Marx's Philosophy and the Rule of Law in the Context of Establishing the Rule of Law in Bosnia and Herzegovina

The paper discusses the relationship between Marx's philosophy and the rule of law. The classical view of Marxism and the rule of law tells us that these are opposite notions. In this paper, the author presents different views in the context of the relationship between Marx's philosophy and the rule of law in relation to the classical Marxist view of the rule of law. Also, the author in this paper shows that Marx'sunderstanding of the rule of law does not necessarily contradict the modern concept of the rule of law, and also, Marx's understanding of the rule of law is related to the problem of building the rule of law in Bosnia and Herzegovina. The author conveys Marx's critique of 'law' as a critique of the process of building the rule of law in Bosnia and Herzegovina. In addition, the author shows that Marx's critique of 'law' is not necessarily an obstacle to the implementation of the modern concept of the rule of law.

Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles

Microtubule-targeting agents (MTAs) represent one of the most successful first-line therapies prescribed for cancer treatment. They interfere with microtubule (MT) dynamics by either stabilizing or destabilizing MTs, and in culture, they are believed to kill cells via apoptosis after eliciting mitotic arrest, among other mechanisms. This classical view of MTA therapies persisted for many years. However, the limited success of drugs specifically targeting mitotic proteins, and the slow growing rate of most human tumors forces a reevaluation of the mechanism of action of MTAs. Studies from the last decade suggest that the killing efficiency of MTAs arises from a combination of interphase and mitotic effects. Moreover, MTs have also been implicated in other therapeutically relevant activities, such as decreasing angiogenesis, blocking cell migration, reducing metastasis, and activating innate immunity to promote proinflammatory responses. Two key problems associated with MTA therapy are acquired drug resistance and systemic toxicity. Accordingly, novel and effective MTAs are being designed with an eye toward reducing toxicity without compromising efficacy or promoting resistance. Here, we will review the mechanism of action of MTAs, the signaling pathways they affect, their impact on cancer and other illnesses, and the promising new therapeutic applications of these classic drugs.

Classical View on Bhasma as Chief Formulation of Rasashastra: An Ayurveda Review

Minerals and metals based drugs possess important therapeutic potential and preparation of such medicines described in Rasashastra which deals with minerals and metals based formulations. The processing techniques related to the preparation of these medicines are very specific to make these drugs nontoxic and efficacious. Shodhana means purification and Marana means incineration/calcinations are main procedures associated with the preparation of Rasa- Aushdhis. Bhasmas are important preparation of this category which is considered as herbo-metallic preparation and description of Bhasma Kalpana is found in Ayurveda Samhitas during Arsha Sampradaya. These herbo-mineral/metallic formulations (Bhasma) mainly prepared by various steps of purification, grinding, mixing, heating, incineration and size reduction, etc. These drugs possess advantages of palatability, low dosing frequency, high potency, good bioavailability, optimum absorption and wide range of therapeutic spectrum. Bhasma not only used for therapeutic purpose but also advised for promoting general health and rejuvenating effects. Makshika bhasma, Swarna bhasma, Abhrak bhasma, Louha bhasma and Tamra bhasma, etc. are commonly used Bhasma preparation indicated for many pathological conditions including skin diseases, digestive ailments, sexual disorders, asthma and infections, etc.

From tip to toe – dressing centrioles in γTuRC

ABSTRACT Centrioles are microtubule-based cylindrical structures that assemble the centrosome and template the formation of cilia. The proximal part of centrioles is associated with the pericentriolar material, a protein scaffold from which microtubules are nucleated. This activity is mediated by the γ-tubulin ring complex (γTuRC) whose central role in centrosomal microtubule organization has been recognized for decades. However, accumulating evidence suggests that γTuRC activity at this organelle is neither restricted to the pericentriolar material nor limited to microtubule nucleation. Instead, γTuRC is found along the entire centriole cylinder, at subdistal appendages, and inside the centriole lumen, where its canonical function as a microtubule nucleator might be supplemented or replaced by a function in microtubule anchoring and centriole stabilization, respectively. In this Opinion, we discuss recent insights into the expanded repertoire of γTuRC activities at centrioles and how distinct subpopulations of γTuRC might act in concert to ensure centrosome and cilia biogenesis and function, ultimately supporting cell proliferation, differentiation and homeostasis. We propose that the classical view of centrosomal γTuRC as a pericentriolar material-associated microtubule nucleator needs to be revised.