Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis

2016 ◽  
Vol 193 (4) ◽  
pp. 362-375 ◽  
Author(s):  
Olivier Boucherat ◽  
Mathieu C. Morissette ◽  
Steeve Provencher ◽  
Sébastien Bonnet ◽  
François Maltais
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Development ◽  
Developmental Pathways ◽  
Chronic Obstructive ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease ◽  
Disease Relevance

scholarly journals Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3467
Author(s):  
Amel Nasri ◽  
Florent Foisset ◽  
Engi Ahmed ◽  
Zakaria Lahmar ◽  
Isabelle Vachier ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Development ◽  
Lung Diseases ◽  
Mesenchymal Cells ◽  
Chronic Obstructive ◽  
Multilineage Differentiation ◽  
Cell Type ◽  
Obstructive Pulmonary Disease ◽  
Lung Regeneration

Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.

Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis

2015 ◽  
Vol 1340 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Giuseppe Valacchi ◽  
Emanuela Maioli ◽  
Claudia Sticozzi ◽  
Franco Cervellati ◽  
Alessandra Pecorelli ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Scavenger Receptor ◽  
Chronic Obstructive ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease

scholarly journals Advances in Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 72 (1) ◽  
pp. 119-134
Author(s):  
Michael C. Ferrera ◽  
Wassim W. Labaki ◽  
MeiLan K. Han
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Respiratory Disorder ◽  
Significant Morbidity ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease ◽  
The Past ◽  
Disease Modifying Therapy ◽  
Disease Modifying

Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder with significant morbidity and mortality. Despite its prevalence, COPD is underdiagnosed, and many patients do not receive a diagnosis until the disease is clinically advanced. Recent basic science and clinical research have focused on the early physiologic and pathobiologic changes in COPD with the hopes of improving diagnosis, providing targets for disease-modifying therapy, and identifying patients most likely to benefit from early intervention. Available treatments for COPD have grown substantially in the past 20 years with the introduction of new oral and inhaled medications as well as novel surgical and bronchoscopic procedures. This article summarizes some of the recent advances in our understanding of disease pathogenesis and treatment paradigms.

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