Preparation of poly(ethylene glycol)-introduced cationized gelatin as a non-viral gene carrier

2005 ◽  
Vol 16 (11) ◽  
pp. 1447-1461 ◽  
Author(s):  
Toshihiro Kushibiki ◽  
Yasuhiko Tabata
Keyword(s):  
Ethylene Glycol ◽  
Gene Carrier ◽  
Viral Gene ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Lactose-Poly(ethylene Glycol)-Grafted Poly-l-Lysine as Hepatoma Cell-Targeted Gene Carrier

1998 ◽  
Vol 9 (6) ◽  
pp. 708-718 ◽  
Author(s):  
Young Hun Choi ◽  
Feng Liu ◽  
Jong Sang Park ◽  
Sung Wan Kim
Keyword(s):  
Ethylene Glycol ◽  
Hepatoma Cell ◽  
Gene Carrier ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier

2007 ◽  
Vol 342-343 ◽  
pp. 425-428 ◽  
Author(s):  
Dhananjay Jere ◽  
Tae Hee Kim ◽  
Rohidas B. Arote ◽  
Hu Lin Jiang ◽  
Myung Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Water Soluble ◽  
Gene Carrier ◽  
Gene Delivery System ◽  
Poly Ethylene Glycol ◽  
Wide Range ◽  
Poly Ethylene

Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.

Poly (amino ester) Composed of Poly (ethylene glycol) and Aminosilane Prepared by Combinatorial Chemistry as a Gene Carrier

2007 ◽  
Vol 25 (4) ◽  
pp. 875-885 ◽  
Author(s):  
Dhananjay Jere ◽  
Mi-Kyong Yoo ◽  
Rohidas Arote ◽  
Tae-Hee Kim ◽  
Myung-Haing Cho ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Combinatorial Chemistry ◽  
Gene Carrier ◽  
Amino Ester ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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