scholarly journals Growth-Differentiation Factor-15 for Long-Term Risk Prediction in Patients Stabilized After an Episode of Non–ST-Segment–Elevation Acute Coronary Syndrome

2010 ◽  
Vol 3 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Kai M. Eggers ◽  
Tibor Kempf ◽  
Bo Lagerqvist ◽  
Bertil Lindahl ◽  
Sylvia Olofsson ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Prediction ◽  
Growth Differentiation Factor 15 ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
Differentiation Factor ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

Predictors of long-term use of evidence-based therapies after non-ST-segment elevation acute coronary syndrome. The S-Témoin survey

2009 ◽  
Vol 133 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Nicolas Danchin ◽  
François Diévart ◽  
Jean-François Thébaut ◽  
Olivier Grenier ◽  
Esvet Mihci ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Evidence Based ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
Elevation Acute Coronary Syndrome

scholarly journals Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Alberto Dominguez-Rodriguez ◽  
Pedro Abreu-Gonzalez ◽  
Idaira F. Hernandez-Baldomero ◽  
Pablo Avanzas ◽  
Francisco Bosa-Ojeda
Keyword(s):  
Acute Coronary Syndrome ◽  
Rate Of Change ◽  
C Reactive Protein ◽  
Cardiac Events ◽  
Growth Differentiation Factor 15 ◽  
St Segment Elevation ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
Differentiation Factor ◽  
Elevation Acute Coronary Syndrome

Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk. The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation occurring over time. The aims of our study are: (a) to describe the changes in hsCRP and GDF-15 levels over a period of time and after an episode of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and (b) to examine whether the rate of change in hsCRP and GDF-15 after the acute event is associated with long-term major cardiovascular adverse events (MACE). Two hundred and Fifty five NSTE-ACS patients were included in the study. We measured hsCRP and GDF-15 concentrations, at admission and again 36 months after admission (end of the follow-up period). The present study shows that the change of hsCRP levels, measured after 36 months, does not predict MACE in NSTEACS-patients. However, the level of GDF-15 measured, after 36 months, was a stronger predictor of MACE, in comparison to the acute unstable phase.

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