[C G A T] Epita Matrix Genetics: Toward a Visualization of Genetic Codes via “Genetic Music”

Leonardo ◽  
2020 ◽  
Vol 53 (1) ◽  
pp. 88-89
Author(s):  
Renate C.-Z. Quehenberger ◽  
Ivan Stepanyan ◽  
Benjamin Skepper
Keyword(s):  
Hydrogen Bonds ◽  
Genetic Information ◽  
Musical Performance ◽  
Fundamental Level ◽  
Genetic Codes ◽  
Scientific Background ◽  
Visual Access ◽  
Technical Details ◽  
3D Representation ◽  
Genetic Structures

The authors describe the scientific background and technical details of the visualization of the mathematics underlying genetic codes applied to musical scales. “Genetic Music” provides audible access to genetic structures that become visible based on the fundamental level of nature as permutations of space itself. The carriers of genetic information characteristically possess hydrogen bonds in quantities 2 and 3 in complementary pairs of nitrogenous bases [GACT] in DNA and [GACU] in RNA. Since hydrogen is observed to expose the symmetries of the Penrose Patterns, visual access is achieved by means of a 3D representation of Penrose kites and darts named “epitahedron.” Those pyramid-shaped polyhedra represent the numbers of hydrogen bonds (C=G=3, A=T=2) that generate musical equivalence between the genetic alphabet and the 7 notes of the Pythagorean scale, as well as further and distinct correlations with “Fibonacci stage” “Genetic Music” scales. The visualization must be played synchronously with the musical performance.

scholarly journals Origin of hydrophobicity and enhanced water hydrogen bond strength near purely hydrophobic solutes

2016 ◽  
Vol 114 (2) ◽  
pp. 322-327 ◽  
Author(s):  
Joze Grdadolnik ◽  
Franci Merzel ◽  
Franc Avbelj
Keyword(s):  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Hydrophobic Hydration ◽  
Bulk Water ◽  
Water Molecules ◽  
Classical View ◽  
Fundamental Level ◽  
Hydrophobic Solute ◽  
Hydrophobic Solutes ◽  
Water Hydrogen

Hydrophobicity plays an important role in numerous physicochemical processes from the process of dissolution in water to protein folding, but its origin at the fundamental level is still unclear. The classical view of hydrophobic hydration is that, in the presence of a hydrophobic solute, water forms transient microscopic “icebergs” arising from strengthened water hydrogen bonding, but there is no experimental evidence for enhanced hydrogen bonding and/or icebergs in such solutions. Here, we have used the redshifts and line shapes of the isotopically decoupled IR oxygen–deuterium (O-D) stretching mode of HDO water near small purely hydrophobic solutes (methane, ethane, krypton, and xenon) to study hydrophobicity at the most fundamental level. We present unequivocal and model-free experimental proof for the presence of strengthened water hydrogen bonds near four hydrophobic solutes, matching those in ice and clathrates. The water molecules involved in the enhanced hydrogen bonds display extensive structural ordering resembling that in clathrates. The number of ice-like hydrogen bonds is 10–15 per methane molecule. Ab initio molecular dynamics simulations have confirmed that water molecules in the vicinity of methane form stronger, more numerous, and more tetrahedrally oriented hydrogen bonds than those in bulk water and that their mobility is restricted. We show the absence of intercalating water molecules that cause the electrostatic screening (shielding) of hydrogen bonds in bulk water as the critical element for the enhanced hydrogen bonding around a hydrophobic solute. Our results confirm the classical view of hydrophobic hydration.

An Analysis of Genetic Discrimination Legislation Proposed by the 105th Congress

1998 ◽  
Vol 24 (4) ◽  
pp. 443-480
Author(s):  
Jeremy A. Colby
Keyword(s):  
Human Genome ◽  
Charles Dickens ◽  
Genetic Disease ◽  
Human Genome Project ◽  
Genetic Information ◽  
Genetic Discrimination ◽  
Genome Project ◽  
Molecular Medicine ◽  
Genetic Codes ◽  
The Human Genome Project

It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness … it was the spring of hope, it was the winter of despair … we were all going direct to Heaven, we were all going direct the other way.—Charles DickensThe Human Genome Project (HGP) provides information about the human genome that will forever alter society and the way we view ourselves. The genetic age offers great potential, including a future where gene and germ-cell therapy may virtually eliminate genetic disease. However, genetic information may also result in a world characterized by genetic discrimination and genetic determinism. Although genetic information will be used to develop revolutionary treatments, such as gene therapy and other molecular medicine, it will also bring genetic discrimination and heretofore unrealized invasions into the privacy of our genetic codes.

New Rules Address Use of Genetic Information

2009 ◽  
Vol 42 (19) ◽  
pp. 11
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
Genetic Information

Use of molecular overlap to predict intermolecular repulsion in N... H-O hydrogen bonds

1998 ◽  
Vol 95 (3) ◽  
pp. 525-537 ◽  
Author(s):  
I. NOBELI S. L. PRICE R. J. WHEATLEY
Keyword(s):  
Hydrogen Bonds

Renal denervation - a clinical update and future directions

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 239-251
Author(s):  
Kai Mortensen ◽  
Klaas Franzen ◽  
Michael Reppel ◽  
Joachim Weil
Keyword(s):  
Renal Denervation ◽  
Future Directions ◽  
Scientific Background

The aim of this review is to give a contemporary update on renal denervation therapy focusing particularly on the scientific background and present literature as well as on different technical approaches and potential future directions.

On symmetrical O-H-O hydrogen bonds

1964 ◽  
Vol 25 (5) ◽  
pp. 487-492 ◽  
Author(s):  
R.E. Rundle
Keyword(s):  
Hydrogen Bonds
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