scholarly journals Histone Deacetylase 7 Silencing Alters Endothelial Cell Migration, a Key Step in Angiogenesis

2007 ◽  
Vol 101 (12) ◽  
pp. 1237-1246 ◽  
Author(s):  
Denis Mottet ◽  
Akeila Bellahcène ◽  
Sophie Pirotte ◽  
David Waltregny ◽  
Christophe Deroanne ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Histone Deacetylase ◽  
Endothelial Cell Migration

scholarly journals The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis

Blood ◽  
2012 ◽  
Vol 119 (3) ◽  
pp. 894-903 ◽  
Author(s):  
Graeme M. Birdsey ◽  
Nicola H. Dryden ◽  
Aarti V. Shah ◽  
Rebecca Hannah ◽  
Matthew D. Hall ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Histone Deacetylase ◽  
Transcriptome Profiling ◽  
Endothelial Cell Migration ◽  
Histone Deacetylase 6 ◽  
Tubulin Acetylation

Abstract The endothelial ETS transcription factor Erg plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates endothelial cell (EC) migration. Transcriptome profiling of Erg-deficient ECs identified ∼ 80 genes involved in cell migration as candidate Erg targets, including many regulators of Rho- GTPases. Inhibition of Erg expression in HUVECs resulted in decreased migration in vitro, while Erg overexpression using adenovirus caused increased migra-tion. Live-cell imaging of Erg-deficient HUVECs showed a reduction in lamellipodia, in line with decreased motility. Both actin and tubulin cytoskeletons were disrupted in Erg-deficient ECs, with a dramatic increase in tubulin acetylation. Among the most significant microarray hits was the cytosolic histone deacetylase 6 (HDAC6), a regulator of cell migration. Chromatin immunoprecipitation (ChIP) and transactivation studies demonstrated that Erg regulates HDAC6 expression. Rescue experiments confirmed that HDAC6 mediates the Erg-dependent regulation of tubulin acetylation and actin localization. In vivo, inhibition of Erg expression in angiogenic ECs resulted in decreased HDAC6 expression with increased tubulin acetylation. Thus, we have identified a novel function for the transcription factor Erg in regulating HDAC6 and multiple pathways essential for EC migration and angiogenesis.

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide

2008 ◽  
Vol 44 (13) ◽  
pp. 1914-1921 ◽  
Author(s):  
Pedro M. Lacal ◽  
Veronica Morea ◽  
Federica Ruffini ◽  
Angela Orecchia ◽  
Annalisa S. Dorio ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation

2005 ◽  
Vol 329 (2) ◽  
pp. 573-582 ◽  
Author(s):  
Nicholas Von Offenberg Sweeney ◽  
Philip M. Cummins ◽  
Eoin J. Cotter ◽  
Paul A. Fitzpatrick ◽  
Yvonne A. Birney ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Vascular Endothelial Cell ◽  
Cyclic Strain ◽  
Tube Formation ◽  
Endothelial Cell Migration ◽  
Vascular Endothelial

scholarly journals Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80268 ◽  
Author(s):  
Elham Zarrinpashneh ◽  
Tommaso Poggioli ◽  
Padmini Sarathchandra ◽  
Jonas Lexow ◽  
Laurent Monassier ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Tube Formation ◽  
Endothelial Cell Migration

scholarly journals VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

2012 ◽  
Vol 94 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Revu Ann Alexander ◽  
Gerald W. Prager ◽  
Judit Mihaly-Bison ◽  
Pavel Uhrin ◽  
Stefan Sunzenauer ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Urokinase Receptor ◽  
Endothelial Cell Migration

Mafba and  Mafbb Differentially Regulate Lymphatic Endothelial Cell Migration in Topographically Distinct Manners

2021 ◽  
Author(s):  
Hannah Arnold ◽  
Virginia Panara ◽  
Beata Filipek-Gorniok ◽  
Renae Skoczylas ◽  
Petter Ranefall ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Migration
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