scholarly journals TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function

2018 ◽  
Vol 122 (3) ◽  
pp. 479-488 ◽  
Author(s):  
Jay H. Traverse ◽  
Timothy D. Henry ◽  
Carl J. Pepine ◽  
James T. Willerson ◽  
Atul Chugh ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Left Ventricular Function ◽  
Time Trial ◽  
Left Ventricular ◽  
Cell Delivery ◽  
Regional Left Ventricular Function ◽  
Trial Effect ◽  
Stem Cell Delivery ◽  
St Elevation

scholarly journals One-Year Follow-up of Intracoronary Stem Cell Delivery on Left Ventricular Function Following ST-Elevation Myocardial Infarction

JAMA ◽  
2014 ◽  
Vol 311 (3) ◽  
pp. 301 ◽  
Author(s):  
Jay H. Traverse ◽  
Timothy D. Henry ◽  
Carl J. Pepine ◽  
James T. Willerson ◽  
Stephen G. Ellis
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
St Elevation ◽  
One Year

scholarly journals Circadian Dependence of Infarct Size and Left Ventricular Function After ST Elevation Myocardial Infarction

2012 ◽  
Vol 110 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Ronald Reiter ◽  
Cory Swingen ◽  
Luke Moore ◽  
Timothy D. Henry ◽  
Jay H. Traverse
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricular Function ◽  
Infarct Size ◽  
Ventricular Function ◽  
Left Ventricular ◽  
St Elevation Myocardial Infarction ◽  
St Elevation

Abstract 16538: Circulating Ketone Levels are Associated With Myocardial Infarct Size and Left Ventricular Function in Patients Presenting With St-Elevation Myocardial Infarction

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Marie Sophie L de Koning ◽  
B. D Westenbrink ◽  
Solmaz Assa ◽  
Dirk J van Veldhuisen ◽  
Robin P Dullaart ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ejection Fraction ◽  
Left Ventricular Function ◽  
Infarct Size ◽  
Ventricular Function ◽  
Myocardial Infarct ◽  
Left Ventricular ◽  
St Elevation Myocardial Infarction ◽  
Myocardial Infarct Size ◽  
St Elevation

Background: Circulating ketone bodies (KB) are increased in patients with heart failure, corresponding with increased utilization of KB as a cardiac fuel. Whether circulating KB are increased in patients presenting with ST-elevation myocardial infarction (STEMI) and whether this is associated with infarct size is unknown. Methods: KB were measured in 379 non-diabetic participants of the Glycometabolic Intervention as Adjunct to Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction (GIPS) III trial (Clinicaltrial.gov Identifier: NCT01217307). Non-fasting plasma concentrations of the KB beta-hydroxybutyrate, acetoacetate, acetone were measured at presentation, 24 hours and 4 months after STEMI presentation using nuclear magnetic resonance spectroscopy. Associations of circulating KB with myocardial infarct size and left ventricular ejection fraction (both detected with MRI at 4 months after STEMI) were determined using multivariable linear regression analyses. Results: Circulating KB were higher at baseline (total KB 520 [315-997](median [IQR], μmol/L), compared to 206 [174-246] at 24 hours and 166 [143-201] at 4 months ( P <0.001 for all)). KB at 24 hours were positively associated with enzymatic infarct size, HbA1C and beta-blocker use. KB at 24 hours were independently associated with MRI outcomes at 4 months. Higher KB was associated with larger myocardial infarct size (total KB: standardized β=0.17, 95%-confidence interval (CI) (0.04-0.31), P =0.012) and lower ejection fraction (standardized β=-0.15, 95%-CI (-0.29- -0.009), P =0.037). Conclusion: Circulating KB are increased in patients with STEMI and are independently associated with myocardial infarct size and left ventricular function after 4 months of follow-up. The increase in circulating KB may reflect maladaptive changes of myocardial metabolism during the acute phase.

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