scholarly journals Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis

2019 ◽  
Vol 202 (5) ◽  
pp. 1428-1440 ◽  
Author(s):  
Nayuta Saito ◽  
Jun Araya ◽  
Saburo Ito ◽  
Kazuya Tsubouchi ◽  
Shunsuke Minagawa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cellular Senescence ◽  
Chronic Obstructive ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease ◽  
Lamin B1

scholarly journals Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 7 ◽  
Author(s):  
Norihito Omote ◽  
Maor Sauler
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Pulmonary Disease ◽  
Cell Fate ◽  
Cellular Senescence ◽  
Cellular Stress ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Non Coding Rnas

Cellular senescence is a cell fate implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Cellular senescence occurs in response to cellular stressors such as oxidative stress, DNA damage, telomere shortening, and mitochondrial dysfunction. Whether these stresses induce cellular senescence or an alternative cell fate depends on the type and magnitude of cellular stress, but also on intrinsic factors regulating the cellular stress response. Non-coding RNAs, including both microRNAs and long non-coding RNAs, are key regulators of cellular stress responses and susceptibility to cellular senescence. In this review, we will discuss cellular mechanisms that contribute to senescence in IPF and COPD and highlight recent advances in our understanding of how these processes are influenced by non-coding RNAs. We will also discuss the potential therapeutic role for targeting non-coding RNAs to treat these chronic lung diseases.

Exploring the link between scavenger receptor B1 expression and chronic obstructive pulmonary disease pathogenesis

2015 ◽  
Vol 1340 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Giuseppe Valacchi ◽  
Emanuela Maioli ◽  
Claudia Sticozzi ◽  
Franco Cervellati ◽  
Alessandra Pecorelli ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Scavenger Receptor ◽  
Chronic Obstructive ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease

scholarly journals Advances in Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 72 (1) ◽  
pp. 119-134
Author(s):  
Michael C. Ferrera ◽  
Wassim W. Labaki ◽  
MeiLan K. Han
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Respiratory Disorder ◽  
Significant Morbidity ◽  
Disease Pathogenesis ◽  
Obstructive Pulmonary Disease ◽  
The Past ◽  
Disease Modifying Therapy ◽  
Disease Modifying

Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder with significant morbidity and mortality. Despite its prevalence, COPD is underdiagnosed, and many patients do not receive a diagnosis until the disease is clinically advanced. Recent basic science and clinical research have focused on the early physiologic and pathobiologic changes in COPD with the hopes of improving diagnosis, providing targets for disease-modifying therapy, and identifying patients most likely to benefit from early intervention. Available treatments for COPD have grown substantially in the past 20 years with the introduction of new oral and inhaled medications as well as novel surgical and bronchoscopic procedures. This article summarizes some of the recent advances in our understanding of disease pathogenesis and treatment paradigms.

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