Abstract P348: Prognostic Value of Exercise Capacity in Patients With Diabetes Mellitus

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Waqas T Qureshi ◽  
Mohammad Zaidan ◽  
Mohammad Alqarqaz ◽  
David Lanfear ◽  
Fatima Khalid ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Exercise Capacity ◽  
Prognostic Value ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Social Security Death Index ◽  
Insulin Dependent

Background: Exercise capacity has been shown to predict outcomes in the general population. However, the prognostic value of Exercise capacity in patients with insulin dependent diabetes mellitus (IDDM) and non insulin dependent diabetes mellitus (NIDDM) has not been extensively evaluated. Methods: We included 10768 consecutive diabetic patients (3600 (33%) IDDM and 7168 NIDDM (67%)) who underwent exercise testing between 1991 and 2008. Baseline characteristics and exercise data were collected prospectively at the time of testing including Metabolic Equivalents (METS). The primary endpoint is all cause mortality confirmed by the social security death index. Results: Patents with IDDM were older, more often females (46% vs. 41%) with higher prevalence of hypertension (83% vs. 77%) and prior coronary disease (21% vs. 17%). Patients with NIDDM achieved more than 10 METS more often (36% vs. 30%, p<0.0001). After a median follow-up duration of 6.4 years (Range 1-18 years), 2143 patients (20%) died. Kaplan Meier survival curves are shown below. Using Multivariable Cox Hazard Proportional Analysis, IDDM (Hazard ratio 1.45, 95% CI 1.3 -1.6, p<0.0001 (in comaprison to NIDDM)) and METS achieved (HR 0.82, 95% CI 0.80-0.83, p<0.0001 per METS achieved) were associated with decreased survival. Conclusions: In this large cohort of diabetic patients, decreased Exercise capacity is independently associated with decreased survival over long follow-up duration.

Hepatic drug metabolism is increased in poorly controlled insulin-dependent diabetes mellitus

1990 ◽  
Vol 123 (5) ◽  
pp. 550-556 ◽  
Author(s):  
Steven Goldstein ◽  
Anna Simpson ◽  
Paul Saenger
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Diabetic Control ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Insulin Dependent ◽  
Cytochrome P 450

Abstract. In addition to increased glycosylation of hemoglobin, abnormalities of other heme proteins such as cytochrome P-450 might also occur in patients with insulin-dependent diabetes mellitus. Antipyrine is a useful marker drug for cytochrome P-450 dependent hepatic drug metabolism. Antipyrine kinetics and urinary excretion of antipyrine metabolites were measured in 14 patients with insulin-dependent diabetes mellitus in poor metabolic control. Improvement in diabetic control in 9 patients, as measured by more normal HbA1 values, led to normalization of plasma antipyrine half-time (t½) and metabolism: the mean antipyrine t½ slowed from 4.7±0.2 (sem) initially to 7.8±0.3 h in these 9 patients and was thus nearly identical to that of normal subjects 8.6±1.0. Antipyrine plasma clearance improved in the 9 diabetic patients whose diabetic control improved. The apparent volume of distribution was normal on both occasions in the diabetic patients. These findings provide a new argument for tight metabolic control in patients with insulin-dependent diabetes mellitus.

scholarly journals FTIR Spectroscopic Investigation of Mineral Structure of Streptozotocin Induced Diabetic Rat Femur and Tibia

2003 ◽  
Vol 17 (2-3) ◽  
pp. 627-633 ◽  
Author(s):  
Handan Boyar ◽  
Belma Turan ◽  
Feride Severcan
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Rat ◽  
Carbonate Content ◽  
Diabetic Patients ◽  
Type I ◽  
Mineral Density ◽  
Insulin Dependent

Diabetes mellitus (DM) can be accepted as a heterogenous multi organ disorder that can affect various systems of the human body. Disorders include retinopathy, neuropathy, cardiomyopathy, musculoskeletal abnormalities such as diminished bone formation and bone healing retardation. Low bone mineral density is often mentioned as a complication for patients with insulin dependent diabetes mellitus (type I DM). Streptozotocin (STZ) induced diabetic rats are good models for investigation of the complications of insulin dependent diabetes. In the present study, the effects of STZ induced diabetes on the mineral environment of rat bones namely femur and tibia were studied by Fourier transform infrared (FTIR) spectroscopic technique. The results revealed that mineral crystal sizes increased and carbonate content decreased for diabetic femur and tibia. These changes can be due to the formation of osteoporosis which is widely seen in diabetic patients.

Celiac disease and type I (Insulin-Dependent) diabetes mellitus in childhood: Follow-up study

1996 ◽  
Vol 10 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Renata Lorini ◽  
M. Serenella Scotta ◽  
Luigia Cortona ◽  
M. Antonietta Avanzini ◽  
Letizia Vitali ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Celiac Disease ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Follow Up Study ◽  
Insulin Dependent

Islet cell transplantation for insulin-dependent diabetes mellitus: perspectives from the present and prospects for the future

2000 ◽  
Vol 2 (6) ◽  
pp. 1-28 ◽  
Author(s):  
Derek W.R. Gray ◽  
Nicolas Titus ◽  
Lionel Badet
Keyword(s):  
Diabetes Mellitus ◽  
Immune Modulation ◽  
Insulin Dependent Diabetes Mellitus ◽  
Human Islet ◽  
Insulin Dependent Diabetes ◽  
Current Status ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Islet Cell Transplantation ◽  
Insulin Dependent

The long-term complications of insulin-dependent diabetes mellitus have become a major health care problem, and it is now clear that they arise from inadequate homeostatic control of blood glucose by injected replacement insulin. Transplantation of pancreatic islets is arguably the most logical approach to restoring metabolic homeostasis in people with diabetes. This review looks at the current status of human islet transplantation and the problems that remain. These include: (1) the limited supply of human islet tissue available for transplantation; (2) the adverse effects of current immunosuppressive protocols on diabetic patients; (3) the problems of primary nonfunction of the transplanted islets; (4) the rejection of islets; and (5) the recurrence of autoimmune diabetic disease. Some of the approaches that might solve these problems are then examined: (1) immune modulation to reduce or prevent immune attack by the recipient's immune system; (2) immunoisolation to prevent recognition of the islet graft; (3) induction of tolerance; (4) xenotransplantation using islets derived from animals; and (5) gene therapy.

Assessing Daily Problems with Diabetes: A Subject-Oriented Approach to Compliance

1995 ◽  
Vol 76 (2) ◽  
pp. 515-521 ◽  
Author(s):  
Gabriele Duran ◽  
Peter Herschbach ◽  
Sabine Waadt ◽  
Friedrich Strian ◽  
Angela Zettler
Keyword(s):  
Diabetes Mellitus ◽  
Psychosocial Stress ◽  
Discriminant Validity ◽  
Reliability And Validity ◽  
Insulin Dependent Diabetes Mellitus ◽  
Self Report ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Insulin Dependent

The reliability, construct validity, and discriminant validity of a new self-report questionnaire, the Questionnaire on Stress in Diabetic Patients, were assessed in a sample of 617 patients with insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus. The 90-item inventory is designed to assess psychosocial stress associated with problems in daily living with diabetes. One of the intended uses is to identify psychosocial factors hampering patient compliance with the necessary treatment regimen. Values of Cronbach alpha ranged from 0.63 to 0.88. The results provide initial evidence for the reliability and validity of the instrument.

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