Abstract 807: Rad Ablation as a Treatment to Target Cardiac Inotropy via L-type Calcium Channel Function

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Brooke Ahern ◽  
Bryana Levitan ◽  
Sudhakar Veeranki ◽  
Mihir Shah ◽  
Nemat Ali ◽  
...  
2000 ◽  
Vol 63 (5) ◽  
pp. 1262-1270 ◽  
Author(s):  
Patricia L. Collins ◽  
John J. Moore ◽  
David W. Lundgren ◽  
Elena Choobineh ◽  
Sharon M. Chang ◽  
...  

1996 ◽  
Vol 271 (3) ◽  
pp. C863-C868 ◽  
Author(s):  
A. D. Rosen

The effect of temperature on calcium channel function was studied in GH3 cells, using the whole cell patch-clamp methodology. Specific parameters examined were peak current amplitude, activation time, and inactivation time. Over the temperature range studied (22-37 degree C), the peak current amplitude was found to be a non-linear function of temperature, with low-threshold currents more temperature dependent than high-threshold currents. Both activation time and inactivation time were faster at higher temperatures, but, whereas inactivation was a continuous function of temperature, activation was not, with a distinct discontinuity between 27 and 32 degrees C. These findings suggest that caution must be exercised in extrapolating data on channel function obtained at room temperature to physiological temperatures.


2016 ◽  
Vol 57 (13) ◽  
pp. 5314 ◽  
Author(s):  
Bruce A. Berkowitz ◽  
Tiffany Schmidt ◽  
Robert H. Podolsky ◽  
Robin Roberts

2007 ◽  
Vol 580 (3) ◽  
pp. 745-754 ◽  
Author(s):  
Harold Couchoux ◽  
Bruno Allard ◽  
Claude Legrand ◽  
Vincent Jacquemond ◽  
Christine Berthier

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 21A-21A ◽  
Author(s):  
Thomas K Chin ◽  
Kendall S Graham ◽  
Chris Calendine ◽  
Y H He

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