclinical research. To combat the image-processing bottleneck and address both variability and reproducibly challenges, we developed a semi-automated analysis algorithm workflow to analyze long- and short-axis murine left ventricle (LV) ultrasound images. The long-axis B-mode algorithm executes a script protocol that is trained using a reference library of 322 manually segmented LV ultrasound images. The short-axis script was engineered to analyze M-mode ultrasound images in a semi-automated fashion using a pixel intensity evaluation approach, allowing analysts to place two seed-points to triangulate the local maxima of LV wall boundary annotations. Blinded operator evaluation of the semi-automated analysis tool was performed and compared to the current manual segmentation methodology for testing inter- and intra-operator reproducibility at baseline and after a pharmacologic challenge. Comparisons between manual and semi-automatic derivation of LV ejection fraction resulted in a relative difference of 1% for long-axis (B-mode) images and 2.7% for short-axis (M-mode) images. Our semi-automatic workflow approach reduces image analysis time and subjective bias, as well as decreases inter- and intra-operator variability, thereby enhancing throughput and improving data quality for pre-clinical in vivo studies that incorporate cardiac structure and function endpoints.

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The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

Scientific Reports ◽

10.1038/s41598-021-84233-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Qing Zou ◽

Rong Xu ◽

Xiao Li ◽

Hua-yan Xu ◽

Zhi-gang Yang ◽

...

Keyword(s):

Mitral Regurgitation ◽

Nyha Class ◽

Left Ventricular ◽

Structure And Function ◽

Left Ventricular Geometry ◽

Cardiac Structure ◽

Left Ventricular Noncompaction ◽

Ventricular Noncompaction ◽

Cardiac Structure And Function ◽

And Function

AbstractThis study evaluated the effects of mitral regurgitation (MR) on cardiac structure and function in left ventricular noncompaction (LVNC) patients. The clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with noncompaction or hypertrabeculation from three institutes were retrospectively included. We analyzed the difference in left ventricular geometry, cardiac function between LVNC patients with and without MR. The results showed that patients with MR had a worse New York Heart Association (NYHA) class and a higher incidence of arrhythmia (P < 0.05). MR occurred in 48.2% of LVNC patients. Compared to LVNC patients without MR, the two-dimensional sphericity index, maximum/minimum end-diastolic ratio and longitudinal shortening in LVNC patients with MR were lower (P < 0.05), and the peak longitudinal strain (PLS) of the global and segmental myocardium were obviously reduced (P < 0.05). No significant difference was found in strain in LVNC patients with different degree of MR; end diastolic volume, end systolic volume, and global PLS were statistically associated with MR and NYHA class (P < 0.05), but the non-compacted to compacted myocardium ratio had no significant correlation with them. In conclusion, the presence of MR is common in LVNC patients. LVNC patients with MR feature more severe morphological and functional changes. Hypertrabeculation is not an important factor affecting structure and function at the heart failure stage.

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Differences between diabetic and non-diabetic nephropathy patients in cardiac structure and function at the beginning of hemodialysis and their impact on the prediction of mortality

Journal of International Medical Research ◽

10.1177/0300060521997588 ◽

2021 ◽

Vol 49 (3) ◽

pp. 030006052199758

Author(s):

Chao Tang ◽

Han Ouyang ◽

Jian Huang ◽

Jing Zhu ◽

Xiaosong Gu

Keyword(s):

Diabetic Nephropathy ◽

Diastolic Dysfunction ◽

Peak Velocity ◽

Structure And Function ◽

Cardiac Valve ◽

Cardiac Structure ◽

Prediction Of Mortality ◽

Cardiac Structure And Function ◽

Lv Diastolic Dysfunction ◽

And Function

Objectives To characterize differences in cardiac structure and function in hemodialysis (HD) patients with diabetic nephropathy (DN) and in those without using echocardiography and to determine their impact on the prediction of mortality using echocardiographic parameters. Methods Clinical, laboratory, and echocardiographic data were collected from patients commencing HD. Results Compared with those without DN, patients with DN had lower peak velocity of the early diastolic wave (e′), larger left atria, and higher peak early diastolic velocity (E)/e′ and peak velocity of tricuspid regurgitation (TR). In addition, a larger proportion of DN patients had a combination of left ventricular (LV) diastolic dysfunction, cardiac valve calcification, moderate-to-severe cardiac valve regurgitation (CVR), and at least moderate pericardial effusion (PE). After accounting for age, sex, smoking, hypertension, hemoglobin, and albumin, DN was responsible for e′ < 10 cm/s, E/e′ >13 m/s, TR >2.8 m/s, LV diastolic dysfunction, CVR, and PE. LV diastolic dysfunction and E/e′ >13 were the most useful predictors of mortality in patients with DN. Conclusions Patients with DN who undergo HD tend to have worse LV diastolic function and are more likely to have heart valve problems. LV diastolic dysfunction and E/e′ are predictors of death in DN patients.

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