Effect of Asbestos Exposure on Differentiation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Reaction of Human Peripheral Blood Mononuclear Cells

2013 ◽  
Vol 49 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Naoko Kumagai-Takei ◽  
Yasumitsu Nishimura ◽  
Megumi Maeda ◽  
Hiroaki Hayashi ◽  
Hidenori Matsuzaki ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mixed Lymphocyte Reaction ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Asbestos Exposure ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Defective lymphocyte glycosidases in the macrophage activation cascade of juvenile osteopetrosis

Blood ◽  
1996 ◽  
Vol 88 (4) ◽  
pp. 1473-1478 ◽  
Author(s):  
N Yamamoto ◽  
VR Naraparaju ◽  
PJ Orchard
Keyword(s):  
T Lymphocytes ◽  
B Lymphocytes ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Serum Vitamin ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Beta Galactosidase

Generation of macrophage-activating factor requires a precursor protein, Gc protein (serum vitamin D3-binding protein), as well as participation of beta-galactosidase of inflammation-primed B lymphocytes and sialidase of T lymphocytes. The treatment of human peripheral blood mononuclear cells with an inflammatory lysophospholipid induced beta-galactosidase and sialidase activity of lymphocytes, leading to the generation of macrophage-activating factor and activation of monocytes/macrophages. However, lysophospholipid treatment of peripheral blood mononuclear cells from three infantile patients with osteopetrosis resulted in no significant activation of monocytes/macrophages. The lysophospholipid-inducible beta- galactosidase activity of B lymphocytes as well as that of the sialidase of T lymphocytes was found to be defective in these patients.

Sign in / Sign up

Export Citation Format

Share Document