Elevated Levels of Lung Surfactant Protein A in Sera from Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Alveolar Proteinosis

1993 ◽  
Vol 147 (3) ◽  
pp. 723-729 ◽  
Author(s):  
Yoshio Kuroki ◽  
Shin Tsutahara ◽  
Noriharu Shijubo ◽  
Hiroki Takahashi ◽  
Masanori Shiratori ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Alveolar Proteinosis ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Alveolar Proteinosis ◽  
Lung Surfactant Protein

Aberrant Appearance of Lung Surfactant Protein A in Sera of Patients with Idiopathic Pulmonary Fibrosis and Its Clinical Significance

Respiration ◽  
1995 ◽  
Vol 62 (2) ◽  
pp. 64-69 ◽  
Author(s):  
Yasuhito Honda ◽  
Yoshio Kuroki ◽  
Noriharu Shijubo ◽  
Takuya Fujishima ◽  
Hiroki Takahashi ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Clinical Significance ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Lung Surfactant Protein

Surfactant protein A is degraded by alveolar macrophages

1996 ◽  
Vol 271 (2) ◽  
pp. L258-L266 ◽  
Author(s):  
S. R. Bates ◽  
A. B. Fisher
Keyword(s):  
Alveolar Macrophages ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Lung Lavage ◽  
Surfactant Protein A ◽  
Cell Association ◽  
Lag Period ◽  
Alveolar Proteinosis ◽  
Lung Surfactant Protein

The metabolism of iodinated lung surfactant protein A (SP-A) by alveolar macrophages in primary culture was examined to determine the role these cells play in the degradation of this surfactant protein. SP-A was isolated from lung lavage obtained from normal bovines, patients with alveolar proteinosis, and silica-treated rats. SP-A (0.5 microgram/ml) was incubated for 3 h with rat alveolar macrophages obtained by lung lavage. Cell association and degradation of human and rat SP-A was three times greater than that of bovine SP-A. During the 3-h period, 50% of total macrophage-associated SP-A was degraded. Degradation was time-, temperature-, and concentration-dependent after a 1-h lag period. SP-A degradation was intracellular, since NH4Cl inhibited degradation > 50%, and macrophage-conditioned medium was ineffective. Tenfold more SP-A was degraded by macrophages than by type II cells isolated after elastase digestion of rat lungs. There was little degradation of SP-A by HeLa cells. We conclude that alveolar macrophages take up and degrade SP-A and thus could contribute to the catabolism of SP-A in the lung.

scholarly journals Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 ◽  
Vol 168 (12) ◽  
pp. 5989-5992 ◽  
Author(s):  
Loïc Guillot ◽  
Viviane Balloy ◽  
Francis X. McCormack ◽  
Douglas T. Golenbock ◽  
Michel Chignard ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Immunostimulatory Activity ◽  
Toll Like Receptor 4 ◽  
Lung Surfactant Protein

Increased Surfactant Protein-A Levels in Patients With Newly Diagnosed Idiopathic Pulmonary Fibrosis

CHEST Journal ◽  
2004 ◽  
Vol 125 (2) ◽  
pp. 617-625 ◽  
Author(s):  
David S. Phelps ◽  
Todd M. Umstead ◽  
Mayra Mejia ◽  
Guillermo Carrillo ◽  
Annie Pardo ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Newly Diagnosed

Surfactant Protein-A Concentration in Bronchoalveolar Lavage Fluids of Patients With Pulmonary Alveolar Proteinosis

CHEST Journal ◽  
1993 ◽  
Vol 103 (2) ◽  
pp. 496-499 ◽  
Author(s):  
Yasuhito Honda ◽  
Hiroki Takahashi ◽  
Noriharu Shijubo ◽  
Yoshio Kuroki ◽  
Toyoaki Akino
Keyword(s):  
Bronchoalveolar Lavage ◽  
Pulmonary Alveolar Proteinosis ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Alveolar Proteinosis

Expression and Localization of Lung Surfactant Protein A in Human Tissues

2003 ◽  
Vol 29 (5) ◽  
pp. 591-597 ◽  
Author(s):  
Jens Madsen ◽  
Ida Tornøe ◽  
Ole Nielsen ◽  
Claus Koch ◽  
Wolfram Steinhilber ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Human Tissues ◽  
Lung Surfactant Protein

scholarly journals Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry ◽  
2016 ◽  
Vol 55 (26) ◽  
pp. 3692-3701 ◽  
Author(s):  
Boon Chong Goh ◽  
Huixing Wu ◽  
Michael J. Rynkiewicz ◽  
Klaus Schulten ◽  
Barbara A. Seaton ◽  
...  
Keyword(s):  
Binding Sites ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Lipid Binding ◽  
Surfactant Protein A ◽  
X Ray ◽  
X Ray Crystallography ◽  
Lung Surfactant Protein ◽  
Dynamics Simulations
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