Abstract 476: Pharmacogenetics and Drug Discovery for Anthracycline-Induced Cardiotoxicity Enabled by Sinoatrial Node-like Cells Derived From Human Pluripotent Stem Cells

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Shuibing Chen
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Pluripotent Stem Cells ◽  
Sinoatrial Node ◽  
Human Pluripotent Stem Cells

scholarly journals Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Sho Tanosaki ◽  
Shugo Tohyama ◽  
Yoshikazu Kishino ◽  
Jun Fujita ◽  
Keiichi Fukuda
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Pluripotent Stem Cells ◽  
Disease Modeling ◽  
Somatic Cells ◽  
Human Pluripotent Stem Cells ◽  
Regenerative Therapy ◽  
Differentiated Cells ◽  
Promising Application

AbstractPluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells.The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.

Multidisciplinary research of human pluripotent stem cells for application to cell therapy and drug discovery

2013 ◽  
Vol 10 (4) ◽  
pp. 160-163 ◽  
Author(s):  
Norio Nakatsuji ◽  
Eihachiro Kawase ◽  
Takamichi Miyazaki ◽  
Itsunari Minami ◽  
Kazuhiro Aiba
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Cell Therapy ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Multidisciplinary Research

Human pluripotent stem cells in drug discovery and predictive toxicology

2010 ◽  
Vol 38 (4) ◽  
pp. 1051-1057 ◽  
Author(s):  
Delphine Laustriat ◽  
Jacqueline Gide ◽  
Marc Peschanski
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Pluripotent Stem Cells ◽  
Genetic Diagnosis ◽  
Embryonic Stem ◽  
Human Pluripotent Stem Cells ◽  
The Body ◽  
Cell Phenotype ◽  
Predictive Toxicology ◽  
Stem Cell Lines

Human pluripotent stem cells are a biological resource most commonly considered for their potential in cell therapy or, as it is now called, ‘regenerative medicine’. However, in the near future, their most important application for human health may well be totally different, as they are more and more envisioned as opening new routes for pharmacological research. Pluripotent stem cells indeed possess the main attributes that make them theoretically fully equipped for the development of cell-based assays in the fields of drug discovery and predictive toxicology. These cells are characterized by: (i) an unlimited self-renewal capacity, which make them an inexhaustible source of cells; (ii) the potential to differentiate into any cell phenotype of the body at any stage of differentiation, with probably the notable exception, however, of the most mature forms of many lineages; and (iii) the ability to express genotypes of interest via the selection of donors, whether they be of embryonic origin, through pre-implantation genetic diagnosis, or adults, by genetic reprogramming of somatic cells, so-called iPSCs (induced pluripotent stem cells). In the present review, we provide diverse illustrations of the use of pluripotent stem cells in drug discovery and predictive toxicology, using either human embryonic stem cell lines or iPSC lines.

Human Pluripotent Stem Cells and Drug Discovery: A New Beginning

2016 ◽  
Vol 1 (1) ◽  
pp. 27
Author(s):  
Vinod Verma ◽  
A. Mehta ◽  
S.J.S. Flora
Keyword(s):  
Stem Cells ◽  
Drug Discovery ◽  
Pluripotent Stem Cells ◽  
Cost Effective ◽  
Cell Types ◽  
In Vitro Models ◽  
Human Pluripotent Stem Cells ◽  
Specific Cell ◽  
Attrition Rates

Human pluripotent stem cells (hPSCs) offer unique opportunities to discover and develop a new generation of drugs. Their ability to differentiate into virtually any cell type renders them a cost-effective, renewable source of tissue-specific cell types capable of predicting human responses towards novel chemical entities. Using these improved in vitro models based on physiologically relevant human cell types could result in identifying highly precise and safe compounds, thereby reducing drug attrition rates. Moreover, ability to develop humanised disease models for patient-stratified drug screening makes hPSCs an impeccable tool in translational medicine. In this mini-review we focus on the positives and negatives of utilising hPSC-derived cell types as drug discovery platforms with special emphasis on cardio-, hepato- and embryotoxicity.

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