scholarly journals Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

2012 ◽  
Vol 5 (6) ◽  
pp. 812-818 ◽  
Author(s):  
Stewart H. Lecker ◽  
Alexandra Zavin ◽  
Peirang Cao ◽  
Ross Arena ◽  
Kelly Allsup ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Exercise Performance ◽  
Patients With Heart Failure

scholarly journals Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure

1997 ◽  
Vol 82 (1) ◽  
pp. 257-261 ◽  
Author(s):  
Chim C. Lang ◽  
Don B. Chomsky ◽  
Glenn Rayos ◽  
T. K. Yeoh ◽  
John R. Wilson
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Exercise Performance ◽  
Skeletal Muscle Mass ◽  
Maximal Exercise ◽  
Skeletal Muscle Atrophy ◽  
Patients With Heart Failure ◽  
Ambulatory Patients ◽  
Maximal Exercise Capacity

Lang, Chim C., Don B. Chomsky, Glenn Rayos, T. K. Yeoh, and John R. Wilson. Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure. J. Appl. Physiol. 82(1): 257–261, 1997.—The purpose of this study was to determine whether skeletal muscle atrophy limits the maximal exercise capacity of stable ambulatory patients with heart failure. Body composition and maximal exercise capacity were measured in 100 stable ambulatory patients with heart failure. Body composition was assessed by using dual-energy X-ray absorption. Peak exercise oxygen consumption (V˙o 2 peak) and the anaerobic threshold were measured by using a Naughton treadmill protocol and a Medical Graphics CardioO2 System.V˙o 2 peak averaged 13.4 ± 3.3 ml ⋅ min−1 ⋅ kg−1or 43 ± 12% of normal. Lean body mass averaged 52.9 ± 10.5 kg and leg lean mass 16.5 ± 3.6 kg. Leg lean mass correlated linearly with V˙o 2 peak( r= 0.68, P < 0.01), suggesting that exercise performance is influenced by skeletal muscle mass. However, lean body mass was comparable to levels noted in 1,584 normal control subjects, suggesting no decrease in muscle mass. Leg muscle mass was comparable to levels noted in 34 normal control subjects, further supporting this conclusion. These findings suggest that exercise intolerance in stable ambulatory patients with heart failure is not due to skeletal muscle atrophy.

MIOPATIA MUSCULAR ESQUELÉTICA INDUZIDA PELA INSUFICIÊNCIA CARDÍACA DE ETIOLOGIA HIPERTENSIVA: PAPEL TERAPÊUTICO DO TREINAMENTO FÍSICO AERÓBIOHYPERTENSIVE HEART FAILURE-INDUCED SKELETAL MUSCLE MYOPATHY: THERAPEUTIC ROLE OF AEROBIC EXERCISE TRAININGRESUMOA insuficiência cardíaca (IC) é a via final comum da maioria das doenças que acometem o coração. Entre os fatores de risco conhecidos, a hipertensão arterial (HA) é a doença mais frequentemente associada à IC. Caracterizada pela intolerância ao exercício, a IC promove disfunção cardíaca e alterações intrínsecas musculares envolvidas na redução da capacidade física. Várias anormalidades do músculo esquelético têm sido descritas em pacientes e animais com IC, incluindo atrofia, fibrose, mudança na composição dos tipos de fibras, rarefação microvascular e reduzida capacidade de oxidação. Por outro lado, o treinamento físico aeróbio (TFA) vem sendo utilizado como uma importante terapia não farmacológica para a prevenção e o tratamento da IC; em parte, por melhorar a função endotelial e a perfusão coronária, diminuir a resistência vascular periférica e induzir o remodelamento das células musculares cardíacas e esqueléticas, levando ao aumento da captação de oxigênio e resistência à fadiga. Os mecanismos e vias de sinalização intracelular envolvidas nas anormali

2020 ◽  
Vol 30 (2) ◽  
pp. 239-247
Author(s):  
Bruno Rocha de Avila Pelozin ◽  
◽  
Larissa Ferreira-Santos ◽  
Luis Felipe Rodrigues ◽  
Edilamar Menezes de Oliveira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Therapeutic Role ◽  
Insuficiencia Cardiaca

Effect of Sympathoinhibition on Exercise Performance in Patients With Heart Failure

Circulation ◽  
1997 ◽  
Vol 96 (1) ◽  
pp. 238-245 ◽  
Author(s):  
Chim C. Lang ◽  
Glenn H. Rayos ◽  
Don B. Chomsky ◽  
Alastair J. J. Wood ◽  
John R. Wilson
Keyword(s):  
Heart Failure ◽  
Exercise Performance ◽  
Patients With Heart Failure

Soothing the sleeping giant: improving skeletal muscle oxygen kinetics and exercise intolerance in HFpEF

2015 ◽  
Vol 119 (6) ◽  
pp. 734-738 ◽  
Author(s):  
Satyam Sarma ◽  
Benjamin D. Levine
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Functional Capacity ◽  
Oxidative Capacity ◽  
Exercise Intolerance ◽  
Aerobic Performance ◽  
Muscle Oxygen ◽  
Oxygen Kinetics ◽  
Patients With Heart Failure

Patients with heart failure with preserved ejection fraction (HFpEF) have similar degrees of exercise intolerance and dyspnea as patients with heart failure with reduced EF (HFrEF). The underlying pathophysiology leading to impaired exertional ability in the HFpEF syndrome is not completely understood, and a growing body of evidence suggests “peripheral,” i.e., noncardiac, factors may play an important role. Changes in skeletal muscle function (decreased muscle mass, capillary density, mitochondrial volume, and phosphorylative capacity) are common findings in HFrEF. While cardiac failure and decreased cardiac reserve account for a large proportion of the decline in oxygen consumption in HFrEF, impaired oxygen diffusion and decreased skeletal muscle oxidative capacity can also hinder aerobic performance, functional capacity and oxygen consumption (V̇o2) kinetics. The impact of skeletal muscle dysfunction and abnormal oxidative capacity may be even more pronounced in HFpEF, a disease predominantly affecting the elderly and women, two demographic groups with a high prevalence of sarcopenia. In this review, we 1) describe the basic concepts of skeletal muscle oxygen kinetics and 2) evaluate evidence suggesting limitations in aerobic performance and functional capacity in HFpEF subjects may, in part, be due to alterations in skeletal muscle oxygen delivery and utilization. Improving oxygen kinetics with specific training regimens may improve exercise efficiency and reduce the tremendous burden imposed by skeletal muscle upon the cardiovascular system.

scholarly journals Effect of increased inspired oxygen on exercise performance in patients with heart failure and normal ejection fraction

2018 ◽  
Vol 268 ◽  
pp. 166-169 ◽  
Author(s):  
Parin Shah ◽  
Pierpaolo Pellicori ◽  
Stella Rimmer ◽  
Alan S. Rigby ◽  
Andrew L. Clark
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Exercise Performance ◽  
Normal Ejection Fraction ◽  
Patients With Heart Failure ◽  
Inspired Oxygen

scholarly journals Metabolomic Analysis Reveals New Insights Towards Understanding Skeletal Muscle Mass and Exercise Capacity in Patients with Heart Failure

2015 ◽  
Vol 21 (10) ◽  
pp. S195 ◽  
Author(s):  
Masaya Tsuda ◽  
Shintaro Kinugawa ◽  
Arata Fukushima ◽  
Shingo Takada ◽  
Takashi Yokota ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Exercise Capacity ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Metabolomic Analysis ◽  
Patients With Heart Failure

scholarly journals Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure

2020 ◽  
Vol 76 (1) ◽  
pp. 109-114
Author(s):  
Ippei Nakano ◽  
Masaya Tsuda ◽  
Shintaro Kinugawa ◽  
Arata Fukushima ◽  
Naoya Kakutani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Muscle Wasting ◽  
Loop Diuretic ◽  
Skeletal Muscle Wasting ◽  
Patients With Heart Failure

Skeletal muscle hypoperfusion during recovery from maximal supine bicycle exercise in patients with heart failure

1996 ◽  
Vol 78 (7) ◽  
pp. 841-844 ◽  
Author(s):  
Tsutomu Sumimoto ◽  
Mutsuhito Kaida ◽  
Fumio Yuasa ◽  
Toshihiko Hattori ◽  
Toshimitsu Jikuhara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Bicycle Exercise ◽  
Patients With Heart Failure
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