Preparation, Pharmacokinetics and Body Distribution of Silymarin-Loaded Solid Lipid Nanoparticles After Oral Administration

2007 ◽  
Vol 3 (2) ◽  
pp. 195-202 ◽  
Author(s):  
Jun He ◽  
Shixiang Hou ◽  
Weigen Lu ◽  
Lin Zhu ◽  
Jianfang Feng
Keyword(s):  
Oral Administration ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Body Distribution

Encapsulating Rifampicin into SLNs: A Viable Option for Managing its Bioavailability Issues Upon Co-Delivery with Isoniazid

2020 ◽  
Vol 17 (4) ◽  
pp. 343-347
Author(s):  
Harinder Singh ◽  
Ruchi Sood ◽  
Tridib Chaira ◽  
Alka Khanna ◽  
Dilip J Upadhaya ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Oral Administration ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Fixed Dose ◽  
Acidic Ph ◽  
Viable Option ◽  
Time Points ◽  
Solid Lipid

Background: Rifampicin is known to degrade at the acidic pH of the stomach, especially in the presence of isoniazid. Although isoniazid also degrades partially, its degradation is reversible. Objective: Presently, we provide a proof of the fact that the simultaneous oral administration of rifampicin (RIF), upon incorporation into solid lipid nanoparticles (RIF-SLNs), with isoniazid (INH) overcomes its INH-induced degradation and improves its oral bioavailability in rats. Methods: Solid lipid nanoparticles of RIF (RIF-SLNs) were prepared using a novel and patented method. The effect of INH was investigated on in vivo bioavailability of RIF both in its free and encapsulated (RIF-SLNs) form, after oral administration to rats. Results: Cmax and AUC0-∞ of RIF increased 158 % and 125 %, respectively, upon incorporation into SLNs versus free RIF when combined with INH. The Tmax decreased from 5.67 h to 3.3 h, and the plasma concentration of RIF remained above its MIC (8 μg/ml) at all the tested time points starting with 15 min, when administered as RIF-SLNs in combination with INH. Conclusions: The results confirm the scope of combining RIF-SLNs with INH to overcome the bioavailability of free RIF when combined with INH, especially in fixed dose combinations.

scholarly journals Solid lipid nanoparticles modified with stearic acid–octaarginine for oral administration of insulin

2012 ◽  
pp. 3333 ◽  
Author(s):  
Huixia Lv Hui-Xia ◽  
Zhen-Hai Zhang ◽  
Yin-long Zhang ◽  
Xu Wang ◽  
Xi-Ru Xu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Stearic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Characterization and Body Distribution ofβ-Elemene Solid Lipid Nanoparticles (SLN)

2005 ◽  
Vol 31 (8) ◽  
pp. 769-778 ◽  
Author(s):  
Yanzhi Wang ◽  
Yihui Deng ◽  
Shirui Mao ◽  
Shengxuan Jin ◽  
Jian Wang ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Body Distribution

scholarly journals Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

2021 ◽  
Vol 24 ◽  
pp. 509-532
Author(s):  
Nestor Mendoza-Muñoz ◽  
Zaida Urbán-Morlán ◽  
Gerardo Leyva-Gómez ◽  
María de la Luz Zambrano-Zaragoza ◽  
Elizabeth ¨Piñón-Segundo ◽  
...  
Keyword(s):  
Oral Administration ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Neurological Diseases ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Beneficial Effects ◽  
Solid Lipid ◽  
First Choice ◽  
Poorly Soluble

Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects.

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