scholarly journals Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke

Stroke ◽  
2018 ◽  
Vol 49 (4) ◽  
pp. 924-930 ◽  
Author(s):  
Longting Lin ◽  
Andrew Bivard ◽  
Timothy Kleinig ◽  
Neil J. Spratt ◽  
Christopher R. Levi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Acute Stroke ◽  
Ischemic Core

scholarly journals In patients with suspected acute stroke, CT perfusion-based cerebral blood flow maps cannot substitute for DWI in measuring the ischemic core

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0188891 ◽  
Author(s):  
William A. Copen ◽  
Albert J. Yoo ◽  
Natalia S. Rost ◽  
Lívia T. Morais ◽  
Pamela W. Schaefer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Acute Stroke ◽  
Ct Perfusion ◽  
Flow Maps ◽  
Ischemic Core

Simultaneous multimodal optical imaging of cerebral blood flow and oxygenation in focal ischemic core and penumbra in mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S488-S488
Author(s):  
Hwa Kyoung Shin ◽  
Phillip Jones ◽  
Andrew K Dunn ◽  
David A Boas ◽  
Michael A Moskowitz ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Optical Imaging ◽  
Ischemic Core

scholarly journals Cerebral Blood Flow and Blood Volume Measured by Magnetic Resonance Imaging Bolus Tracking After Acute Stroke in Pigs

Stroke ◽  
2000 ◽  
Vol 31 (8) ◽  
pp. 1958-1964 ◽  
Author(s):  
Masaharu Sakoh ◽  
Lisbeth Røhl ◽  
Carsten Gyldensted ◽  
Albert Gjedde ◽  
Leif Østergaard
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Acute Stroke ◽  
Blood Volume ◽  
Resonance Imaging ◽  
Bolus Tracking

scholarly journals Serial Changes in Cerebral Blood Flow and Flow—Metabolism Uncoupling in Primates with Acute Thromboembolic Stroke

2001 ◽  
Vol 21 (3) ◽  
pp. 202-210 ◽  
Author(s):  
Yuji Kuge ◽  
Chiaki Yokota ◽  
Masafumi Tagaya ◽  
Yasuhiro Hasegawa ◽  
Akira Nishimura ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Emission Tomography ◽  
Left Internal Carotid Artery ◽  
Left Middle Cerebral Artery ◽  
Thromboembolic Stroke ◽  
Primate Model ◽  
Positron Emission ◽  
Ischemic Core

The authors recently developed a primate thromboembolic stroke model. To characterize the primate model, the authors determined serial changes in cerebral blood flow (CBF) and the relation between CBF and cerebral metabolic rate of glucose (CMRglc) using high-resolution positron emission tomography. Thromboembolic stroke was produced in male cynomolgus monkeys (n = 4). Acute obstruction of the left middle cerebral artery was achieved by injecting an autologous blood clot into the left internal carotid artery. Cerebral blood flow was measured with [15O]H2O before and 1, 2, 4, 6, and 24 hours after embolization. CMRglc was measured with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) 24 hours after embolization. Lesion size and location 24 hours after embolization was determined by the 2,3,5-triphenyltetrazolium chloride (TTC) staining method. The results are summarized as follows: (1) 1 hour after embolization, CBF in the temporal cortex and the basal ganglia decreased to < 40% of the contralateral values. In these regions, regarded as an ischemic core, CBF decreased further with time and CMRglc at 24 hours also decreased. Infarcted lesions as indicated by being unstained with TTC were consistently observed in these regions. (2) In the parietal cortex and several regions surrounding the ischemic core, CBF was >40% of the contralateral values 1 hour after embolization and recovered gradually with time (ischemic penumbra). In these regions, CMRglc at 24 hours increased compared with that in the contralateral regions, indicating an uncoupling of CBF and CMRglc. No obvious TTC-unstained lesions were detected in these regions. The authors demonstrated a gradual recovery of reduced CBF, an elevated CMRglc and a CBF-CMRglc uncoupling in the penumbra regions of the primate model. Positron emission tomography investigations using this model will provide better understanding of the pathophysiology of thromboembolic stroke in humans.

scholarly journals Cerebral Blood Flow Thresholds in Acute Stroke Triage

Stroke ◽  
2006 ◽  
Vol 37 (9) ◽  
pp. 2202-2202 ◽  
Author(s):  
Michael H. Lev ◽  
R. Gilberto Gonzalez ◽  
Pam W. Schaefer ◽  
Walter J. Koroshetz ◽  
William P. Dillon ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Acute Stroke

CO2 reactivity and heterogeneity of cerebral blood flow in ischemic, border zone, and normal cortex

1989 ◽  
Vol 257 (2) ◽  
pp. H473-H482 ◽  
Author(s):  
S. C. Jones ◽  
B. Bose ◽  
A. J. Furlan ◽  
H. T. Friel ◽  
K. A. Easley ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Analysis ◽  
Border Zone ◽  
Core Area ◽  
Border Zones ◽  
Short Period ◽  
Thioflavine S ◽  
Ischemic Core ◽  
Normal Cortex

Regional arterial CO2 tension (PaCO2) reactivity of cerebral blood flow (CBF) and the effect of PaCO2 on the spatial and temporal heterogeneity of CBF were investigated by using autoradiographically determined CBF in the rat middle cerebral artery occlusion model after a 2-h period under pentobarbital anesthesia to clarify the relation between PaCO2 reactivity, CBF heterogeneity, and the temporal cycling of CBF. PaCO2 was adjusted to one of four levels. CBF was determined in four cortical areas and white matter using the tissue fractionation of [14C]iodoantipyrine [( 14C]IAP) in combination with vessel mapping using in vivo 4% thioflavine S. Specific PaCO2 reactivity and CBF were normal in the nonischemic cortex, normal, although slightly depressed, in the border zone far from the ischemic core area, and depressed in the border zone adjacent to the ischemic core area (P less than 0.001) and the ischemic core (P less than 0.001). In normocapnic and hypocapnic animals, CBF heterogeneity in the form of regularly spaced CBF columns perpendicular to the cortical surface was observed in the nonischemic hemisphere but was absent in the ischemic core area. In hypercapnic rats, flow columns were present in the ischemic core areas and border zones but were absent on the nonischemic side. There was a highly significant interaction (P less than 0.0001) in observer-determined heterogeneity grades between PaCO2 level and each of three areas, normal, border zone, and ischemic core. In normal cortex, comparison of the thioflavine S-stained vessels with the flow columns provided evidence supporting the concept of capillary recruitment and cycling as a mode of normal cerebral blood flow control. The presence of flow columns in severely ischemic areas in hypercapnic animals indicates that a short period of high PaCO2 transiently augments microregional flow and could enhance the delivery of a therapeutic agent to these microregions of the ischemic core. The regional analysis of PaCO2 reactivity suggests an index of future tissue viability.

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