scholarly journals Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery

2021 ◽  
Vol 24 ◽  
pp. 509-532
Author(s):  
Nestor Mendoza-Muñoz ◽  
Zaida Urbán-Morlán ◽  
Gerardo Leyva-Gómez ◽  
María de la Luz Zambrano-Zaragoza ◽  
Elizabeth ¨Piñón-Segundo ◽  
...  
Keyword(s):  
Oral Administration ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Neurological Diseases ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Beneficial Effects ◽  
Solid Lipid ◽  
First Choice ◽  
Poorly Soluble

Nanoparticles have shown overall beneficial effects in drug administration. Specifically, solid lipid nanoparticles (SLN) have emerged as an alternative to polymer-based systems. However, the oral administration of SLN, the first choice for conventional medications, has not been addressed due to the taboo surrounding the complicated transit that this delivery route entails. This review focuses on the encapsulation of drugs into SLN as a strategy for improving oral administration. Examples of applications of SLN to enhance the absorption and bioavailability of poorly-soluble drugs and protect acid-labile active molecules are discussed. This work also emphasizes the importance of developing SLN-based systems to treat health issues such as neurological diseases and cancer, and combat antibiotic resistance, three significant and increasingly common current public health problems. The review sections clarify how SLN can improve bioavailability, target therapeutic agents, and reduce side effects.

Solid lipid nanoparticles for oral drug delivery

2020 ◽  
Author(s):  
S. Khaleel Basha ◽  
R. Dhandayuthabani ◽  
M. Syed Muzammil ◽  
V. Sugantha Kumari
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Solid Lipid

scholarly journals Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5432
Author(s):  
Haniza Hassan ◽  
Siti Khadijah Adam ◽  
Ekram Alias ◽  
Meor Mohd Redzuan Meor Mohd Affandi ◽  
Ahmad Fuad Shamsuddin ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Drug Delivery ◽  
Entrapment Efficiency ◽  
Fold Increase ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Solid Lipid ◽  
Central Composite

Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute kidney injury. For this reason, a suitable delivery system for acyclovir was developed to improve the pharmacokinetic limitations and ultimately administer the drug at a lower dose and/or less frequently. In this study, solid lipid nanoparticles were designed to improve the oral bioavailability of acyclovir. The central composite design was applied to investigate the influence of the materials on the physicochemical properties of the solid lipid nanoparticles, and the optimized formulation was further characterized. Solid lipid nanoparticles formulated from Compritol 888 ATO resulted in a particle size of 108.67 ± 1.03 nm with an entrapment efficiency of 91.05 ± 0.75%. The analyses showed that the optimum combination of surfactant and solid lipid produced solid lipid nanoparticles of good quality with controlled release property and was stable at refrigerated and room temperature for at least 3 months. A five-fold increase in oral bioavailability of acyclovir-loaded solid lipid nanoparticles was observed in rats compared to commercial acyclovir suspension. This study has presented promising results that solid lipid nanoparticles could potentially be used as an oral drug delivery vehicle for acyclovir due to their excellent properties.

scholarly journals A concise review on preparation methods used for the development of solid lipid nanoparticles

2021 ◽  
Vol 11 (1-s) ◽  
pp. 162-169
Author(s):  
Vasu Deva Reddy Matta
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Water Soluble ◽  
Oral Drug ◽  
Preparation Methods ◽  
Hydrophilic Drugs ◽  
Solid Lipid

Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery. Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.

scholarly journals Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles

2018 ◽  
Vol 15 (139) ◽  
pp. 20170932 ◽  
Author(s):  
Luíse L. Chaves ◽  
Sofia Lima ◽  
Alexandre C. C. Vieira ◽  
Domingos Ferreira ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Water Solubility ◽  
Oral Drug Delivery ◽  
Drug Loading ◽  
Amorphous State ◽  
Lipid Nanoparticles ◽  
Oral Drug ◽  
Solid Lipid ◽  
Cytotoxicity Studies

The aim of this work was to develop solid lipid nanoparticles (SLNs) loaded with clofazimine (CLZ) (SLNs-CLZ) to overcome its intrinsic toxicity and low water solubility, for oral drug delivery. A Box–Behnken design was constructed to unravel the relations between the independent variables in the selected responses. The optimized SLNs-CLZ exhibited the following properties: particle size ca 230 nm, zeta potential of −34.28 mV, association efficiency of 72% and drug loading of 2.4%, which are suitable for oral delivery. Further characterization included Fourier transformed infrared spectroscopy that confirmed the presence of the drug and the absence of chemical interactions. By differential scanning calorimetry was verified the amorphous state of CLZ. The storage stability studies ensured the stability of the systems over a period of 12 weeks at 4°C. In vitro cytotoxicity studies evidenced no effect of both drug-loaded and unloaded SLNs on MKN-28 gastric cells and on intestinal cells, namely Caco-2 and HT29-MTX cells up to 25 µg ml −1 in CLZ. Free CLZ solutions exhibited IC 50 values of 16 and 20 µg ml −1 for Caco-2 and HT29-MTX cells, respectively. It can be concluded that the optimized system, designed considering important variables for the formulation of poorly soluble drugs, represents a promising platform for oral CLZ delivery.

Solid Lipid Nanoparticles for Oral Drug Delivery: A Review

2020 ◽  
Vol 10 (3) ◽  
pp. 208-224
Author(s):  
Manish Gautam ◽  
Madhu Verma ◽  
Iti Chauhan ◽  
Mohd. Yasir ◽  
Alok Pratap Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Oral Drug Delivery ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Water Soluble ◽  
Oral Drug ◽  
Pharmacokinetic Studies ◽  
Future Prospects ◽  
Solid Lipid

Background: The high molecular weight and increasing lipophilicity of drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, nano-sized formulations are in trend recently. The use of Solid lipid nanoparticles (SLNs) offers new insight into the formulation of the poor soluble and low bioavailable drug. Objective: The study aimed to investigate the literature concerning the development of SLNs for oral drug delivery of poorly soluble drugs, with a view survey the various methods of manufacturing and evaluation of formulation of SLNs and future prospects of SLNs and application of SLNs in oral delivery systems. Conclusion: Oral drug delivery is looking ahead progressively into newer directions due to the realization of various poor performance limiting factors such as reduced drug solubility or absorption, rapid metabolism, high actuation in plasma level of drug and variability caused due to food effect. These play a vital role in disappointing in vivo results, which leads in the failure of the conventional delivery system. Since the last decade, oral drug delivery has taken a new dimension with the increasing application of SLNs as a carrier for the delivery of poorly water-soluble or lipophilic drugs. The site-specific and sustained release effect of the drug is better achieved by using SLNs. This review highlights the various pros and cons, manufacturing techniques, characterization, and future prospects of SLNs in oral drug delivery systems.

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